i'm 44 and, to put it mildly, have felt miserable for the last year or so - no energy, fatigue, constant aches and pains, insomnia, night sweats, brain fog, fibroids, hair falling out, weight gain etc etc...i also went back to a super stressful job in sept after not working for six years. my ob/gyn has recommended hysterectomy for fibroids so i am researching options for that but really need to resolve all the other symptoms as well. i recently found an alternative doc who doesnt take insurance but who was willing to do something other than say i was just going through normal aging process. i had blood tests done with following results: estradiol 500 pg/mL, progesterone .8 ng/mL, vit D 9.4. doc has started me on 4% progesterone cream 20mg/ day, vit D 10,000 iu/day. after reading through older posts i'm thinking i need waaay more progesterone. if i did the conversions correctly my ratio of estrogen to progesterone is 1:1.6 and you believe a ratio of 1:600 is needed to feel well. how much should i be supplementing daily to bring my levels into balance? also concerned whether it matters what day my tests were done? i am peri-meno with erratic cycles. my last period started 5/2/12 but before that started 9/18/11, blood tests were run on 4/6/12. does timing matter in my case? do you think it ok to supplement with natpro (in addition to above - i tried to order but you are currently out of stock:-(). i'm a little worried about the initial estro flare as have just spent a fortune on laser hair removal on face and dermatologist and am finally pleased with the way my skin looks... anxiously awaiting your feedback. thanks for this site.