Progesterone Blog

Feb 21, 2026

Endocrine Disruptors

Environmental toxins have increased dramatically since the Second World War, and with them, the rise in hormone-related and degenerative diseases. Although all vertebrates are affected, these conditions are most prevalent in Western cultures, where industrialisation has spread synthetic chemicals into every corner of daily life. Many of these substances mimic the hormone oestrogen and are now known as endocrine disruptors. Pesticides, dioxins and PCBs are among the most concerning, with over a hundred hormone-disrupting chemicals identified — many persisting in the environment for decades or even centuries.

As exposure to oestrogenic toxins has increased, so too has the incidence of hormone-driven diseases. Breast cancer, prostate disorders, infertility and reproductive abnormalities have all risen sharply over the past half century. Sperm counts have declined significantly, and reproductive abnormalities in both men and animals are increasingly linked to prenatal exposure to hormone-mimicking chemicals. Evidence also suggests links between environmental toxins and conditions such as endometriosis, miscarriage and immune dysfunction.

A key concern is the imbalance between oestrogen and progesterone. Oestrogen is an excitatory, inflammatory hormone, while progesterone acts as its natural counterbalance. When environmental toxins increase the oestrogenic burden, particularly in the absence of adequate progesterone, tissues become more vulnerable to disease. Research has associated unopposed oestrogen with cancers of hormone-sensitive tissues and reproductive disorders, while progesterone appears protective through its anti-inflammatory and regulatory actions.

Modern lifestyles have also extended lifetime oestrogen exposure. Earlier puberty, fewer pregnancies and longer lifespans mean women now experience far more menstrual cycles than in the past, further compounding the toxic load. At the same time, persistent environmental chemicals remain widespread in air, soil, water, food, household and personal care products and fabrics, ensuring ongoing exposure across generations.

Ultimately, progesterone plays a fundamental role in protecting the body against environmental stressors. Far from being merely a reproductive hormone, it is essential for both men and women, acting as an anti-inflammatory, antioxidant and neuroprotective agent. Understanding the relationship between environmental toxins and hormonal balance is therefore central to protecting long-term health in the modern world.

To find out more please visit our dedicated page on Environmental Toxins, and read the research papers presented there.

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Feb 20, 2026

Progestrone for PPD

Hi, I would like to get some guidance and help from any fellow friends who have used progesterone in postpartum to prevent PPD and help balance hormones.

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Feb 14, 2026

Breast Cysts

Breast cysts — often called fibrocystic breasts, mammary dysplasia or chronic cystic mastitis — are extremely common, affecting the majority of women at some point in their lives. They typically present as tender, movable lumps in the breast tissue, often accompanied by swelling, pain or nipple discharge. Although benign, they can cause significant discomfort and anxiety. They tend to occur most often between the ages of 30 and 50, and are rare after menopause unless HRT is being used. 

One feature of fibrocystic breasts is their link with the menstrual cycle. Many women notice symptoms worsening just before menstruation, when progesterone levels naturally fall. Normally these cysts resolve once bleeding begins. When they persist, it is often a sign that progesterone levels remain too low throughout the cycle. From the mid-thirties onward, anovulatory cycles become more common, leading to declining progesterone production — a key factor in the development of breast cysts.

Three hormones play central roles: oestrogen, prolactin and progesterone. Oestrogen and prolactin are inflammatory and stimulate proliferation in breast tissue, whereas progesterone acts as a natural anti-inflammatory. It inhibits oestrogen-driven cell growth, promotes cellular differentiation and suppresses prolactin. When progesterone is insufficient, this balance is lost, allowing swelling, tenderness and cyst formation to develop.

Elevated prolactin can further suppress ovulation, creating a cycle of worsening progesterone deficiency. Stress contributes to this by lowering dopamine, the neurotransmitter that normally restrains prolactin production. Nutritional factors also matter: inadequate protein intake may impair dopamine synthesis, while iodine deficiency can contribute to breast tenderness and cystic changes.

From a natural perspective, restoring hormonal balance is key. Progesterone supplementation — often applied as a cream directly to the breasts — is frequently beneficial, with dosage adjusted according to symptoms. Supporting dopamine levels through adequate protein or tyrosine intake may help regulate prolactin, while nutrients such as iodine, DIM and calcium-D-glucarate may assist oestrogen metabolism.

Conventional management typically focuses on clinical exams, mammograms or ultrasound imaging to confirm cysts, with aspiration or surgery reserved for persistent or large lesions. A less invasive method that may be employed is Thermography.

While these approaches address symptoms, correcting the underlying hormonal imbalance offers a more fundamental path to lasting relief.

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Feb 10, 2026

Causes of Memory Loss

Memory is the brain’s ability to store and recall information. When this system fails, we experience memory loss, which ranges from mild forgetfulness to severe cognitive impairment such as dementia or Alzheimer’s disease. Dementia is defined as a decline in memory and thinking that interferes with daily life. Alzheimer’s is the most common form, accounting for roughly 60–80 % of cases in elderly populations. True memory disorders are not normal aging; they arise when specific biological or environmental factors damage brain structure or function.

A wide array of causes have been implicated in memory impairment. Central to many is oxidative stress, a condition where reactive free radicals overwhelm the brain’s limited antioxidant defenses, damaging neurons and synaptic communication. Chronic stress also plays a role by increasing inflammatory cytokines that disrupt brain function. Epigenetic changes — alterations in gene expression triggered by early-life stress, toxin exposure, or nutrient deficiencies — can predispose individuals to cognitive decline later in life.

Several metabolic and lifestyle factors contribute: persistent high blood sugar and diabetes accelerate the formation of advanced glycation end products (AGEs) that foster inflammation and neuronal damage. Poor blood flow, vascular injury, and multiple small strokes (multi-infarct dementia) directly injure the brain. Nutrient deficiencies—especially vitamin B12 and folate—are linked to more rapid cognitive decline, while excessive alcohol, lack of exercise, and thyroid dysfunction further undermine memory performance. Drug side effects, particularly from anticholinergic medications that block acetylcholine (a neurotransmitter essential to memory), also impair cognition. Statins have been associated with increased risk of memory problems as well.

Hormonal balance emerges as a critical factor. Excess catabolic hormones like cortisol, oestrogen, and thyroid hormones relative to anabolic hormones including progesterone, testosterone, DHEAS, and IGF-1 may promote oxidative stress and reduce neuroprotection. Progesterone, in particular, is noted for its neuroprotective actions: it reduces excitotoxicity (cell death from excess glutamate and calcium), increases brain-derived neurotrophic factor (BDNF), supports myelin integrity, and attenuates tau pathology common in Alzheimer’s.

Environmental toxins — aluminum being highlighted — may trigger pathological protein changes seen in Alzheimer’s. Immune conditions like lupus and fibromyalgia can manifest as “brain fog,” and depression—often linked to lower BDNF—is commonly found alongside cognitive impairment.

Finally, while several modern drugs (e.g., cholinesterase inhibitors) modestly slow symptom progression by preserving acetylcholine, they do not halt the underlying damage. A holistic understanding of memory loss therefore integrates oxidative stress, metabolic health, hormones, lifestyle, nutrients, and environmental exposures.

For more information read our page Causes of memory loss

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Feb 03, 2026

Migraines & Hormone Balance

Migraines aren’t just intense headaches — they’re a systemic neurological crisis that disrupts your senses, drains your energy, and derails your life. What most people don’t realize is that women are affected three to four times more often than men, and understanding why reveals far deeper insights into migraine biology and prevention.

At the heart of this disparity are hormonal dynamics. Before puberty, boys and girls experience migraines at nearly the same rate, but once estrogen surges begin in adolescence, the gender gap quickly widens. Estrogen both primes the brain’s pain pathways and triggers attacks: high levels make the nervous system hypersensitive, while sudden drops — such as those that occur before menstruation or after childbirth — spark electrical instability in the brain that initiates migraine pain. Natural progesterone, in contrast, has a calming effect, helping counteract estrogen’s tendency to heighten inflammation and nerve excitability.

These hormonal swings explain why migraines cluster around key female life stages — puberty, menstruation, pregnancy, perimenopause, and menopause — and why many women see their migraine patterns shift as hormone levels change. For example, some women experience relief if hormone levels stabilize during pregnancy or after menopause.

Underlying these surface triggers, however, is a deeper issue: mitochondrial dysfunction. Migraines are energy-driven events. The brain demands vast amounts of ATP (cellular energy), and when mitochondria — the “powerhouses” of cells — are compromised, the brain becomes much more susceptible to stressors, hormonal fluctuation, and inflammation. One of the biggest disruptors of mitochondrial health is excess linoleic acid (LA) from seed oils and highly processed foods. Oxidized LA damages mitochondrial membranes and proteins, reducing ATP production and increasing oxidative stress — a perfect storm for migraine susceptibility.

This biological vulnerability is compounded by genetic, structural, and stress-related factors. Women are more likely to experience longer, more intense attacks, and to report greater disability from migraines than men. Social and environmental stressors — such as shift work, poor sleep, and workplace triggers like bright lights or chemical odors — further elevate risk.

The good news is that migraines aren’t inevitable. By stabilizing hormones, protecting mitochondria, and reducing inflammation, you can significantly cut frequency and intensity. Practical steps include lowering linoleic acid intake, supporting melatonin through proper light exposure and sleep hygiene, and ensuring adequate nutrients like magnesium, CoQ10, and B vitamins for brain energy. Tracking personal triggers and supporting natural progesterone balance can also help women align their biology with lasting migraine relief.

Read this excellent article by Dr. Mercola, Why Is Migraine More Common in Women Than Men?, and visit our pages on Inflammation and Migraine Treatment.

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Jan 30, 2026

Progesterone: A Central Hormone in Calming Psoriasis Inflammation

Psoriasis is commonly seen as a skin problem — red, scaly patches that itch and flare without warning — but research shows the real driver may be hormonal imbalance deep inside the body, especially low progesterone. Progesterone isn’t just a reproductive hormone; it plays a crucial role in regulating the immune system and calming inflammation, two key factors in psoriasis development.

The Hormonal Signature of Psoriasis:

Large clinical data show that women with psoriasis consistently have lower progesterone levels than those without the condition. In one major study, progesterone in women with psoriasis averaged about 7.59 ng/mL, significantly lower than 9.4 ng/mL in women without psoriasis. This difference may seem modest in lab terms, but biologically it reflects a meaningful loss of progesterone’s anti-inflammatory influence.

Progesterone acts like a natural brake on immune activation, dampening inflammatory white blood cells and preventing overreaction to everyday stressors. When progesterone drops, this brake weakens, allowing immune signals that drive psoriasis — such as rapid skin cell turnover, redness and itch — to become stronger and more persistent.

Progesterone vs. Estrogen: Balance Matters More Than Levels:

Inflammation in psoriasis isn’t just about low progesterone — it’s about the ratio of progesterone to estrogen. Even when estrogen levels look normal in blood tests, tissues can still “feel” estrogen more strongly if progesterone is low. This shift creates what researchers and clinicians call estrogen dominance, where estrogen’s pro-inflammatory effect goes unchecked because progesterone is no longer there to balance it.

This imbalance helps explain why many women notice psoriasis flares at specific times: in the luteal phase before menstruation, after childbirth, and during menopause — all periods when progesterone naturally falls relative to estrogen. The key takeaway is that healthy progesterone levels act like an internal buffer against this inflammatory shift.

Progesterone and Immune-Driven Symptoms:

Low progesterone also links to systemic immune activity, not just visible skin symptoms. Without enough progesterone, the immune system becomes more reactive to stress, lifestyle triggers and environmental exposures, increasing the likelihood and severity of psoriasis flare-ups. Supporting progesterone isn’t just about hormone numbers — it’s about strengthening immune tolerance so that everyday stresses don’t erupt as skin inflammation.

For more information see our pages on Progesterone and psoriasis and, Inflammatory diseases

And read this article by Dr Mercola Low Progesterone and DHEA Drive Psoriasis

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Jan 29, 2026

Miss

Hi everyone. I just needed some thoughts or ideas so I decided to post here. First of all this website has so much information and I am grateful for

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Jan 26, 2026

Low libido

Low libido—whether described as poor sexual desire, low arousal, or hypoactive sexual desire disorder—is a common and complex issue affecting both men and women, shaped by physical, endocrinologic, neurological and psychogenic factors. Libido is not simply wanting sex; it is the subjective energy of the sexual drive, and its disruption is widespread across ages and circumstances.

Sexual dysfunction is influenced by mood, relationships, medications, and systemic health. Physical contributors include low dopamine, low progesterone, low vitamin D, low testosterone, low zinc, atherosclerosis, hypothyroidism, diabetes, cardiovascular disease and many commonly prescribed drugs. Psychological causes range from depression and anxiety to past trauma and stress.

Contrary to common belief, testosterone alone does not reliably dictate libido. While often prescribed, testosterone therapy—especially in women—carries many side effects, and evidence shows plasma testosterone levels correlate poorly with sexual desire. Progesterone, historically underestimated, appears to play a much greater role in sexual behavior and response than typically acknowledged.

Scientific findings challenge the simplistic view that only androgens drive desire. Progesterone is produced not just by the ovaries or testes but also by the brain and adrenal glands, and animal research shows progesterone surges are linked with sexual activity, facilitate behaviour even in the absence of other steroids, and support erection mechanisms. Progesterone receptors also mediate dopamine’s action—a key neurotransmitter for motivation, arousal and ejaculation.

Normal sexual response also depends on nitric oxide (NO), hydrogen sulfide and other vasodilators that enable blood flow to sexual tissues. Progesterone and vitamin D enhance vasodilation and NO production, while adequate dopamine keeps prolactin in check (since high prolactin suppresses libido). Nutrients such as tyrosine, arginine, NAC, magnesium and vitamin K all support these pathways.

Life stages like post-partum and peri-menopause often coincide with low libido, paralleling drops in progesterone even when estrogen and testosterone remain unchanged.

Natural treatment emphasizes restoring progesterone alongside critical nutrients: vitamin D to support dopamine synthesis and testosterone levels; tyrosine to prevent prolactin elevations; arginine and NAC for vascular function; and cofactors like magnesium and vitamin K to maintain arterial health. Consider also herbs with aphrodisiac properties and hormone testing, especially for progesterone, vitamin D and prolactin.

For more information visit our webpage on Low Libido

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Jan 24, 2026

Natpro tube - SA

natpro tube south africa

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Jan 21, 2026

Miscarriage: Understanding Early Pregnancy Loss

Have you experienced the heartbreak of early pregnancy loss, or wondered why conception isn’t as simple as you hoped? If so, you are not alone. Miscarriage is far more common than many realize—affecting up to 1 in 4 recognized pregnancies. Yet, the silence and confusion around this topic can leave you feeling isolated and searching for answers.

Why Does Miscarriage Happen?

Early miscarriage—especially in the first trimester—often feels like a mystery. While chromosomal issues are a frequent cause, another key factor is often overlooked: hormone balance. In particular, progesterone plays a vital role in preparing and maintaining the uterine lining so that a fertilized egg can implant and thrive.

When progesterone levels are too low, the body may not sustain the pregnancy, leading to what’s sometimes called "luteal phase defect". A deficiency in Vitamin D is also a major contributing factor, a lack of vitamin D3 reduces the benefits of progesterone.

A few symptoms that may suggest a progesterone deficiency may include:

•Spotting or light bleeding before your period

•Water retention

•Unexplained fatigue or mood swings and mild depression

•Difficulty conceiving despite regular cycles

Progesterone’s Protective Role in Conception & Pregnancy:

After ovulation, your body produces more progesterone to thicken the uterine lining and create a nourishing environment for a developing embryo. If levels fall too soon, the lining may shed—resulting in a period or an early loss, even before you realize you’re pregnant.

For those who have experienced more than one miscarriage, or have symptoms of progesterone deficiency, supplementing with a bio-identical progesterone cream may offer support. Many women in our community have found hope and success by addressing this often-missed factor.

What Can You Do? Steps Toward Hormonal Harmony:

•Track your cycle: Note the length, ovulation, and any spotting. Irregularities can signal hormone imbalances.

•Take our free Progesterone Deficiency Questionnaire: This simple tool helps you identify symptoms and risk factors.

•Read our dedicated pages on miscarriage, FAQ conception, infertility and hormone balance to find answers to questions about fertility, implantation, and hormone support.

Consider natural progesterone support, using a cream like Natpro Progesterone Cream may help restore balance and support your pregnancy. (You are encouraged to consult with a health care practitioner and, in reference to any information shared here or on our websites, preferably one with specific knowledge of progesterone therapy.)

Connect with others: Our community forums are a supportive space to share your story or seek advice from those who truly understand.

You Are Not Alone

Experiencing miscarriage or fertility struggles can be deeply isolating, but there is hope. Many women have found answers and renewed optimism by understanding the role of hormones—especially progesterone—in early pregnancy. If you or someone you know is searching for clarity, know that compassionate support and actionable solutions are available.

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Jan 03, 2026

Cortisol

I'm not clear on what progesterone does to cortisol levels. Not sure if it's helping mine. I have continuous high cortisol at night and mornings. Yet

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Dec 30, 2025

🌱 Fertility, Infertility & Progesterone

If you are feeling confused or overwhelmed by fertility challenges, or wondering if hormone balance might be affecting your ability to conceive you are not alone—many women and couples face uncertainty, frustration, and a lack of clear answers when it comes to fertility and infertility.

Understanding Fertility & the Hidden Role of Progesterone:

Fertility is a complex dance of hormones, timing, and health. While most people focus on ovulation and sperm health, one of the most overlooked factors is progesterone—a hormone essential for preparing the uterus for implantation and supporting early pregnancy. Without enough progesterone, even a healthy egg and sperm may not result in a successful pregnancy.

Some of the signs of infertility linked to hormone imbalance include:

•Irregular or absent periods•Short luteal phase (the time between ovulation and your next period)•Spotting before your period starts•Recurrent miscarriages•Unexplained fatigue, anxiety, or mood swings•Symptoms of estrogen dominance (bloating, breast tenderness, PMS)

Many women are told that infertility is “unexplained” or simply due to age, but the truth is that progesterone deficiency is a common—and often correctable—cause.

Progesterone Deficiency: Why It Matters for Conception:

Progesterone is produced after ovulation and is vital for thickening the uterine lining and maintaining it so an embryo can implant and grow. If levels are too low, implantation may not occur, or early miscarriage can result. This is sometimes called “luteal phase defect.”

Factors that can lower progesterone include:•chronic stress•excessive exercise•poor diet•age•underlying health conditions like PCOS or thyroid issues.•Environmental toxins and xenoestrogens (chemicals that mimic estrogen).

Common questions about conception include:

"Can I get pregnant if I have irregular cycles?"

"Does spotting before my period mean something is wrong?"

"What can I do if I’ve experienced multiple miscarriages?"

"How do I know if low progesterone is my problem?"

For answers to these and more, visit our page on Conception FAQ, it’s a helpful resource for anyone trying to understand their fertility journey.

Natural Solutions & Next Steps: Restoring Hormonal Harmony

The good news is that many cases of hormone-related infertility can be improved with natural approaches. Here are some actionable steps you can take:

Track your cycle: Use a calendar or app to monitor ovulation, luteal phase length, and symptoms. This helps identify patterns and possible hormone deficiencies.

Take our free Progesterone Deficiency Questionnaire, It’s a quick way to assess your symptoms and get personalized guidance.

Consider bio-identical progesterone cream: Using a natural cream, such as Natpro Progesterone Cream, can help restore balance and support fertility. Always read about estrogen dominance before starting.

Support overall hormone health: Prioritize a nutrient-rich diet, manage stress, and get adequate sleep. Avoid exposure to xenoestrogens found in plastics and some cosmetics.

If you’ve experienced challenges with fertility or found success using natural progesterone, your story can inspire others. Share your experience or join our community forums for support and encouragement.

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Dec 30, 2025

New to Progesterone Cream

Hello First of all THANK YOU so much for this website - I am blown away by how much information and support is provided. I am new to bioidentical progesterone

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Dec 28, 2025

FDA removes HRT risk warning labels

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Dec 16, 2025

Insulin Resistance: The Hidden Hormone Imbalance & Natural Solutions

Feeling tired, foggy, or struggling with stubborn weight gain—especially around the waist? You might be surprised to learn that these symptoms could be linked to insulin resistance, a condition that affects up to 80% of adults in developed countries but often goes undiagnosed. Insulin resistance is more than just a blood sugar issue; it’s deeply connected to hormone balance, inflammation, and your overall well-being.

What Is Insulin Resistance?

Insulin resistance (IR) means your cells don’t respond properly to insulin, the hormone that helps move glucose from your bloodstream into your cells for energy. When this happens, your pancreas works overtime, producing more insulin to compensate. Over time, this can lead to symptoms like: •Constant fatigue and brain fog •Weight gain (especially around the middle) •Cravings for sugar and carbs •Mood swings and irritability •High blood pressure and cholesterol •Skin issues, bloating, or frequent infections

Left unchecked, insulin resistance can progress to metabolic syndrome, type 2 diabetes, heart disease, and even polycystic ovarian syndrome (PCOS). But it doesn’t have to be inevitable.

How Hormone Imbalance Fuels Insulin Resistance:

Insulin resistance doesn’t exist in a vacuum. Hormonal imbalances—especially low progesterone and high estrogen (often called estrogen dominance)—can make IR worse. Chronic stress, inflammation, and vitamin D deficiency also play a role. The result? A frustrating cycle of symptoms that can impact your energy, mood, and metabolic health.

Progesterone is a powerful natural anti-inflammatory and antioxidant. It helps regulate blood sugar, calms the nervous system, and supports healthy metabolism. Research shows that using a bio-identical progesterone cream, like Natpro, may help break the cycle of insulin resistance and restore hormonal harmony.

Natural Solutions for Insulin Resistance:

Prioritize nutrient-rich foods: Focus on non-starchy vegetables, healthy fats, and quality protein. Limit processed carbs and sugars, which can spike insulin and worsen symptoms. For practical tips, see our Nutrition and Diet guide.Boost vitamin D: Low vitamin D is common in insulin resistance. Aim for a blood level of at least 50 ng/ml. Learn more in our Vitamin D3 resource.Manage stress: Chronic stress raises cortisol and insulin, making IR worse. Gentle exercise, time in nature, and relaxation practices can help.Consider bio-identical progesterone : Many women find relief using 100–200 mg daily. Always read about estrogen dominance before starting progesterone therapy.Stay persistent: Reversing insulin resistance takes time, but small, consistent changes can make a big difference.

Resources & Next Steps

Take our Progesterone Deficiency Questionnaire to assess your symptoms.Read more about insulin resistance and hormone balance on our dedicated page.

Join our community forums to connect with others and share your experiences.

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Dec 11, 2025

Understanding PCOS: Hormone Balance, Symptoms & Natural Solutions

Are you struggling with irregular cycles, unwanted hair growth, or unexplained fatigue? You’re not alone. Polycystic Ovarian Syndrome (PCOS) affects up to 10% of women of reproductive age—and many more experience milder symptoms or hormonal imbalances that often go undiagnosed.

What Is PCOS? Why Does It Matter?

PCOS isn’t just about ovarian cysts—it’s a complex syndrome involving a combination of symptoms: irregular or absent periods, enlarged ovaries with multiple follicles, hormonal acne, weight changes, excess androgens (like testosterone), and even chronic pelvic pain. Many women with PCOS also struggle with insulin resistance, blood sugar issues, and low progesterone levels, which can make symptoms worse over time:

•Irregular or absent periods•Difficulty with ovulation and fertility•Excess facial or body hair, acne, or hair thinning•Weight gain, especially around the waist•Fatigue and mood swings•Chronic pelvic pain

How Hormone Imbalance Drives PCOS Symptoms..

One of the key drivers behind PCOS is a hormonal imbalance — specifically, low progesterone and high androgens. When ovulation is infrequent or absent, progesterone drops, which can trigger a cascade: the body produces more luteinising hormone (LH), which raises androgens and disrupts the menstrual cycle even further. Insulin resistance and inflammation can worsen these imbalances, creating a frustrating cycle of symptoms.

Natural Solutions for PCOS: Steps Toward Balance..

•Vitamin D: Low vitamin D is common in PCOS and may be a key factor. A daily dose of at least 5,000 IU to 10,000 is recommended to bring blood levels to 50 ng/ml or higher. Adequate vitamin D supports hormone balance and can help reduce inflammation.

•Bio-identical Progesterone: Using 150–250 mg per day of a natural progesterone cream, such as Natpro, can help stabilize blood sugar, lower androgens, and support regular cycles.

For more guidance on application, visit our How to Use Progesterone Cream guide.

Inositol and Antioxidants: The B-vitamin inositol, along with L-arginine and N-acetyl cysteine, may help reverse insulin resistance and restore ovarian function.

Nutrition and Lifestyle: Focus on non-starchy vegetables, quality protein, and healthy fats. Avoid processed carbs and sugars, which can spike insulin and worsen symptoms. For nutrition tips, explore our Nutrition and Diet resource and The gut-hormone connection.

Patience and Persistence: It can take several months for the ovaries to respond to these changes. Consistency is key—many women see improvement within four to six months.

Resources to Support Your Journey:

Take our Progesterone Deficiency Questionnaire to assess your symptoms.

Read more about PCOS and hormone balance in our detailed PCOS FAQ.

If you suspect you may have PCOS or are struggling with hormone-related symptoms, know that there are natural, empowering steps you can take. Many women find that with the right support, symptoms can become manageable—and even improve dramatically over time.

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Dec 05, 2025

Progesterone’s Role in Brain Health & Neuroprotection

While progesterone is often discussed in relation to reproductive health, emerging research reveals its remarkable role in supporting brain function and protecting against neurological decline.

Progesterone: More Than a "Female Hormone":Progesterone is not just vital for hormone balance—it’s a key player in brain health for both women and men. Scientists now recognize that progesterone is produced in the brain itself (as a "neurosteroid"), where it helps regulate mood, memory, and even the brain’s ability to repair itself after injury.

Recent studies show that progesterone:•Promotes the growth and survival of neurons (brain cells)•Supports myelin repair, which is essential for efficient nerve signaling•Reduces inflammation and oxidative stress in the brain•May help protect against neurodegenerative conditions like Alzheimer’s and traumatic brain injury

How Does Progesterone Protect the Brain?...Natural progesterone, as your body makes it, interacts with specific receptors in the brain to:•Encourage dendritic growth and synapse formation—key for learning and memory.•Promote the production of calming neurotransmitters, supporting emotional balance.•Help the brain recover from injury by reducing swelling and supporting tissue repair.

One fascinating discovery is that certain brain cells, like Purkinje cells, can actually make their own progesterone. This local production is especially important during times of rapid brain development and after injury.

What Happens When Progesterone Is Low?...Low progesterone levels—whether due to menopause, chronic stress, or other factors—can leave the brain more vulnerable to inflammation, poor memory, and mood swings. Some researchers even suggest that postmenopausal cognitive decline may be partly related to progesterone deficiency.

If you’re experiencing brain fog, forgetfulness, or emotional ups and downs, it may be worth exploring whether hormone balance could help. Our Progesterone Deficiency Questionnaire is a helpful first step.

Natural Solutions for Supporting Brain Health...

•Consider bio-identical progesterone: Many people find that a natural, plant-derived cream like Natpro Progesterone Cream supports overall well-being, including mental clarity and calm.

•Prioritize restorative sleep: Progesterone helps regulate sleep cycles, so addressing deficiency may improve sleep quality—a cornerstone of brain health.

•Eat a nutrient-rich diet: Healthy fats, leafy greens, and quality protein support both hormone production and brain function.

•Manage stress: Chronic stress can deplete progesterone and increase inflammation, so gentle movement, time in nature, and relaxation practices make a difference.

For more on the science, read our page on progesterone and traumatic brain injury, and visit our page on progesterone research papers.

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Nov 30, 2025

⭐ Natpro Sale Ending Today! ⭐

Incase you missed it!

Today is the last day for you to claim 15% off our Natpro 100ml Dispensers. The sale ends at midnight tonight.

How to Claim Your 15% Discount:

•Shop at Organic Products LLC or Natpro-Cream before the 1st December.

•Add Natpro Progesterone Cream to your basket.

•Enter the code Natpro15 at checkout for an instant 15% savings.

No minimum purchase needed—stock up for yourself or share with a friend.

To your good health and a happy year end!

With love, the Natpro family 💚

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Nov 25, 2025

Black Friday Sale Now On!

Our biggest sale of the year is here!

For one week, you can enjoy a 15% discount on Natpro Progesterone Cream—with no minimum purchase required.

This offer is valid from 25th November to 30th November on both our trusted stores: Organic Products LLC and Natpro-Cream

How to Claim Your Black Friday Discount:

•Shop at Organic Products LLC or Natpro-Cream between 25th–30th November.

•Add Natpro Progesterone Cream to your basket.

•Enter the code Natpro15 at checkout for an instant 15% saving.

•No minimum purchase needed—stock up for yourself or share with a friend!

We wish all of you a happy festive season and year end!

To your good health, the Natpro family 💚

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Nov 24, 2025

Exciting News: Our New Online Store is Live!

To all our valued customers,

We’ve heard your requests for more flexibility with payment options and clearer access to usage and dosage instructions, and so we’re delighted to announce the launch of our brand new online store: Natpro-Cream

Our new store was designed with your convenience in mind. You’ll now enjoy:

•More payment methods and options – making checkout smoother than ever.•Easy to understand usage instructions and dose charts.•A modern, user-friendly experience.

Whether you prefer using credit cards, digital wallets, or alternative payment solutions, our new platform has you covered. We’re always striving to make your journey to hormone balance as simple and stress-free as possible.

We know that many of you have shopped with us for years and value the familiarity of our original store. Please rest assured Organic Products remains fully active and available. If you feel more comfortable with the site you know, you’re welcome to continue shopping there as always.

No matter which store you choose, our mission stays the same: to provide education, natural solutions, and support for hormone balance.

Thank you and to your good health!

With love, the Natpro family 💚

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Sep 25, 2025

The Gut Hormone Connection

The connection between gut health, hormonal balance and the role of progesterone in gut health

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Sep 25, 2025

Progesterone Metabolism and Transdermal Supplementation

Progesterone Metabolism and Transdermal Supplementation, progesterone creams

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Aug 20, 2025

Opinions on Dr. Ruscio's views on High Estrogen vs. Estrogen Dominance?

In my ongoing research I came across this page by Dr. Ruscio, DC, on How to Flush Out Excess Estrogen: A Clinician’s Take: https://drruscio.com/flush-out-excess-estrogen/

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Aug 15, 2025

Any *other* sites that support the information given on this site?

I really appreciate all the information on this site, as it has helped me as well as many others with answers to questions that doctors seem oblivious

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Aug 15, 2025

Effect of Losing Weight on Hormone Levels

I have been researching on this site for nearly a decade, yet I have never seen any info on what happens to hormones when we *lose* weight -- specifically,

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Aug 10, 2025

Major questions and clarification needed

First, I really appreciate all the information on this site. It’s certainly information that cannot be found elsewhere, and sadly the OB/GYNs seem to know

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Jul 07, 2025

Medical gatekeeping natural vs synthetic

Medical gatekeeping natural progesterone vs synthetic progestin

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Jul 02, 2025

Progesterone vs Progestin

What is the difference between progesterone and progestin? Interview with Wray Whyte

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Jul 02, 2025

Progesterone Side Effects Video

progesterone side effects video interview

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Jun 27, 2025

Progesterone deficiency

Interview with Wray Whyte on Progesterone Deficiency

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