Progesterone Blog

Jan 03, 2026

Cortisol

I'm not clear on what progesterone does to cortisol levels. Not sure if it's helping mine. I have continuous high cortisol at night and mornings. Yet

Continue reading "Cortisol"

Dec 30, 2025

🌱 Fertility, Infertility & Progesterone

If you are feeling confused or overwhelmed by fertility challenges, or wondering if hormone balance might be affecting your ability to conceive you are not alone—many women and couples face uncertainty, frustration, and a lack of clear answers when it comes to fertility and infertility.

Understanding Fertility & the Hidden Role of Progesterone:

Fertility is a complex dance of hormones, timing, and health. While most people focus on ovulation and sperm health, one of the most overlooked factors is progesterone—a hormone essential for preparing the uterus for implantation and supporting early pregnancy. Without enough progesterone, even a healthy egg and sperm may not result in a successful pregnancy.

Some of the signs of infertility linked to hormone imbalance include:

•Irregular or absent periods•Short luteal phase (the time between ovulation and your next period)•Spotting before your period starts•Recurrent miscarriages•Unexplained fatigue, anxiety, or mood swings•Symptoms of estrogen dominance (bloating, breast tenderness, PMS)

Many women are told that infertility is “unexplained” or simply due to age, but the truth is that progesterone deficiency is a common—and often correctable—cause.

Progesterone Deficiency: Why It Matters for Conception:

Progesterone is produced after ovulation and is vital for thickening the uterine lining and maintaining it so an embryo can implant and grow. If levels are too low, implantation may not occur, or early miscarriage can result. This is sometimes called “luteal phase defect.”

Factors that can lower progesterone include:•chronic stress•excessive exercise•poor diet•age•underlying health conditions like PCOS or thyroid issues.•Environmental toxins and xenoestrogens (chemicals that mimic estrogen).

Common questions about conception include:

"Can I get pregnant if I have irregular cycles?"

"Does spotting before my period mean something is wrong?"

"What can I do if I’ve experienced multiple miscarriages?"

"How do I know if low progesterone is my problem?"

For answers to these and more, visit our page on Conception FAQ, it’s a helpful resource for anyone trying to understand their fertility journey.

Natural Solutions & Next Steps: Restoring Hormonal Harmony

The good news is that many cases of hormone-related infertility can be improved with natural approaches. Here are some actionable steps you can take:

Track your cycle: Use a calendar or app to monitor ovulation, luteal phase length, and symptoms. This helps identify patterns and possible hormone deficiencies.

Take our free Progesterone Deficiency Questionnaire, It’s a quick way to assess your symptoms and get personalized guidance.

Consider bio-identical progesterone cream: Using a natural cream, such as Natpro Progesterone Cream, can help restore balance and support fertility. Always read about estrogen dominance before starting.

Support overall hormone health: Prioritize a nutrient-rich diet, manage stress, and get adequate sleep. Avoid exposure to xenoestrogens found in plastics and some cosmetics.

If you’ve experienced challenges with fertility or found success using natural progesterone, your story can inspire others. Share your experience or join our community forums for support and encouragement.

_____

Dec 30, 2025

New to Progesterone Cream

Hello First of all THANK YOU so much for this website - I am blown away by how much information and support is provided. I am new to bioidentical progesterone

Continue reading "New to Progesterone Cream"

Dec 28, 2025

FDA removes HRT risk warning labels

_____

Dec 16, 2025

Insulin Resistance: The Hidden Hormone Imbalance & Natural Solutions

Feeling tired, foggy, or struggling with stubborn weight gain—especially around the waist? You might be surprised to learn that these symptoms could be linked to insulin resistance, a condition that affects up to 80% of adults in developed countries but often goes undiagnosed. Insulin resistance is more than just a blood sugar issue; it’s deeply connected to hormone balance, inflammation, and your overall well-being.

What Is Insulin Resistance?

Insulin resistance (IR) means your cells don’t respond properly to insulin, the hormone that helps move glucose from your bloodstream into your cells for energy. When this happens, your pancreas works overtime, producing more insulin to compensate. Over time, this can lead to symptoms like: •Constant fatigue and brain fog •Weight gain (especially around the middle) •Cravings for sugar and carbs •Mood swings and irritability •High blood pressure and cholesterol •Skin issues, bloating, or frequent infections

Left unchecked, insulin resistance can progress to metabolic syndrome, type 2 diabetes, heart disease, and even polycystic ovarian syndrome (PCOS). But it doesn’t have to be inevitable.

How Hormone Imbalance Fuels Insulin Resistance:

Insulin resistance doesn’t exist in a vacuum. Hormonal imbalances—especially low progesterone and high estrogen (often called estrogen dominance)—can make IR worse. Chronic stress, inflammation, and vitamin D deficiency also play a role. The result? A frustrating cycle of symptoms that can impact your energy, mood, and metabolic health.

Progesterone is a powerful natural anti-inflammatory and antioxidant. It helps regulate blood sugar, calms the nervous system, and supports healthy metabolism. Research shows that using a bio-identical progesterone cream, like Natpro, may help break the cycle of insulin resistance and restore hormonal harmony.

Natural Solutions for Insulin Resistance:

Prioritize nutrient-rich foods: Focus on non-starchy vegetables, healthy fats, and quality protein. Limit processed carbs and sugars, which can spike insulin and worsen symptoms. For practical tips, see our Nutrition and Diet guide.Boost vitamin D: Low vitamin D is common in insulin resistance. Aim for a blood level of at least 50 ng/ml. Learn more in our Vitamin D3 resource.Manage stress: Chronic stress raises cortisol and insulin, making IR worse. Gentle exercise, time in nature, and relaxation practices can help.Consider bio-identical progesterone : Many women find relief using 100–200 mg daily. Always read about estrogen dominance before starting progesterone therapy.Stay persistent: Reversing insulin resistance takes time, but small, consistent changes can make a big difference.

Resources & Next Steps

Take our Progesterone Deficiency Questionnaire to assess your symptoms.Read more about insulin resistance and hormone balance on our dedicated page.

Join our community forums to connect with others and share your experiences.

__________

Dec 11, 2025

Understanding PCOS: Hormone Balance, Symptoms & Natural Solutions

Are you struggling with irregular cycles, unwanted hair growth, or unexplained fatigue? You’re not alone. Polycystic Ovarian Syndrome (PCOS) affects up to 10% of women of reproductive age—and many more experience milder symptoms or hormonal imbalances that often go undiagnosed.

What Is PCOS? Why Does It Matter?

PCOS isn’t just about ovarian cysts—it’s a complex syndrome involving a combination of symptoms: irregular or absent periods, enlarged ovaries with multiple follicles, hormonal acne, weight changes, excess androgens (like testosterone), and even chronic pelvic pain. Many women with PCOS also struggle with insulin resistance, blood sugar issues, and low progesterone levels, which can make symptoms worse over time:

•Irregular or absent periods•Difficulty with ovulation and fertility•Excess facial or body hair, acne, or hair thinning•Weight gain, especially around the waist•Fatigue and mood swings•Chronic pelvic pain

How Hormone Imbalance Drives PCOS Symptoms..

One of the key drivers behind PCOS is a hormonal imbalance — specifically, low progesterone and high androgens. When ovulation is infrequent or absent, progesterone drops, which can trigger a cascade: the body produces more luteinising hormone (LH), which raises androgens and disrupts the menstrual cycle even further. Insulin resistance and inflammation can worsen these imbalances, creating a frustrating cycle of symptoms.

Natural Solutions for PCOS: Steps Toward Balance..

•Vitamin D: Low vitamin D is common in PCOS and may be a key factor. A daily dose of at least 5,000 IU to 10,000 is recommended to bring blood levels to 50 ng/ml or higher. Adequate vitamin D supports hormone balance and can help reduce inflammation.

•Bio-identical Progesterone: Using 150–250 mg per day of a natural progesterone cream, such as Natpro, can help stabilize blood sugar, lower androgens, and support regular cycles.

For more guidance on application, visit our How to Use Progesterone Cream guide.

Inositol and Antioxidants: The B-vitamin inositol, along with L-arginine and N-acetyl cysteine, may help reverse insulin resistance and restore ovarian function.

Nutrition and Lifestyle: Focus on non-starchy vegetables, quality protein, and healthy fats. Avoid processed carbs and sugars, which can spike insulin and worsen symptoms. For nutrition tips, explore our Nutrition and Diet resource and The gut-hormone connection.

Patience and Persistence: It can take several months for the ovaries to respond to these changes. Consistency is key—many women see improvement within four to six months.

Resources to Support Your Journey:

Take our Progesterone Deficiency Questionnaire to assess your symptoms.

Read more about PCOS and hormone balance in our detailed PCOS FAQ.

If you suspect you may have PCOS or are struggling with hormone-related symptoms, know that there are natural, empowering steps you can take. Many women find that with the right support, symptoms can become manageable—and even improve dramatically over time.

___

Dec 05, 2025

Progesterone’s Role in Brain Health & Neuroprotection

While progesterone is often discussed in relation to reproductive health, emerging research reveals its remarkable role in supporting brain function and protecting against neurological decline.

Progesterone: More Than a "Female Hormone":Progesterone is not just vital for hormone balance—it’s a key player in brain health for both women and men. Scientists now recognize that progesterone is produced in the brain itself (as a "neurosteroid"), where it helps regulate mood, memory, and even the brain’s ability to repair itself after injury.

Recent studies show that progesterone:•Promotes the growth and survival of neurons (brain cells)•Supports myelin repair, which is essential for efficient nerve signaling•Reduces inflammation and oxidative stress in the brain•May help protect against neurodegenerative conditions like Alzheimer’s and traumatic brain injury

How Does Progesterone Protect the Brain?...Natural progesterone, as your body makes it, interacts with specific receptors in the brain to:•Encourage dendritic growth and synapse formation—key for learning and memory.•Promote the production of calming neurotransmitters, supporting emotional balance.•Help the brain recover from injury by reducing swelling and supporting tissue repair.

One fascinating discovery is that certain brain cells, like Purkinje cells, can actually make their own progesterone. This local production is especially important during times of rapid brain development and after injury.

What Happens When Progesterone Is Low?...Low progesterone levels—whether due to menopause, chronic stress, or other factors—can leave the brain more vulnerable to inflammation, poor memory, and mood swings. Some researchers even suggest that postmenopausal cognitive decline may be partly related to progesterone deficiency.

If you’re experiencing brain fog, forgetfulness, or emotional ups and downs, it may be worth exploring whether hormone balance could help. Our Progesterone Deficiency Questionnaire is a helpful first step.

Natural Solutions for Supporting Brain Health...

•Consider bio-identical progesterone: Many people find that a natural, plant-derived cream like Natpro Progesterone Cream supports overall well-being, including mental clarity and calm.

•Prioritize restorative sleep: Progesterone helps regulate sleep cycles, so addressing deficiency may improve sleep quality—a cornerstone of brain health.

•Eat a nutrient-rich diet: Healthy fats, leafy greens, and quality protein support both hormone production and brain function.

•Manage stress: Chronic stress can deplete progesterone and increase inflammation, so gentle movement, time in nature, and relaxation practices make a difference.

For more on the science, read our page on progesterone and traumatic brain injury, and visit our page on progesterone research papers.

____

Nov 30, 2025

⭐ Natpro Sale Ending Today! ⭐

Incase you missed it!

Today is the last day for you to claim 15% off our Natpro 100ml Dispensers. The sale ends at midnight tonight.

How to Claim Your 15% Discount:

•Shop at Organic Products LLC or Natpro-Cream before the 1st December.

•Add Natpro Progesterone Cream to your basket.

•Enter the code Natpro15 at checkout for an instant 15% savings.

No minimum purchase needed—stock up for yourself or share with a friend.

To your good health and a happy year end!

With love, the Natpro family 💚

___

Nov 25, 2025

Black Friday Sale Now On!

Our biggest sale of the year is here!

For one week, you can enjoy a 15% discount on Natpro Progesterone Cream—with no minimum purchase required.

This offer is valid from 25th November to 30th November on both our trusted stores: Organic Products LLC and Natpro-Cream

How to Claim Your Black Friday Discount:

•Shop at Organic Products LLC or Natpro-Cream between 25th–30th November.

•Add Natpro Progesterone Cream to your basket.

•Enter the code Natpro15 at checkout for an instant 15% saving.

•No minimum purchase needed—stock up for yourself or share with a friend!

We wish all of you a happy festive season and year end!

To your good health, the Natpro family 💚

____

Nov 24, 2025

Exciting News: Our New Online Store is Live!

To all our valued customers,

We’ve heard your requests for more flexibility with payment options and clearer access to usage and dosage instructions, and so we’re delighted to announce the launch of our brand new online store: Natpro-Cream

Our new store was designed with your convenience in mind. You’ll now enjoy:

•More payment methods and options – making checkout smoother than ever.•Easy to understand usage instructions and dose charts.•A modern, user-friendly experience.

Whether you prefer using credit cards, digital wallets, or alternative payment solutions, our new platform has you covered. We’re always striving to make your journey to hormone balance as simple and stress-free as possible.

We know that many of you have shopped with us for years and value the familiarity of our original store. Please rest assured Organic Products remains fully active and available. If you feel more comfortable with the site you know, you’re welcome to continue shopping there as always.

No matter which store you choose, our mission stays the same: to provide education, natural solutions, and support for hormone balance.

Thank you and to your good health!

With love, the Natpro family 💚

_______

Sep 25, 2025

The Gut Hormone Connection

The connection between gut health, hormonal balance and the role of progesterone in gut health

Continue reading "The Gut Hormone Connection"

Sep 25, 2025

Progesterone Metabolism and Transdermal Supplementation

Progesterone Metabolism and Transdermal Supplementation, progesterone creams

Continue reading "Progesterone Metabolism and Transdermal Supplementation"

Aug 20, 2025

Opinions on Dr. Ruscio's views on High Estrogen vs. Estrogen Dominance?

In my ongoing research I came across this page by Dr. Ruscio, DC, on How to Flush Out Excess Estrogen: A Clinician’s Take: https://drruscio.com/flush-out-excess-estrogen/

Continue reading "Opinions on Dr. Ruscio's views on High Estrogen vs. Estrogen Dominance?"

Aug 15, 2025

Any *other* sites that support the information given on this site?

I really appreciate all the information on this site, as it has helped me as well as many others with answers to questions that doctors seem oblivious

Continue reading "Any *other* sites that support the information given on this site?"

Aug 15, 2025

Effect of Losing Weight on Hormone Levels

I have been researching on this site for nearly a decade, yet I have never seen any info on what happens to hormones when we *lose* weight -- specifically,

Continue reading "Effect of Losing Weight on Hormone Levels"

Aug 10, 2025

Major questions and clarification needed

First, I really appreciate all the information on this site. It’s certainly information that cannot be found elsewhere, and sadly the OB/GYNs seem to know

Continue reading "Major questions and clarification needed"

Jul 07, 2025

Medical gatekeeping natural vs synthetic

Medical gatekeeping natural progesterone vs synthetic progestin

Continue reading "Medical gatekeeping natural vs synthetic"

Jul 02, 2025

Progesterone vs Progestin

What is the difference between progesterone and progestin? Interview with Wray Whyte

Continue reading "Progesterone vs Progestin"

Jul 02, 2025

Progesterone Side Effects Video

progesterone side effects video interview

Continue reading "Progesterone Side Effects Video"

Jun 27, 2025

Progesterone deficiency

Interview with Wray Whyte on Progesterone Deficiency

Continue reading "Progesterone deficiency"

May 10, 2025

Progesterone and oral health during menopause

I am interested in finding out if there are any benefits from progesterone cream for oral health in menopause. The articles I have read mention synthetic

Continue reading "Progesterone and oral health during menopause"

Apr 25, 2025

Confused about blood test results

Hello, I have recently had blood tests done for estradiol and progesterone on day 5 of my cycle on April 16. i am definitely in perimenopause the last

Continue reading "Confused about blood test results"

Apr 23, 2025

Upping the dose for progesteone Therapy?

Unfortuantely I just posted my qustion under someone else's question. I do apologise as it shouldn't have gone there, so I'll write it here under a new

Continue reading "Upping the dose for progesteone Therapy?"

Apr 22, 2025

​Exhausted from insomnia caused by night sweats

At 34 I lost my first pregnancy due to water breaking at 16 weeks. Second pregnancy required trans-abdominal-cerclage(TAC) placed by surgery at 19 weeks.

Continue reading "​Exhausted from insomnia caused by night sweats"

Apr 14, 2025

Dosage of progesterone for anxiety

I had a hysterectomy a year ago and have been on 1/2 to 1/4 teaspoon progesterone cream, twice a day. No other hormones, only supplements. I am post menopausal

Continue reading "Dosage of progesterone for anxiety"

Mar 29, 2025

No period after 14 days of progesterone

Hi, I have been taking Ona’s 20% 100mg x 2 daily. I’ve had lots of issues that have been on going since having the copper iud (now removed) when I had

Continue reading "No period after 14 days of progesterone "

Mar 27, 2025

Progesterone withdrawal?

I have been on progesterone for close to three years now (and recently have went off of it). I was taking 75mg (but was having weird symptoms and found

Continue reading "Progesterone withdrawal?"

Mar 21, 2025

Colposcopy

Almost 40 on 200mg progesterone for close to a year with magnesium, d3 and k. Had abnormal pap recently and they want colposcopy—- now suddenly bleeding

Continue reading "Colposcopy "

Mar 19, 2025

HRT active ingredients

HRT active ingredients, hormone replacement therapies

Continue reading "HRT active ingredients"

Mar 03, 2025

Treatment for Postpartum Anxiety/Depression/OCD

I have found this website after a deep dive into progesterone as treatment for postpartum mental health disorders and an so grateful for all the information

Continue reading "Treatment for Postpartum Anxiety/Depression/OCD"