How to use the progesterone cream

by Cathy
(Australia)

Hi Wray, I saw a question from one of your readers asking about the latest Dr Mercola information advising people to use progesterone cream in the vagina to stop the build up in fat cells.

I was wondering if you had any more details on this. Excuse the following personal question but I'm sure others would like to know too. If you have a cream and not pills do you try and get the cream right into the vagina somehow or just rub it inside the vaginal lips?? I'm not exactly sure how to administer the cream based on what he said.

Any info would be great. Thanks.

Comments for How to use the progesterone cream

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May 09, 2011
How to Use in Vagina
by: Anonymous

Yes I would like to know also, have read recommendations to apply vaginally but with no instruction.


May 09, 2011
application
by: Anonymous

I also would like a clear answer for this as this could be revolutionary. Wouldn't the vagina area become saturated by the progesterone just as other parts of the body do?

May 10, 2011
How to use progesterone (reply)
by: Gina

I found this info on another page in this site:

Progesterone application methods.

May 11, 2011
How to use the progesterone cream
by: Wray

Hi Cathy Dr Mercola does advocate using it in the vagina in preference to the skin. But in the 15 years I've used it, and advised on it's use, I've not found this a problem, either in myself or others. In fact if I do go through extra stress I cover myself with the cream, including in the vagina. In fact I put some there every night. I do this for a couple of days till I feel 'topped' up. I find the symptom which comes back most readily is labile emotions. Last year I had a great deal of stress, nothing serious, just more of the usual daily stressors, plus working long hours. I used 2tsp per day, which gave me 330mg/day progesterone. I did this for 2 weeks, and during that time I suffered bad oestrogen dominance. I ached in every muscle, joints too, I felt so old! Plus I was not pleasant to be around. My nails had become very weak too, splitting and flaking off. Well at the end of the 2 weeks, I had my strong nails back again, and not an ache left. I normally use about 170mg/day progesterone (1tsp cream), so I think I can safely say my receptors are working fine still! I would not have had the Oestrogen Dominance if they had been turned off by too much progesterone. Or it had saturated the cells. See these papers here and here. Applying the cream in the vagina can be done using a finger or putting the cream in a syringe. Take care Wray

May 11, 2011
what to do????
by: Anonymous

Hello Wray, I find that I'm having spotting three weeks out of the month when I apply internally, I feel cramps and have dried blood and blood. My dr says that the progesterone is building up and that is causing the bleeding...?? I still feel cruddy and I don't know what to do. I'm. Taking my supplements and I'm under heavy stress. I have adrenal exhaustion as well! My hair seems to be coming out again as well!!!!. I get my results for my test again today. I will see what they are.

Thank you for your helpful site! !!!!;).

May 16, 2011
what to do????
by: Wray

Hi there I'm not sure how much progesterone you're using, but if you're having spotting for 3 weeks out of every month, it appears far too little. I recommend 100-200mg/day, dependant on symptoms. Progesterone doesn't cause bleeding, in fact it stops it! MMP's cause bleeding, these are enzymes that break down protein. They play a role in the breakdown of endometrial tissues at the end of the menstrual cycle. Oestrogen stimulates MMPs. Progesterone suppresses MMPs. It?s only when progesterone levels drop at the end of the cycle that the MMP?s can get to work, and break down the lining causing our monthly bleed. If there is sufficient oestrogen in the body it will stimulate more lining, and so the cycle goes, see here and here. But if progesterone is low due to anovulation, spotting and/or bleeding can continue. Please consider increasing the amount of progesterone you are using, for more info see How to use progesterone cream. But before you do please see our page on Oestrogen Dominance. It's really not essential to use progesterone in your vagina, it's an option. It's certainly good for dryness and inflammation if that's a problem. I've found supplemental progesterone excellent for adrenal stress. The adrenals first make progesterone which they then convert into cortisol. If they are under stress they'll rob other sources, notably the ovaries. This then effects the reproductive cycle, in fact stress causes anovulation, which of course means no progesterone is made. A vicious cycle. Progesterone does help hair, but so do many nutrients. I'm running out of space so will start a new comment below. Take care Wray

May 23, 2011
Vaginal use
by: Wray

Hi there I've had a rash of queries asking about vaginal use, it seems to be the in place to use it. And yet Dr Dalton was prescribing progesterone pessaries to her patients 60 years ago, so there's nothing new about it at all. The rectum is another place it can be applied, suppositories are normally given for this. Although there is no difference in composition between a pessary and a suppository, only the name varies. The cream can be applied in the vagina with either with a finger or syringe, there are also fizzy vaginal tablets too. I can't say I relish the thought of those! We do have a page on Delivery systems which gives all the options. Take care Wray

May 23, 2011
Fatty tissue
by: Wray

Hi there The vagina has no fatty tissue, as does the skin. So the reasoning goes there can't be a build up there. But as progesterone is so beneficial if applied directly to the skin, it seems a waste not to use it there. I've found that it's effect is far quicker too, then waiting for it to circulate. For instance for aches and pains, it's the best thing for burns, it soothes immediately, excellent for piles if applied directly to them, minor cuts and bruises, leg ulcers and more. It's excellent for the face too, see here. Take care Wray

May 23, 2011
Part 2 to 16 May post
by: Wray

Hi there Please consider taking 5000iu's/day vitamin D, 2000mg/day N-actyl cysteine, 2000mg/day inositol, 2-3mg biotin and 100mg thiamine (B1). Please check your iron levels, and there is some evidence the amino acid lysine is beneficial too, see here. Vitamin D is vital for the anagen phase of hair growth, see here, here and here. Please consider having a test done, for more info see the Vitamin D council and GrassrootsHealth websites. Thanks for the kind words! Take care Wray

Oct 04, 2011
Insomnia
by: Sandra

I read Dr Mercolas article about applying progesterone cream in the vagina. I am interested because I know I have low progesterone from a saliva test. I also have insomnia. I fall asleep easy but wake up after 4-5 hrs and cannot go back to sleep. When I take progesterone cream applied to the skin it wires me and I cannot fall asleep as I usually do, and I have a much worse night of sleep, which is normally not good anyway. It doesn't matter if I apply it morning or night. I get that wired effect. I first applied the cream transdermally about 8yrs ago and it worked nicely for several months (I lost weight and I slept better), but after that I noticed it affected my sleep and I was gaining weight. I was hoping applying the progesterone cream in the vagina, it would take a different route and work better.

Wray, any comments from you about why the progesterone cream causes me to feel wired would be appreciated. It seems it causes my cortisol to rise. Thanks.

Oct 06, 2011
Insomnia
by: Wray

Hi Sandra The vagina is a good place to apply progesterone, particularly for dryness or inflammation. It's also helpful for Candida. But it matters not where you put it, on the skin, in the vagina, nose, ears, it travels rapidly around the body, carried on red blood cells. The vagina has an ample supply of blood vessels, so it enters the circulation very quickly. The wired feeling was an Oestrogen Dominance symptom, you were evidently using too little progesterone. Perhaps the 20-40mg/day most people recommend? I suggest using 100-200mg/day, more if symptoms are severe. We do have further info on our page How to use progesterone cream. Progesterone is excellent for sleep, see here. It's essential to make progesterone the dominant hormone, it's only possible to do this by using high amounts. So if you should consider using it again, please make sure you use sufficient. I prefer the cream, but there are other Delivery systems you might like to look at. If enough progesterone is used it suppresses cortisol, which incidentally is made from progesterone within the adrenals. Stress causes cortisol to rise, stress also drops progesterone levels, simply because it's being converted to cortisol. So given sufficient supplemental progesterone, the stress effect is lessened and cortisol drops. In fact progesterone is an excellent anxiolytic, see here, here and here. Take care Wray

Dec 05, 2012
progesterone
by: Anonymous

hi there can this also help with Pcos, im not sure what dosage I should use for that was goering you head some better info.

Dec 06, 2012
progesterone
by: Wray

Hi there Progesterone can help PCOS, but not alone. Large amounts of antioxidants are needed too to reverse the PCOS. The page I've given you gives a list of these, and how much progesterone is needed. We also have more general info on our page How to use progesterone cream. Please have a vitamin D test done, as this is often low in PCOS. For more info on vitamin D levels, test kits etc see the Vitamin D Council, GrassrootsHealth and Birmingham Hospital. Blood levels should be 70-100ng/ml (175-250nmol/L) and not the 30ng/ml (75nmol/L) most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although recent research indicates it should be 10,000iu's per day, see here. Please also look through our page on Insulin Resistance, as this often occurs with PCOS. Take care Wray

Aug 27, 2013
Progesterone cream
by: Anonymous

Yes, my doctor also told me to insert the progesterone cream directly into the vaginal with an applicator. 1/2 full, 2 grams for 3 times a week. It is the same applicator you use for yeast infection you buy in any drug store over the counter. I hope this help you.

Sep 24, 2013
help with progest cream
by: lynsey

Hi, any help would be great.. im using the now progesterone cream, 20 mg a day for 2 weeks. libido came back almost immediatley but now cystic acne is breaking out worse and i am constantly sooo tired. I have been applying morning and night. thinking about doing just the nightime dose. My naturopath diagnosed me with low progesterone, i am also on a dim supplement along with angus castus and maca. I dont really want to higher the dosage as i feel its only going to make me more tired, what am i doing wrong?!

Sep 27, 2013
help with progest cream
by: Wray

Hi Lynsey Using too little progesterone, it's only stimulating oestrogen. There's more info on our Oestrogen Dominance page. Agnus castus also has oestrogenic properties. One study found mild ovarian hyperstimulation syndrome occurred in the luteal phase, see here. Some have found maca affects them. It apparently has no affect on oestrogen or testosterone levels according to this one paper, see here. And yet this paper said it increased oestradiol levels, see here. It does appear to increase diastolic blood pressure slightly too, see here. These are two more papers here and here. We do have a page on Acne you could look through. And another on How to use progesterone cream. Take care Wray

Sep 27, 2013
still struggling
by: Lynsey

Thanks for the quick response wray.. so what dosage of the cream should I be applying to you think? im quite a small girl.. about 110 pounds.. maybe less. So if i start having bad reactions just carry on with a high dose?
I actually have a few issues in all honesty im a bit of a mess!! ive had acne on and off for about 6 years. I seem to have different types, I have constant congestion, blocked pores, mainly on forhead and on cheeckbones and sides of face around hairline... never seem to go away no matter wot i use or dont use topically.. then i also get very deep painful cysts mainly on chin around mouth and jawline and neck. I went on spiro for about a year i looked and felt amazing, hair got thick, skin was clear.. and then i developed melasma on my upper lip.. i took myself straight off it... and acne now back along with the melasma, and i really want to correct this imbalance to cure these because im getting progressively more depressed as the weeks go by and im on this extreme healthy diet and not seeing the slightest change. I have never been on birth control, i would like to try it for my acne but now im scared that because i have melasma it could make it worse. I assume the spiro caused the melasma by highering my estrogen levels? any help would be great,pretty desperate at this point, very unhappy and not looking forward to anything because of my skin issues.


Sep 29, 2013
still struggling
by: Wray

Hi Lynsey I've answered all these queries on your other page here. Take care Wray

Oct 06, 2013
End of my rope
by: Anonymous

Hi, I have low progesterone and my period suddenly stopped 9 months ago. I got scans that ruled out pcos and despite taking the natural cream and acupuncture I got sik of the weight gain that I went on Yasmin. The side effects were so severe that I went off it after gaining 5kgs in 2 months...(note that I had cut out wheat, gluten, caffine, refined carbs, dairy, all sugar and exercise 7days a week). Even after stopping the pill and I'm back to square one....I cannot lose weight even eating the way I do and excercising and no period gain. I'm back on the natural progesterone cream 1/4 tsp twice daily and on vitex and getting acupuncture. Should I be putting some extra cream inside my vagina or am I using enough cream? When will I start seeing results in the weight department? It's really distressing me beyond words because I'm being so strict...and I'm only 27 HELP!!!

Oct 06, 2013
End of my rope
by: Anonymous

Hi, I have low progesterone and my period suddenly stopped 9 months ago. I got scans that ruled out pcos and despite taking the natural cream and acupuncture I got sik of the weight gain that I went on Yasmin. The side effects were so severe that I went off it after gaining 5kgs in 2 months...(note that I had cut out wheat, gluten, caffine, refined carbs, dairy, all sugar and exercise 7days a week). Even after stopping the pill and I'm back to square one....I cannot lose weight even eating the way I do and excercising and no period gain. I'm back on the natural progesterone cream 1/4 tsp twice daily and on vitex and getting acupuncture. Should I be putting some extra cream inside my vagina or am I using enough cream? When will I start seeing results in the weight department? It's really distressing me beyond words because I'm being so strict...and I'm only 27 HELP!!!

Oct 09, 2013
End of my rope
by: Wray

Hi there The weight gain was caused by using too little progesterone. I see you're back on the same low amount too. You're probably getting 20-40mg/day. A minimum of 100-200mg of cream should be applied. Too little progesterone stimulates oestrogen, which does cause weight gain. Oestrogen causes cells to proliferate, including fat cells, see here, here, here, here and here. Although a scan showed you don't have PCOS, you could still have it. Please scroll to the end of the page and see all the tests which should be done and ruled out before saying you don't have it. A scan just confirms there are no cysts on the ovaries. Please consider taking the nutrients listed on the page, many initiate ovulation and help regulate the cycle. Please have a vitamin D test done. Take care Wray

Oct 10, 2013
confused
by: Lynsey

Im wondering why your dosage advice is so high wray?
are u saying that ppl should be on atleast 100mg of the natural cream.. im on now progesterone and on the tub it says 2 pumps a day which would give you 40mg.. 100 mg seems an awful lot, and its vry hard to rub in or put that much in your vagina.
Can you confirm that this is infact what your saying?
lynsey

Oct 10, 2013
confused
by: Wray

Hi Lynsey I've answered all your questions before. But it's evident the cream you use does not absorb well. Some women use over 1000mg/day, see these comments here, here,here, here and here. Take care Wray

Dec 30, 2013
Vaginal progesterone cream
by: Jules

I see that the best way to apply the cream is vaginally. Is there a specific over the counter brand to use? All the ones I have seen and used have not instructed you to use them in this way. I would rather not have to get it compounded. I agree with not getting enough on the typical 20-40 mg a day. I have been instructed to use this amount by several doctors over the years and it really hasn't helped with my severe insomnia. I would like to try vaginally and a higher dose on my own. Any advise would be appreciated.

Jan 02, 2014
6 months post benzo :-)
by: Coralashley

Hello, it's been a long time since I posted. I do have a question.
But 1st an update:
I'm off the remeron (AD) and have been for over 40 days now :-) Praise the Lord! I'm on the Wilson's Temperature Syndrome t3 therapy and that is helping so much! I'm on 50mg progesterone pill and 30mg of progesterone cream, 1 x a day.

So here comes the question... my doctor sent me a urine kit to collect for my hormone levels. On the instructions it said to stop applying progesterone cream to your vagina, if you were doing so, and to apply it somewhere else on the body. So I did that and continued applying it away from the vagina for about a week..
During that week I've experienced less sleep, harder to fall sleep and some anxiety after 4pm and while I'm lying in bed, etc.
Do you think it's b.c I was having w/ds from me not putting the cream around my vagina?

Last night I went to go to bed at 10pm and layed in bed till after Midnight and then I thought wait the only thing I've done differently is I've changed where I put the progesterone cream.
So even though I had already put some on my inner arms, I went ahead and put some around my vagina area and took another progesteron pill and went to bed after 2am and then woke up at 6:30am.

You see last night when I was just lying there I felt very tired and wasn't thinking about anything, i was peaceful, but just couldn't fall sleep all the way.

Thanks for your insight! I've missed chatiing with you!
Hugs, Coralashley

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