Progesterone therapy has been practiced for over 50 years in the treatment of a wide variety of symptoms and diseases that are hormonally related. During this time no adverse side affects have been reported. Some people have benefited from it continuously for over 30 years.

There is no evidence to suggest it is possible to overdose using progesterone therapy.

Hormones are chemical messengers and can only work once inside the nucleus of a cell. To get into the nucleus the hormone needs a carrier which is called a receptor. Receptors are very specific, they will only transport the hormone for which they are made. Progesterone receptors will not transport the synthetic progestogens into the cell nor will they transport progesterone itself if there is adrenalin in the blood.

The level of progesterone varies in women from approximately 5mg per day in the first half of the monthly cycle up to 50 mg per day in the second half. During pregnancy the placenta produces up to 40 times the highest amount made when not pregnant. Men make from 5 to 15mg per day on a continuous basis.

Here's an important word of caution...

Tests to find the level of progesterone in the blood of women are generally of little value for a number of reasons...

• the ovary secretes progesterone in small spurts and the amount can vary within half an hour
• low levels have been found in women who are not ovulating
• if adrenalin is present or the blood sugar is too low even high levels of progesterone cannot be used
• after a large meal the level of progesterone drops
• the level drops during the long nights experienced in northern latitudes
• progestogens contained in the Pill or HRT lower the level of progesterone

Progesterone therapy is usually administered in a cream or oil base, which means that it will be carried in the blood on a red blood cell membrane. Often tests only check the plasma which would show up little or no progesterone.

So what can you do for reliable results?

Saliva tests are generally more reliable. However, if you are a woman and if a blood test is your only option then make sure this is done during the 5 to 10 days before your next period. This is to check whether ovulation has occurred, as the level should then be at its highest point.

To find out why the saliva test is the only reliable one (and more)...

...please click here for a specialist's comments.

A blood test is not a necessity. Simply trying progesterone therapy and seeing its effectiveness in dealing with your health problems is the easiest course of action as it is inexpensive and risk free.

Progesterone therapy can be administered in many forms...

• transdermal creams varying from under 1% to 10% in strength, which are an effective, slow release form
• sublingual oil or tablets, giving a quick release so not suitable for long term use
• injections, very effective at treating emergencies such as epileptic, migraine or asthmatic attacks, but not for long term use
• suppositories, again a fast release form so not suitable for long term use
• orally administered capsules, which are ineffective, as up to 90% is destroyed by the digestive system and the liver before reaching the receptor sites

Transdermal creams are the most commonly used form of progesterone therapy for a number of reasons, some of which are...

• ease of use
• cost effectiveness
• can be used over a long term
• direct benefit to the skin, making the use of other moisturizers unnecessary.

When using progesterone therapy it is essential to start on a high dose. Some practitioners give 2500mg/day for very severe cases of post natal and manic depression, PMS, panic attacks, temporary psychosis etc.

After the initial high dose, which should bring relief in anywhere from three days to three months, it may gradually be reduced until the reappearance of symptoms.

This indicates the level of progesterone needed. As it is the precursor to the stress hormones any extra stress will require increased levels of progesterone therapy.

Once started on progesterone therapy you will become sensitive to the level needed on a daily basis. However, here is some additional guidance for you...

When to Use Progesterone Therapy

Continuous application

How Much Progesterone Cream to Use

For the first three months use sufficient progesterone cream to ensure the application of 2000mg (2 grams) of progesterone per month (read labels as its important to know the concentration of the cream you are using). Thereafter the amount may be reduced subject to the reappearance of symptoms.

Progesterone cream can be used at any time of the day and, if preferred, on more than one occasion. It can be applied to any part of the body.

It is effective in reducing pain when applied to painful areas (for example, arthritis or burns) or for period pains etc.

Please note... The figures below showing quantities of progesterone cream are based on creams with a concentration of 3.33% progesterone as, for example, is the case with a 2oz (60 gram) pot or tube of cream containing 2000mg (2 grams) of progesterone.

Women

1. Menstruating
   • use almost 1 teaspoon (4.25 millilitres - ml) per day
2. Post menopausal
   • use almost half a teaspoon (2 ml) per day
3. Hysterectomies
   • use almost half a teaspoon (2 ml) per day
4. Pre-pubertal, pubertal and peri-menopausal
   • use either half a teaspoon (2 ml) or almost 1 teaspoon (4.25 ml) per day, depending on the cycle chosen

Men

Use from 1/8 of a teaspoon (600 ml) to almost 1/2 a teaspoon (2 ml) per day

How to Apply Progesterone Cream

Rub the required amount of cream thoroughly into the skin on any part of the body.

Important note for women... If you have been on HRT (hormone replacement therapy) or have a naturally high level of estrogen, progesterone will make you more sensitive to the estrogen in your body. Because of this, for the first two or three months the symptoms caused by excessive estrogen may affect you. If this is the case it is advisable to increase the daily application of progesterone cream, with the advice of your health specialist, until these symptoms have gone.

The main symptoms of excessive estrogen are...

• breast tenderness
• bloating/weight gain from water retention
• spotting or a temporary reappearance of your periods
• hypoglycemia
• bruising
• depression
• chronic fatigue
• hot flushes

If you are on HRT and wish to discontinue it, the gentlest course is to taper off taking the pills/patches/inserts over a period of 2-6 months. Adjust the tapering off period according to the severity of previous symptoms and how long the HRT was taken.

For more information on what are often, but wrongly, perceived as progesterone side effects click here.

Simple Progesterone Test

An elevated progesterone level induces an increase in body temperature. Women can measure their temperature by using a thermometer. A rise in progesterone is indicated by about a 0.4 degree Fahrenheit increase and a fall of progesterone, triggering menstruation, indicated by a decrease in temperature.

A thermometer can also help in determining if you are progesterone deficient during pre-menopause years. (Post menopause women are not ovulating and menstruating and have constantly low progesterone levels so progesterone level changes will not occur.) Your temperature should rise at ovulation and remain high until a day or two so before the end of the cycle and the start of menstruation. Fluctuations may occur due to a "double ovulation". Although this is rare it is possible within three days of initial ovulation or due to sickness.

If your temperature never rises (indicating no ovulation) or consistently drops several days after ovulation and stays low for days thereafter it is very probable that your progesterone levels are not being adequately maintained. Low progesterone levels can contribute to miscarriages and osteoporosis and numerous other symptoms of estrogen dominance. To verify your findings the only reliable method is saliva hormone testing.

"...saliva hormone testing is more convenient, less stressful, more cost-effective, and more representative of the bioavailable fraction of hormones in blood than serum hormone testing. When hormones are delivered topically, serum hormone testing grossly underestimates the bioavailable fraction of hormones in blood and tissue hormone uptake and response..." Dr David Zava.

To read more and to find out why the saliva test is the only reliable one please click here.

A General Observation about drugs

Some drugs may be dispensed with once progesterone therapy has been started, most notably the anti-depressants. Always taper off slowly and with the advice of your health specialist.

Any additional stress, good or bad, can cause your symptoms to recur. If this should happen then increase the daily application until they have gone.

If you would like to find out more about progesterone therapy please click here.