Can progesterone provide the base for an effective pimple and acne cream?
Acne is an inflammatory disease of the skin which affects 85% of teenagers, most of whom are male. It can continue into adulthood.
Interestingly enough it rarely affects people outside the Western nations. According to Cordain et al there is an absence of acne in the Kitavan Islanders of Papua New Guinea and Ache hunter-gatherers of Paraguay. They believe this is due to their diets, which, being natural and unprocessed, have a much lower glycaemic index than Western diets. They are also more physically active than Westerners. They do not have insulin resistance, obesity, hypertension, diabetes, or heart disease.
Too much sugar, or foods in the diet which convert to glucose in the body, cause an increase in insulin and insulin resistance, leading to more sugar consumption.
This in turn causes androgens to increase, high androgens in turn cause acne.
The sebaceous glands are stimulated by androgens produced in the skin itself. Often elevated androgen levels are not found in blood or urine from patients with acne.
DHT (dihydrotestosterone) is made in the sebaceous glands from testosterone, through the action of 5 alpha-reductase. Progesterone inhibits 5 alpha-reductase.
In women it appears that DHT is made from androstenedione, the precursor to testosterone.
In searching for an effective pimple and acne cream it should be kept in mind that there are as many treatments as there are theories about what causes it. A few common factors have been found...
Natural remedies, with special reference to progesterone as a potentially effective pimple and acne cream...
Please see the web page on insulin resistance for information on supplements to take.
In addition take daily 100mg zinc. This high dose should be taken for approximately three months, when the dose should be reduced to 15mg/day. Acne has often cleared after using a high dose zinc supplement, especially needed by men, as the sperm contains more zinc than any other part of the body.
It is beneficial for the skin to take 5ml Omega 3 fish oil and/or 15 to 60ml flax oil and 5ml GLA from evening primrose oil.
The probiotics are another essential for clear skin. Be sure to take a supplement containing at least 10 billion bacteria per dose.
Taking a parasite cleanse, digestive enzymes and betaine hydrochloride (HCl) to improve digestion, is something to consider.
Please see here for more information on Nutrition and Diet.
Clin Cosmet Investig Dermatol. 2012;5:135-40
Zinc ascorbate has superoxide dismutase-like activity and in vitro antimicrobial activity against Staphylococcus aureus and Escherichia coli
J Eur Acad Dermatol Venereol. 2010 Jul;24(7):763-7
Oxidative stress in acne vulgaris
Br J Dermatol. 2008 Nov;159(5):1086-91
Tissue and blood superoxide dismutase activities and malondialdehyde levels in different clinical severities of acne vulgaris
J Clin Invest. 2007 December 3; 117(12): 3979; 3987
Monosaccharide-induced lipogenesis regulates the human hepatic sex hormonebinding globulin gene
J Steroid Biochem. 1984 Jan;20(1):437-9
The effect of progesterone administration on sex hormone binding globulin binding capacity in women with severe premenstrual syndrome
J Drugs Dermatol. 2008 Jul;7(7 Suppl):s2-6
Exp Dermatol. 2008 August ; 17(8): 633&Mac226; 639
The vitamin D pathway: a new target for control of the skin&Mac226;Äôs immune response?
Experimental Dermatology Jun 2007, Volume 16 Issue 7, Pages 618 - 625
Vitamin D and the skin: an ancient friend, revisited
Medical Hypotheses Volume 69, Issue 5, 2007, Pages 1080-1084
Acne vulgaris: Nutritional factors may be influencing psychological sequelae
J Am Acad Dermatol. 2007 Aug;57(2):247-56. Epub 2007 Apr 19
The effect of a high-protein, low glycemic-load diet versus a conventional, high glycemic-load diet on biochemical parameters associated with acne vulgaris: a randomized, investigator-masked, controlled trial
International Journal of Dermatology 2007, Volume 34 Issue 6, Pages 434 - 437
Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris
Journal of the American Academy of Dermatology, Volume 52, Issue 2 , February 2005, Pages 360-362
High school dietary dairy intake and teenage acne
Semin Cutan Med Surg. 2005 Jun;24(2):84-91
Implications for the role of diet in acne.
International Journal of Cosmetic Science. 27(5):255-261, October 2005
Nicotinamide - biologic actions of an emerging cosmetic ingredient
Journal of Cosmetic Dermatology. 3(2):88-93, April 2004
Nicotinic acid/niacinamide and the skin
Arch Dermatol. 2002 Dec;138(12):1584-90
Acne vulgaris: a disease of Western civilization.
Archives of Dermatology Vol. 130 No. 3, March 1994
Acne vulgaris in premenarchal girls. An early sign of puberty associated with rising levels of dehydroepiandrosterone
Acta Derm Venereol. 1992;72(3):217-9
Serum levels of vitamin D metabolites in isotretinoin-treated acne patients
Obstetrics & Gynecology 1991;78:103-107
Effects of sex steroids on skin 5 alpha-reductase activity in vitro
G Ital Dermatol Venereol. 1990 Sep;125(9):363-7
[Sexual hormones and acne in adolescent women]
British Journal of Dermatology Volume 119 Issue 5 Page 627-632, Nov 1988
Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid
Archives of Dermatological Research Volume 276, Number 6 / September, 1984 Pages 401-405
The local antiandrogenic effect of the intracutaneous injection of progesterone in the flank organ of sexually mature male syrian golden hamster
Archives of Dermatological Research Volume 269, 281-290, Number 3 / December, 1980
Inhibition of testosterone metabolism and lipogenesis in animal sebaceous glands by progesterone
Acta Derm Venereol Suppl (Stockh). 1980;Suppl 89:27-31
The influence of sex hormones on acne.
British Journal of Dermatology Volume 100 Issue 6 Page 687-692, June 1979
The effect of topically applied progesterone on sebum excretion rate