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Progestrone for PPD

by LJ
(Seattle WA USA)

Hi,

I would like to get some guidance and help from any fellow friends who have used progesterone in postpartum to prevent PPD and help balance hormones. Some background: I had horrible PPD with my son 4.5 years ago. I had to take an antidepressant to recover but it took a while for progesterone and hormones to balance after his birth. I've since educated myself and much more versed in understanding my body and how my hormones affect me physically and mentally. I've read Katrina Dalton's book, NatroTechnology books, Dr Ray peats work on progesterone and also read books on perimenopause/PMS by Dr Lara Briden. Anyhow, long story short, I started using Natpro progesterone in my Luteal phase around last summer. Found it magical and very helpful with PMS.

That being said, I want to be proactive with my second pregnancy this time, and ensure that I am doing this right. Per the resources I've read and worked on, those recommend a progesterone shot of 100 mg within 24-48 hours of delivery and continue until symptoms resolve. I want to know if cream of 100-200 mg could substitute this? The length of this treatment varies on symptoms. So wondering how continuing progesterone - lets say 2 months? could impact one's period? I had my period soon after pregnancy even with breastfeeding. So curious if anyone has had experience with this. And is cream dosage equivalent to that of a IM injection? I've seen some posts say that it is, but still would like to verify. Having cream on hand helps me dodge all the hoops i would have to jump to get a traditional OB to prescribe progesterone after birth.

If someone has had experience of this, please let me know.

Comments for Progestrone for PPD

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Feb 20, 2026
 Pregnancy and PPD
by: Joy

Hi there

I am hoping that others will share their experiences.

Childbirth and breastfeeding both affect hormones, as you know. Some women are affected more than others. If progesterone has been used correctly — usually 100–200 mg of a good organic progesterone cream, such as the one you are using will help greatly. It is often recommended to continue progesterone therapy after the birth if there is a history of PPD.

The use of progesterone may disrupt the monthly cycle initially, but the body generally adjusts. This can take one to two months, and in some cases longer. As you mentioned, it depends on the individual.

Natpro is a 3% cream. You would need to check the strength of the injection to compare percentages.

Please read the following pages if you have not done so already. How to Use Progesterone Cream and Pregnancy.

Please also ensure that your Vitamin D3 level is optimal, as a deficiency can reduce the effectiveness of progesterone.

Best wishes.

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