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Progesterone injections

by Tonya
(Goudeau,La)

Will progesterone injections help me? I have had two miscarriages in the past three years. Right now, I am 12 weeks pregnant. I have a weak cervix and my ob doctor will be performing a Cerclage at my 13th week and I will be starting progesterone at 16 weeks.

Do you think this is too late to start or should I have already been put on it earlier. Also will this progesterone injection taken weekly help me to not go into preterm labor?

Comments for Progesterone injections

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Nov 20, 2008
 Progesterone injections
by: Wray

Hi Tonya. With two miscarriages, you should have been given progesterone as soon as you knew you were pregnant. Unfortunately it's only after 3 miscarriages that progesterone is thought about. It's the first 3-4 months that are critical as by 16 weeks the danger of an early miscarriage is not as great.

So yes, you should have been given it earlier, but it's never too late. Progesterone does help prevent preterm labour too. Progesterone injections are large and by all accounts painful. The normal 1ml dose contans 50mg progesterone, which is usually dissolved in sesame oil and preserved with benzyl alcohol. At once weekly doses I believe this is far too low, you should be using 100-200mg/day. Please read the papers given below, as it's been found that vaginal progesterone is equally as effective as IM injections. Hope this helps, take care Wray

http://humrep.oxfordjournals.org/cgi/content/abstract/7/2/168
http://humrep.oxfordjournals.org/cgi/content/abstract/11/10/2085
http://www.future-drugs.com/doi/abs/10.1586/17474108.1.2.173?cookieSet=1&journalCode=eog
http://www.medicalnewstoday.com/articles/104216.php
Oct 18, 2009
 progesterone injections
by: Anonymous

While you were broaching the subject of progesterone injections I wanted to share my experience with you. I am a female of 35 years and I have a friend who is a male of 37 years. Both our mothers were given progesterone injections in the 70s. I don't know in what dose or the title of the injection at the time but needless to say that I was found to have a double cavity uterus which stopped me having children until I received an operation to rectify it. My friend has a deformed penis which cannot be changed and I wonder if it could have been caused by these injections that our mothers took.

I don't want to scare anyone as I'm sure the chances of it happening are very small but I have read studies that say it can cause this sort of thing but it seems that it has not been researched an awful lot. So just please think carefully before taking any drugs in pregnancy.
Oct 25, 2009
 Progesterone injections
by: Wray

There is so much confusion between natural and synthetic progesterone, even amongst professionals. I would have to know what injections your mother has received to comment. There is no doubt now that the synthetic progestins cause such problems, two examples...

1. medroxyprogesterone acetate: You should never take Provera during the first 4 months of pregnancy. During this formative period, even a few days of treatment with Provera might put your unborn baby at increased risk for birth defects. If you take Provera and later discover that you were pregnant when you took it, discuss this with your doctor right away.

2. levonorgestrel:
However, if you become pregnant with the system in place you should have it removed as soon as possible. You might want to consider having an abortion. Your doctor or clinic will advise you.

Progesterone, not a progestin, is given after IVF, ART etc to support the development of the embryo. Take care, Wray
Feb 02, 2010
 My experience
by: mamagreentree

I am currently taking progesterone in the form of p17 and I'm at 23 weeks and doing great. My son was born at 28 weeks 11 years ago before this treatment was available. This type of progesterone therapy is not started until 16 weeks at least as it is meant to prevent early labor. Before I started the p17 injections, I had a placental abruption with hemmorhaging. I am feeling great now and don't even require bedrest. My cervix actually lengthened. Detailed ultrasound has shown that this baby has perfectly developing internal organs. P17 has been used in this way for about 5 years and no babies have been shown to be born with anatomical defects. Even if there was a slight risk, keep in mind that premature birth carries high risks for a baby such as blindness or other vision problems, learning disabilities, underdeveloped kidnies, asthma, hearing loss, or death. My son who was born three months early has asthma, muscle hypotonia, Asperger's syndrome, sensory integration disorder, and a mood disorder. Maybe coincidence, maybe not. I'll do whatever I can to keep this baby from spending the months my son had to struggling for his life.
Jun 23, 2010
 Frequent bleeding
by: Anonymous

I am 32 year old Nigerian woman, curently on posgesterone injection to stop bleeding during pregnancy. I bleed quite alot and frequently now even during the course of the treatment which is more than before I started the treatment.

This makes me to take more of the injection which stops the bleeding after about 10 days of administration. Only for the bleeding to return in about five days after it stopped

I am not sure of the condition of my baby, and I don't know what is wrong with my health. Can you help?
Jun 23, 2010
 Frequent bleeding
by: Wray

Hi there You shouldn't be bleeding at all. It makes me feel the progesterone you are using is either not a high enough dose. Or it's 17-hydroxyprogesterone caproate, which is often used in place of progesterone for maintaining a pregnancy, but it's synthetic. Please look on your container and see which you have. To prevent bleeding you need at least 200-400mg/day progesterone, does the injection give you this? Generally they are 50mg each, which means you should be using 4 a day, painful! A progesterone cream is as effective, especially if some is used in the vagina too, as this travels immediately to the uterus where needed. I would suggest you try this in preference and please increase the amount to that suggested above. Take care Wray
Aug 06, 2010
 Progesterone in early pregnancy
by: Chidi

I'm going to be 29 yrs in December. I got married Feb. 2009 and have been trying to get pregnant since then. Initially I had irregular periods (once every 2 months). I was given a drug (can't remember the name now) to push out my period and clomid for ovulation which I continued to take. I got pregnant in October but during the 6th week when I did a scan they noticed the foetus wasn't growing the way it should. Shortly after probably 2-3 weeks later, I started bleeding and had to have an evacuation. In Feb 2010 I was put on clomid again and the other drug as i had not seen my period (d evacuation was done on the 27th of December 09). I saw my period Feb 20th which lasted for 7days. In April I confirmed I was pregnant (8 weeks gone by the time I went to the hospital) upon doing a scan they noticed the foetus was like that of a 4 week pregnancy while I was almost 9 weeks gone. I think it was termed Blighted ovum. I started bleeding 27th of April and had an evacuation the next day. I was advised to start taking Folic Acid which I have been taking and on June 6th 2010, I saw my period, July 4th also I saw my period (without taking any drugs) now I have just confirmed I'm almost 5 weeks pregnant and I'm thinking of taking progesterone injections but my doctor says it won't make any difference as it has not been scientifically proven to prevent miscarriages.

I need your advice badly. Should I still go ahead with the injection? How do I take it? How many miligrams do I need to take? And the exact name the injection is called so I can make sure I'm being given the right one.

I am so scared, I do not want to go through another MS/Evacuation again.

Thanks in anticipation.
Aug 07, 2010
 side effects
by: Sophia in Florida

I started hydroxy-progesterone at 16 weeks, I am now 22 weeks. I have been experiencing severe skin rashes to labal area, inner thighs, and excessive weight gain. Could this be a side effect?
Aug 08, 2010
 Progesterone in early pregnancy
by: Wray

Hi Chidi There are nutrients which help ovulation, these should have been tried first before giving you clomid. Your ovaries are obviously in need of help, and not with drugs. It could be you have a vitamin D deficiency, this causes anovulation. Please have a test done, as a low level also affects the growing foetus. For more info please see the Vitamin D council web site. A lack of progesterone also affects ovulation, as there's a feedback loop from the ovaries to the hypothalamus, to the pituitary and back to the ovaries. I don't understand why your doctor says it has not been scientifically proven that progesterone prevents miscarriages. Without progesterone no woman would carry a child to term! It's vital for pregnancy. Please see our web page on Pregnancy. There are plenty of papers describing studies done using progesterone for both miscarriages and pre-term births. It has also been shown other forms of progesterone delivery are as good, if not better than injections, which are painful. So please read the papers to reassure yourself. We have helped many women who have only used progesterone cream to have healthy, full term babies. The amount given is normally a minimum of 200mg/day, occasionally higher. I can't give you the name of the injection, as there are a few on the market, your doctor could advise on that. But I would advise against them, as they are painful, and pregnancy should be a peaceful, happy affair. And rather use suppositories which are commonly used, or a cream. Take care Wray
Aug 09, 2010
 side effects
by: Wray

Hi Sophia I take it you are getting 17-hydroxyprogesterone (17OHP) which is a naturally occurring metabolite of progesterone? And not 17-hydroxyprogesterone caproate, which is a synthetic progestin also used to prevent miscarriages and pre-term births. Often the same term is used for both compounds. No adverse side affects have been reported with the use of 17OHP, which is produced primarily by the adrenal glands, and increases in the third trimester. I would always favour the use of progesterone though, and let the body metabolise it naturally into 17OHP. You might like to see our web page on Pregnancy. I can't tell if you are having an allergic reaction to OHP, but have you noticed an increase in the symptoms shortly after you get the shot? I think a visit to a dermatologist might be an idea. Take care Wray
Aug 10, 2010
 Success
by: Baby Iz

I had 3 consecutive miscarriages 2 years ago. My doctor had me take progesterone pills after ovulation and once I became pregnant ended up on the injections. I had a wonderful pregnancy and now have a little girl. I truly believe that this was the key to maintaining my pregnancy. Good Luck!!
Oct 25, 2010
 Progesterone and miscarriages
by: ade

I got married in april 2010, discovered i was pregnant on the 24th of July, (I have a regular menstrual cycle) started bleeding on the 1st of August and had to have an evacuation on the 3rd of august as I had an incomplete abortion. On the 8th of September I had my period and on the 12th of October I was confirmed pregnant again. I, however, started bleeding on the 19th October. A scan was carried out fetal pole was said to be very small and viability could not be ascertained. Pending further scan I was placed on progestorone injections for five days which lapsed on the 23rd. Could a progesterone deficiency be responsible for my miscarriage?
Oct 28, 2010
 Progesterone and miscarriages
by: Wray

Hi Ade Yes it could well be a lack of progesterone which caused the miscarriage. Particularly as you were given injections. But I'm puzzled they only gave you 5, if there is any risk of miscarriage, they should be continued to the 3-4 month stage. Although there are other delivery systems which are as affective, and far less painful. For more info please see this page on Progesterone application methods. We've helped many women with the cream, which is far more versatile than the injection too. Please see our page on Pregnancy for more info on how to use it. Take care Wray
Dec 22, 2010
 Post ICSI
by: Anonymous

HI,Wray. i was put on progesterone im injections post embryo transfer,now due to excessive pain i could not afford to take them anymore. I've not confirmed abt my pregnancy yet. I called my dr & informed abt the pain due to injections & she asked me stop them & use pessaries twice daily each consists of 300mg progesterone. Is this how i should continue or do i require anything else?
Jan 06, 2011
 Starting Injections
by: Joy

Hi! I am 11 wks pregnant and will be starting the progesterone injections in 5 wks. I had been told by my ob that cerclage would be the best treatment but the perinatologist wants to do injections and hold off on cerclage until my cervix begins to thin.

This makes me a nervous wreck. I have a 6 yr old son that was born at 27 wks. He required long term o2 use and still uses flovent daily. I am just curious to hear how other have done and if I should get a 2nd opinion....I go to a large military hopsital so that maybe difficult. Thanks
Jan 07, 2011
 Post ICSI
by: Wray

Hi there I'm sorry about the delay in replying but I've been travelling. Progesterone injections are very painful, so it doesn't surprise me you want to stop. Pessaries are a far better option, she's given you a huge dose! The injections are normally 50-100mg each, unless you've had many miscarriages I don't believe you need as much as 600mg/day. But it certainly won't harm you. The vagina absorbs progesterone very quickly, and studies have found it travels to the uterus within minutes. There is nothing else you require, but we do have a page on Pregnancy. You might like to read through this as it explains how to use it during pregnancy. If you have any injections left, instead of wasting them, I suggest you 'inject' it onto your hand and then rub it into your skin. It will absorb well, as the injections are a combo oil/progesterone mixture. For more info see our page on Progesterone application methods. Take care Wray
Jan 09, 2011
 Progesterone injections
by: ESRC

I am 34 years old. My husband and I decided to to start trying to get pregnant in 2003. After trying from February to December, I could not get pregnant. I had an HSG (hysterosalpingogram) done to discover there was fluid blcking flow of an egg from one of my ovaries to my fallopian tube. I repeated the same test in 2009 to find out I was pregnant. I went into preterm delivery at 20 weeks. My little girl lived for 3 1/2 hours. The idea of going to a perinatologist was introduced to me during the pregnancy but I never acted on it. Now I'm 24 weeks pregnant, under going progestrone injections and my cervix is still long. I'm grateful for my second chance at motherhood. The injections are painful based on which nurse injects you and how long you have been undergoing the injections. I was told to get some cortisone for the skin irritation. God bless all you expecting mothers!
Jan 11, 2011
 Progesterone injections
by: Wray

Hi there Progesterone injections are painful, which is why pessaries/suppositories are used more often. They are equally as effective, if not more so, as the progesterone travels within minutes to the uterus where it's needed, particularly if used as a pessary. Progesterone creams are affective too. Please see our page on Pregnancy. Take care Wray
Jan 11, 2011
 Starting Injections
by: Wray

Hi Joy Why he only wants to give you the progesterone in 5 weeks I don't understand. Yes you had a pre-term birth, but if you are at risk for this, it would be far safer to give it to you at the beginning of pregnancy. And you don't need injections, which are very painful, pessaries are as affective, and cause no pain. We do have a page on Pregnancy. Please read through it, particularly the papers, you'll see the effectiveness of pessaries used for possible pre-term births. But I suspect you have a vitamin D deficiency, your son's early birth, coupled with his use of flovent, makes me think this is the problem. As a lack of vitamin D reduces the benefits of progesterone, it would be advisable to use both. Please have a vitamin D test done, for more info see the Vitamin D council website. Please read these papers too, here, here, here and here. Also these papers here and here. Take care Wray
Feb 01, 2011
 why so late?
by: Anonymous

I delivered a 23 weeker and miscarried at 12 weeks. The doctor wants to give me progesterone shots starting at 16 weeks. Does that seem a little late in the pregnancy? My fears are that I might not make it that far without the help of the progesterone!
Feb 11, 2011
 progesterone shot synthetic
by: excited and worried

I read your previous answers to other's questions and have one of my own. In 2009 I gave birth to my son at 26 weeks, he passed away after 30 minutes or so of life due to an infection. The doctor felt that I must have had a pin hole leak in water bag which allowed my natural bacteria to enter amniotic sac and cause infection. I had no other issues. I am now 20 weeks pregnant and went for my detailed ultrasound with perinatologist who suggested 17-p weekly injections. You made an earlier comment about it being synthetic and could cause birth defects. Should I not be taking this version and ask for natural progesterone? My regular doctor didn't feel I really needed injections, but also felt they would not hurt so suggested I take perinatologist's advice. What are your thoughts?
Feb 19, 2011
 why so late?
by: Wray

Hi there I couldn't agree more with you! In fact I recommend starting the progesterone well before falling pregnant. Oestrogen Dominance often occurs when first using progesterone, not what any woman needs when pregnant at 16 weeks. I simply don't see the reasoning either, the riskiest time is the first 2 months. All 5 of my miscarriages occurred between 6 to 8 weeks. Progesterone injections are by all accounts painful, I see no need for them. Suppositories or a cream work equally well. I've helped many women who've had recurrent miscarriages, one who also had a pre-term birth like you, who've sent me pictures of their babies, proof that the cream works! Please consider starting it before you fall pregnant, and do look through our page on Pregnancy too. Take care Wray
Feb 19, 2011
 progesterone shot synthetic
by: Wray

Hi there If it's 17OHP which is a naturally occurring metabolite of progesterone it's fine. But often 17OHP caproate is used, which is synthetic. Please make sure which one it is. I would agree with your doctor, that your pre-term birth was not caused by a lack of progesterone, and therefore is not needed. And I also agree it won't harm. Progesterone injections are by all accounts painful, and I can see no reason for giving them. I would also recommend using progesterone daily to keep the level up, rather than weekly. Having helped many women with miscarriages, I've found the cream is as effective as the injections. Another option which is often used by specialists are suppositories. Please consider these two, rather than inflicting pain on yourself! We do have a page on Pregnancy you might like to look through. Take care Wray
Mar 29, 2011
 Loss
by: Anonymous

I just turned 41 today and 3 weeks ago I suffered my 5th miscarriage in 6 years. Every single time my doctors have told me my progesterone levels are to low and give me progesterone suppositories to increase my progesterone. I always seem to lose the pregnancy around 6 or 7 weeks. Why can't they put two and two together and give me progesterone shots? Is it to early to give the shots as soon as I find out I'm pregnant? Me and my Husband are devastated everytime we lose another one. We have two healthy children already, a 13 year old Son and an 8 year old Daughter. Everyone tells us we should thank God we have them but it's easy for people to say that when they haven't been through a loss like ours.
Apr 04, 2011
 URGENT
by: Anonymous

I am 6 weeks pregnant,i suffered miscarriage once,and now iwant to commence taking injection of progesterone 3AP.Should i first see my doctor or start it straight,i don't want to loose this pregnancy.
Apr 06, 2011
 next procreation
by: Dorcas

I'm 30yrs,Currently,i'm on progesterone injection and in my 11wk.I had miscarriage in 22wk of my first pregnancy which the Dr. Said is due to cervical incompetency.He recommend that my cervic be tight at 13wk.I'm scared cause my cervic is 5cm that it might happen before the tighing.Moreover is it possible to get concieve again after using progesterone.
Apr 08, 2011
 Progesterone injections
by: Anonymous

Hi, I have a question. I am currently 4w6d pregnant and had a misscariage in Jan. 2011, I was 10 weeks with a progesterone level of 9. I was given one injections of progesterone and a week later had an u/s that measured a 7 week old fetus and no heartbeat. Since I am pregnant again i started weekly injections at 3w6d, my base progesterone was 12.5. I am worried that once a week is not enough from what I have researched. The problem is my doctor will not recheck my progesterone and will only do weekly injections. How can I convince her that I think I need more injections or suppositories? Or is once a week enough to sustain pregnancy? thank you for any response.
Apr 20, 2011
 Loss
by: Wray

Hi there I also had 5 miscarriages, but in two years, so know how you feel. Progesterone suppositories are to my mind better than shots. The dose of the injection is not as high, and it's a very painful one. It appears they are not giving you sufficient progesterone. If you keep having miscarriages, and they've ruled out a genetic problem, then I would recommend you use 200-300mg/day. Occasionally 400mg/day is given, are you using this much? I also always recommend starting it before pregnancy. Progesterone initially stimulates oestrogen, and it's best to get over this phase prior to falling pregnant. We do have a page on Pregnancy, which explains how and when to use to. Please have a vitamin D test done, this is vital for both conception and a successful pregnancy. It's also vital for a growing foetus, see here, here, here, here and here. Another vital nutrient for the foetus is taurine, see here, here and here. Take care Wray
Apr 20, 2011
 URGENT
by: Wray

Hi there I'm sorry this is such a late reply, but I don't have the time to answer all queries when I'd like to, in fact it's now taking me about 12 days to do them. I wasn't aware you could get the progesterone injections without seeing your doctor, as they normally need a script. Progesterone injections are very painful, suppositories or creams are as effective. We do have a page on Pregnancy you might like to read through. Take care Wray
Apr 20, 2011
 next procreation
by: Wray

Hi Dorcas If you're concerned about your cervix, why don't you speak to your doctor? And yes it is possible to conceive again after using progesterone. Besides, we make far more in our pregnancies than we normally use in a supplement. Over 400mg/day in the last trimester, and that doesn't stop us falling pregnant again. We do have a page on Pregnancy you might like to look through. Take care Wray
Apr 20, 2011
 Progesterone injections
by: Wray

Hi there I don't agree with once weekly injections, progesterone is best used a minimum of twice a day. We do have a page on Pregnancy you might like to read. It gives the options used for miscarriages and how to use progesterpne. I've found the creams and suppositories are as effective as injections and far less painful too. How to convince her I don't know, but if you're concerned change doctors, or get some suppositories or a cream, the cream is readily available on line. It is possible to give yourself the injections, can you suggest this to her? But I can see what her answer will be! I do hope you sort it out soon. Take care Wray
May 10, 2011
 can progesterone injections cause the death of a fetus?
by: Anonymous

Hi! I had a bad rash with progesterone injections, and also gain alot of weight also some swelling, after 17 weeks of being pregnant, My baby died inside of my belly do you think it can be caused by progesterone injections?
May 12, 2011
 Injections not painful
by: Anonymous

I recieve the injections once a week and I am 20 weeks pregnant now. I don't think they are painful at all. Its a shot. Takes all of about 2 seconds to get.
Jun 09, 2011
 My experience
by: Anonymous

In 2007 I had my son at 27 weeks pregnant. He will be 4 yesrs old tomorrow. He has no complications and is very healthy! I am currrently 34 weeks and 5 days pregnant. I have been receiving progesterone shots since 16 weeks. The shots aren't painful to me and I have not had any side affects. No excessive weight gain, rashes, etc. I have only gainec 12 pounds the whole pregnancy. My cervical length is still long so all in all I have had no problems. I wish you ladies well on your experience. I just think it works well for some people and not for others.
Jul 08, 2011
 Progesterone and Ibuprofen
by: Anonymous

I am currently 27 weeks pregnant. I was complaining of pelvic pressure so my doctor did an internal ultrasound and found that my cervix was on the short side. It measured 2 something. A couple days later, on a Friday I went back and they did another internal ultrasound and my cervix was even shorter (1.7) I was also one cm dilated. I was given steroid shots for the babies lungs. Then the following week I was started on weekly progesterone injections and Ibuprofen. The ibuprofen is a 600 mg tablet and I have to take one pill every 6 hours. I am unsure what this does for the baby. I was at risk for preterm labor, but at my doctors appointment last on this past Thursday, after one shot and one day of taking ibuprofen my cervix was back to a 3 and I was not dilated. What does ibuprofen do for preterm labor?
Sep 02, 2011
 PROGESTERONE ADVICE
by: AYISH

I HAVE HAD 6MCR IN 2 1/2 YRS AT 5-7 WKS. THE DOCTOR SAYS WILL GIVE ME A PROGESTERONE SHOT NEXT TIME I MISS MY PERIOD, BUT I NEVER HAD A PROGESTERONE LEVEL TEST. HAD A NEGATIVE AUTO IMUNNE DISEASE, DIABETES, ETC TESTS. IS IT NOT BETTER TO KNOW THE PROGESTERONE LEVEL BEFORE THE SHOT?
I AM GETTING WORRIED.
Sep 19, 2011
 Injections versus suppositories
by: Isha

Dear Wray, I hope that you are still answering questions, so i will try my chance. I am currently 26 weeks pregnant with a shortening cervix. Last week i took myself to the hospital as i was having pains, turns out that i was contracting and my cervical length went down to 1.5! Since then i have been at home on strict bed rest. Currently, i take progesterone 400 mg twice a day. I was previously using it rectally but have recently started using them vaginally. I would like to know whether the injections 17p are more effective than the suppositories? Alternatively, would it be more effective to use both the suppositories and then also the injections in combination. lastly, is it just as effective to use the suppositories vaginally as rectally?

Sorry for so many questions, i hope i do hear from you soon! Many thanks.
Sep 27, 2011
 to increase progesterone
by: karuna

I am having cysts on ovaries, took clomid 50 mg for two cycles cyst size increased both times, harmone level during mid period of life cycle is 1,2, LH 8.8 During ovulation time, Estrogen 250 (recent) taking prometrium tablet for progestrone to increase but still now increased to 0.9, still taking metformin and vitamins.

Will my progestrone will increse by taking injection, in getting pregnancy how much time it will take? I want an early child i am 26 years of age kindly tell me how to increase the progesterone. Will I have any problem if pregnancy is positive? Please advice what other precautions can be taken for early pregnancy and to improve progestrone i am following the advices of doctor.
Oct 07, 2011
 severe anxiety and depression
by: Anonymous

This is my second pregnancy, but since my first son was born at 36 weeks gestation, my doctor has put me on 17P progesterone injection. While my first pregnancy was one of the happiest experiences of my life, this time around I am suffering from severe anxiety at night causing a lack of sleep and severe depression during the day with a fear of the approaching evening. I have received about 7 weeks of injections so far and my doctor and I discussed taking me off of the progesterone. I am really hoping that the progesterone injections are the cause of my sudden and severe mood change. Has anyone else experienced these symptoms using the progesterone injection?
Oct 15, 2011
 Anxiety
by: Olivia

I'm into my 26 week of my third pregnancy and I'm on my 10th 17p shot. The first pregnancy my son was born at 32 weeks and went through a 5 week NICU stay. The second I had a miscarriage at 10 weeks. This time they decided the shot was important for me to take. My issue, like anonymous before me, is the mental side effects. Before I started receiving the shots I had minor anxiety but it was controllable. Every week I feel as if my anxiety gets worse and its almost unbearable. I'm worried because the anxiety is effecting the lives of myself, my son and my husband but I don't want to risk my unborn son's life because I discontinued the shot. Something has to give though. My OB said anxiety wasn't a side effect but the nurse who administers the shot says other wise. I don't know who to talk to or to ask!
Oct 17, 2011
 Re: severe anxiety and depression
by: Anonymous

In continuing my post from the 7th, my doctor advised me to discontinue my progesterone shots, however, my symptoms have not subsided and it has been two weeks since my last injectioin. Does anyone know how long it takes for the progesterone to leave the body? Only then will I know if this is the true reason for my mental side effects.
Dec 09, 2011
 suppositories or cream an alternative to P17 shots?
by: Amy

I am 36. This is 5th pregnancy, but I have only 2 boys - 1 born at 36 weeks and fine and the other born at 39, however I was dilated to 6 cm the entire last 4 weeks. The other 2 pregnancies were not full term - 1 was considered a "chemical pregnancy" that ended before 4 weeks and the other was found at a 12 week ultrasound to not have lived past 9 weeks.

I am terrified of the painful shots. I'm currently at week 21 and haven't started yet because I had decided I was maybe not going to do that. I have to bring my boys with me most of the time if I'm going to get them, and I hate to do that in front of them too as they are so young.

Are there creams or suppositories I can tell doctor that I"m more comfortable with?
Jan 07, 2012
 Shots and vit D
by: Kelly

I've been receiving the progesterone shot since I was 3 wks now I'm 16wk. My last miscarriage was at 20 wks. I'm also on vit D3 supplement, 5000IU a day. So far so good. Your page and info are very accurate and quite helpful. It's nice to find accurate info.
I would say to anyone considering the shot. Weigh the pros and cons. For me the pros outweighed any cons. Just remember all medicines can cause a reaction. Everyone reacts differently. Be aware of the symptoms and keep an eye out for the symptoms.
I started the shots knowing if I needed to there were other forms available. Reducing the pain of the shots can be done with a little technique.
Good luck to you all
Jan 07, 2012
 Progesterone to Support Early Pregnancy
by: Amber

Hello,
I just took a home pregnancy test and the result was positive. I have had two miscarriages and one blighted ovum in the past four years. All of these pregnancies reached roughly 7 weeks before I experienced spontaneous abortion.

I have PCOS and have been told by severel OB/GYNs that my condition should not cause miscarriage but may only inhibit me from becoming pregnant. But recently I was told by a nutritionist, who has dealt with PCOS on a personal basis, that progesterone inserts during the first trimester would keep me from having another miscarriage.

I agree with this, but I am afraid that the OB I'm seeing now will not be willing to prescribe the inserts. They were very slow to act with regards to my last pregnancy and subsequent miscarriage. I have used progesterone cream in the past to help regulate my cycle and was wondering if using the cream now would help prevent a miscarriage. I can only assume that my several miscarriages are the cause of low progesterone levels.

I should also add that I have one living child who just turned 11, and had a miscarriage a year before having her. So including this new pregnancy, I have been pregnant 6 times since 1999.

I'm sorry if it seems as though I'm rambling. I am just very nervous and worried. My husband and I want another child very badly. Any advice would be greatly appreciated.

Thank You
Jan 22, 2012
 Does Protogest and Crinone stops uterine contractions after orgasm?
by: Anonymous

I wonder whether progesterone injections imped contractions of the uterus. I was unwise and now I worry I may have affected the chances of the embryo!
This is a frozen cycle following ICSI.

There seems to be different advice on whether it is OK to have an orgasm after ET and after how long.

Today is my Day 6 and I have a long wait to find out....

Could it be that the Prontogest (100 per day) and Crinone 9 x day) make uterine contractions stop after orgasm so I dont need to worry?
Jan 25, 2012
 progesterone injections
by: Anonymous

I am curently 16 weeks with a cervical length o 3.2. I stared my weekly progresterone injections and I keeping my fingers crossed all goes well. I had a short cervix with my last pregnancy but with bedrest carried until 38.5 weeks (healthy boy). I am hoping the weekly shorts maintain my cervix and I deliver full term. with my first i went in preterm labor at 23 and at 30 weeks and it was a very anxious time. anyone received progresterone with a short cervix and did it maintain you during your pregnancy?
Feb 02, 2012
 any update on progesterone injections
by: Anonymous

wanted to know if anyone is on progesterone injections and how they are doing so far in their pregnancy?
Feb 03, 2012
 Prescribed Hydroxyprogesterone Caproate Injection and Scared
by: AG

I was just prescribed the Hydroxyprogesterone Caproate Injection to begin taking today @ 19wks 2days after delivering at 36 weeks previously and a miscarriage at 8 weeks prior to successful delivery.

With my previous delivery, I went into full labor at 35 weeks 4 days and it was stopped with injections at the hospital and I was sent home. The next night my water broke and the following morning delivered a very healthy 6lb, 11oz boy, 20.5 inches. I'm a small person and I'm wondering if I didn't just go into labor because my body knew he was ready and could handle much larger.

Now my doc is trying to put me on a synthetic injection that only has an 18% risk reduction percentage for preterm delvier up to 37 weeks and unknown side effects on the fetus, certainly unknown long term.

Current pregnancy is going well, baby measuring to size (actually 2 to 3 days ahead since 10 weeks - just like my son who eventually measured almost a full week ahead by the last US).

If I don't listen to my doc and something goes wrong early, I'll hate myself. If I do something, possibly unnecessary and do harm down the road, I'll hate myself. Any suggestions/advice?

Mar 09, 2012
 Should I get the progesterine shot or not?
by: Cas

I was 17 years old when I had my first child and he was born at 36 weeks, in the NICU for 10 days and was 5 lbs 7 oz. But is perfectly healthy today and was the healthiest in the NICU at that time. I was traveling by train a lot, lacking food, and very stressed with my boyfriend being so far away in the army. I was 17 years old when I got pregnant and 18 when I had him. I was also smoking marijuana and cigarettes the first 3 months I was pregnant everyday, which I didn't know I was pregnant then when I found out I stopped immediately. 4 years later I'm pregnant again, I'm 22 years old and the doctors want me to get the progesterine shot starting at 16 weeks (which I am right now) and get it every week until 36 weeks i believe. I am scared because after researching I don't know any long term effects and I don't want to have a bad reaction to the shot, and also don't want to go get a shot every week 30 minutes away. I need advice and I need help deciding if it is best if I get the shot or not? Please help and give any advice, I need to make up my mind soon. Half of me wants to and the other half doesn't want to.
Mar 11, 2012
 Should I get the progesterine shot or not?
by: Wray

Hi Cas I don't understand why they want you to have progesterone now. It should be given before conception and up till about 3-4 months. You are now past the stage when miscarriages are more likely. Injections are painful by all accounts, and often a synthetic progestin is given, instead of progesterone. Please make sure it's not one of these. There are many other alternative Delivery systems, vaginal suppositories are usually prescribed by doctors, although the creams are just as effective. We do have a page on Pregnancy you could look through. Take care Wray
Mar 25, 2012
 16 SHOTS OF PROGESTERONE 4 MORE TO GO!
by: Anonymous

Hi Im 27yrs old and pregnant with my 3rd child. My first pregnancy at age 16with a boy I went into labor at 24wks adn was admitted to hospital and placed on magnesium I delivered @ 26wks he lived for 2wks and passed away.

I then got pregnant at 23 with my daughter went to dr appt @32wks and I was dilated to 5 was admitted to hospital and placed on procardia they released me @34 weeks I had her exactly a week later @ 35 weeks and she was 5pds 15oz. She came home with me and is healthy as ever one of the brightest in her class.

So this is my thrid pregnancy and its a boy! My doctor started me on progesterone at 16wks only side effect I've noticed is swelling at the injection site pain and itching. I started dilating at 29 weeks and was admitted to the hospital for 24hrs for steroid shots then released with no restrictions. I am now 32wks and 2days. I have 4 more shots to get they dont want to stop them until I ma 36 weeks. I actually believe the shots work miracles. This is the first pregnancy I've had that i havent been put on bedrest and thats a relief in itself. My baby currently weighs 4pds 10oz and I still have 8wks! I hope this helps I recommend the progesterone shots for anyone. But ny question is how long after I stop the shots do people normally go into labor?
Mar 29, 2012
 16 SHOTS OF PROGESTERONE 4 MORE TO GO!
by: Wray

Hi there Hi there I'm delighted the progesterone injections have helped. Although I do admit I would far prefer to use a cream or suppositories, no pain with those. Your own body will also be making progesterone. So when they stop the shots, it's not until these decline, and other factors rise, will you go into labour. No one can tell when this will be, other than knowing the 'normal' time for delivery. We do have a page on Pregnancy You could look through. Take care Wray
Mar 29, 2012
 high risk pregnancy
by: CHBUNNY

Hello, I'm about 7 weeks pregnant had a previous miscarriage 2yrs. ago. had little spotting 2weeks ago. no pain. every now and then have a little brownish discharge when I wipe. I have the progesterone injections 6 in a box don't know how often to apply them can somebody help me please...ASAP
Apr 02, 2012
 high risk pregnancy
by: Wray

Hi CHbunny The injections are normally given daily, or once a week. What did you doctor tell you? And how many mg or progesterone is in each? Normally 200-600mg/day is given for threatened miscarriage. We do have a page on Pregnancy you could look through. You might like to look at this page on Delivery systems for alternatives the the injections. Take care Wray
Apr 03, 2012
 Serious Side Effect?
by: M.

I have been taking Hydroxyprogesterone Caproate by weekly injections Since i was 17 Weeks along my current pregnancy. My Previous daughter was born at 29 1/2 weeks prematurely and had to be In Nicu weighing 2ibs for about 3 months until she Gained enough Weight (6ibs) to come home. With that being said, With this Current pregnancy which is my second 5 years later, my doctor suggested i start with the progesterone to reduce the chances of this baby being born prematurely. So i've been doing so, right now im 29 weeks pregnant and 2 weeks ago i started having weird symptoms early in the mornings when i wake up, it consists of my chest having a Dry Feeling, Tightening feeling at the same time (while i lay) and when i try drinking water, it doesn't seem to help, i get up and walk around to see if it goes away but then i get shortness of breath, minimal but i do. Another Symptom i've been having is that my arms and hands are swollen, almost the feeling when your arm sleeps because of lack of blood circulation. I am not sleeping reclining on my arm, it just awkwardly happens when i wake up in the mornings. Today, it was both my arms and hands, The Top my my hand and Fingers were so swollen and Purple almost and not to mention it hurt when i tried rubbing it. i sat up and felt better as if my blood circulated down and its just what it needed. In General Can someone That's taken this medication Before Please tell me if they have had anything similar to this happen to them i need reasurance, my doctor says its normal? so i did research of my own and found this :

http://www.ehow.com/about_5595932_hydroxyprogesterone-caproate-side-effects.html
Apr 03, 2012
 Serious Side Effect?
by: M.

I have been taking Hydroxyprogesterone Caproate by weekly injections Since i was 17 Weeks along my current pregnancy. My Previous daughter was born at 29 1/2 weeks prematurely and had to be In Nicu weighing 2ibs for about 3 months until she Gained enough Weight (6ibs) to come home. With that being said, With this Current pregnancy which is my second 5 years later, my doctor suggested i start with the progesterone to reduce the chances of this baby being born prematurely. So i've been doing so, right now im 29 weeks pregnant and 2 weeks ago i started having weird symptoms early in the mornings when i wake up, it consists of my chest having a Dry Feeling, Tightening feeling at the same time (while i lay) and when i try drinking water, it doesn't seem to help, i get up and walk around to see if it goes away but then i get shortness of breath, minimal but i do. Another Symptom i've been having is that my arms and hands are swollen, almost the feeling when your arm sleeps because of lack of blood circulation. I am not sleeping reclining on my arm, it just awkwardly happens when i wake up in the mornings. Today, it was both my arms and hands, The Top my my hand and Fingers were so swollen and Purple almost and not to mention it hurt when i tried rubbing it. i sat up and felt better as if my blood circulated down and its just what it needed. In General Can someone That's taken this medication Before Please tell me if they have had anything similar to this happen to them i need reasurance, my doctor says its normal? so i did research of my own and found this :

http://www.ehow.com/about_5595932_hydroxyprogesterone-caproate-side-effects.html
Apr 03, 2012
 I hope it works!
by: Mybz

Hello,I'm 32 and have had one previous m/c @ 11 weeks. I am now pregnant and @ 5 weeks my progesterone level was low. My Dr. prescribed the suppositories (messy) and after 4 days he decided the my progesterone was still "dangerously low". I am at a "4" and he would like me to be at a "20". So he wrote me a script for the Progesterone ingection in oil. My vial is 500mg/10ml and my Dr. Wants me to inject 50MG every day till 12 weeks so I'm doing only 1ml. That's probably why it doesnt hurt as much. I'm a little sore at the injection site hours later but It's nothing I can't live with. He said this should bring my numbers up within 48 hours. I really hope he's right. I don't go in for lab work till a week from today.
Apr 07, 2012
 Serious Side Effect?
by: Wray

Hi M I wouldn't recommend 17 OHP-C as it's a progestin, often used for pregnancy complications in place of progesterone. 17-hydroxyprogesterone (17-OHP) is a naturally occurring metabolite of progesterone. Whereas 17-hydroxyprogesterone caproate (17-OHP-C), is a synthetic progestin also used to prevent miscarriages and pre-term births. Often the same term is used for both compounds. No adverse side affects have been reported with the use of 17-OHP, which is produced primarily by the adrenal glands, and increases in the third trimester. But 17-OHP-C I would not recommend, as there are safety concerns about it's use. I would always favour the use of progesterone though, and let the body metabolise it naturally into 17-OHP. There is no evidence to date of any adverse side effects to the foetus while using progesterone during pregnancy. And it's more potent that 17-OHP-C, see here, here, here, here, here and here. One of the critical factors for me, one which is overlooked completely by prescribers of 17-OHP-C, is because it's a progestin, it's not metabolised into the all important natural metabolites of progesterone. One in particular is allopregnanolone, possibly even more important than progesterone itself. See the side effects of 17-hydroxyprogesterone caproate here and here. We do have a page on Pregnancy you could look through, and this one here. Your symptoms are not normal to me and I feel you should have a follow up with your doctor. Take care Wray
Apr 07, 2012
 I hope it works!
by: Wray

Hi Mybz Progesterone injections are often advised, although I would prefer to use suppositories or a cream in preference! I would be interested to hear if your level has come up. Normally the minimum given for miscarriages is 200mg/day up to 600mg/day. One woman wrote in recently saying her doctor had given her 1600mg/day! He obviously wasn't taking any chances. If you want to check your levels we do have a page on Hormone Testing. And you might like to see our page on Pregnancy too. Take care Wray
Apr 10, 2012
 Just started Progesterone injections...or so I thought...
by: Anonymous

I just started Progesterone injections today (the plan is 16wks - 36wks) in an effort to try carry this pregnancy to term. I have had three previous pre-term births at 32, 35, 33 wks.

I see that you highly recommend natural progestrone, but I just looked on my precription and I see that it is infact Hydroxyprogesterone Caproate. I tried to look at the previous links to studies, but I don't have a medical background and I find the studies results a little hard to decifer. In laymans terms, what are some of the cons to using these injections instead the natural? What if my healthcare provider or insurance company will only prescribe the Hydroxyprogesterone Caproate?

Now, the doctors in my clinic are not all in agreement that these injections will help me in my situation, as I have Uterus Didelphys, which is the reason for my pre-term labor. They say that it's worth a shot and it won't hurt anything, but that there have never been studies of progesterone injections specifically done on women with this kind of uterine deformity.

Just looking for some research to advocate to my doctors as to why I should have natural progesterone over the synethic Hydroxyprogesterone Caproate. Thanks!
Apr 11, 2012
 progesterone 200 mg
by: Joe

Hi,
Mine is a different story from rest of you i am 36 year old and this is my third pregnancy, well my hubby was little reluctant on having this one so in a emotional moment i took a dose of mifepristone which is known to block the mechanism of progesterone in the body but God has been kind,48 hours after consuming mifepristone i went for a scan as i was too scared to lose the baby and on top of that getting him/her out with contractions so i decided if the baby's heart beat has stop i might as well go in for d n c but yay! my baby was alive and kicking with a hbm of 169 btw when i took a pill i was 8 week 3days and scan showed perfect development ,problem started after 4 days i started having brown spots only when i used to wipe it after peeing unfortunately my gynec was out of town so i called up my home country, my doc over there prescribed me susten 200(natural micronised progesterone) twice a day either by mouth or vagina, can you tell me if it would help and how should i use it, thanks!
BR! Joe
Apr 12, 2012
 I hope it works!
by: Mybz

Well I did get my results back from my blood work. If you recall my progesterone level last week was at a 4. After a week 50mg of progesterone in oil daily my level went up to a 21. I do believe that's a significant increase. But my question is: Is a progesterone level of 21 a safe or good level at 6 weeks 4 days pregnant?
Apr 13, 2012
 Just started Progesterone injections...or so I thought...
by: Wray

Hi there One of the critical factors for me, one which is overlooked completely by prescribers of 17-OHP-C, is because it's a progestin, it's not metabolised into the all important natural metabolites of progesterone. One in particular is allopregnanolone, possibly even more important than progesterone itself. It's a potent analgesic, anti-inflammatory and anxiolytic. See the side effects of 17-hydroxyprogesterone caproate here and here. This is a comprehensive paper Maturitas 46S1 (2003) S7–S16
(Scroll down to the second link on Google to see the full pdf article entitled "Classification and pharmacology of progestins")
I have finally found one 2010 study which used 300mg/day vaginal progesterone, see here. Not 17-OHP-C. There are two forms… 17-OHP and 17-OHP-C. 17-hydroxyprogesterone (17-OHP) is a naturally occurring metabolite of progesterone. Whereas 17-hydroxyprogesterone caproate (17-OHP-C), is a synthetic progestin also used to prevent miscarriages and pre-term births. Often the same term is used for both compounds. No adverse side affects have been reported with the use of 17-OHP, which is produced primarily by the adrenal glands, and increases in the third trimester. But 17-OHP-C I would not recommend, as there are safety concerns about it's use. It doesn't appear to reduce preterm contractions either. I would always favour the use of progesterone though, and let the body metabolise it naturally into 17-OHP. Continued below.
Apr 13, 2012
 Just started Progesterone injections...or so I thought... Part 2
by: Wray

Hi there There is no evidence to date of any adverse side effects to the foetus while using progesterone during Pregnancy and it's more potent that 17-OHP-C, see here, here, here, here, here and here. I'm pleased your doctors thought using 'progesterone' was worth a try, but why use a synthetic when the natural is so readily available and cheap. A further concern of mine is the amount. Injections are usually 50-100mg/dose, I'm not sure how much you've been asked to use, but neither of these is sufficient. The minimum is normally 200mg/day up to 600mg/day if any problems are encountered, ie miscarriages, pre-term births or IVF treatments. Although one woman wrote in saying her doctor wasn't taking any chances and had her on 1600mg/day. Take care Wray
Apr 13, 2012
 progesterone 200 mg
by: Wray

Hi Joe The susten should help, and you've been given a reasonable amount too. Oral progesterone is the least effective Delivery system. Most of it is destroyed in the gut and liver. I would always recommend using progesterone either vaginally or topically. We do have a page on Pregnancy you could look through. Take care Wray
Apr 17, 2012
 injections
by: engineerswife

Hi. I became pregnant at 37. I found out early on that I was pregnant and at about seven weeks began to spot. My OB started me on heparin injections twice daily progesterone injections once daily and a progesterone suppository immediately. I did not find the injections to be too painful and I did them myself. I followed this regimen up until 30 weeks. My son was born 3 1/2 weeks early and perfectly healthy praise God. I never had a miscarriage and can not believe that doctors actually wait for this to happen before starting this treatment.
Apr 17, 2012
 injections
by: Wray

Hi there I do agree with your sentiments. In fact it's not until a woman has had 3 miscarriages that anything is done! I'm delighted your pregnancy went smoothly and you now have a son. Thanks for telling us. You might be interested in reading this story here. too. Take care Wray
Apr 24, 2012
 what do i do
by: broken hearted

I got married in 2008 when I was only 18 to my high school sweetheart we have been trying to get pregnant and every time we do I have a miscarriage I have had 4 and I just don't know what to do the Dr aren't much of a help and I don't know were else to turn plz plz give me some ideas on how to have a safe healthy pregnancy
Apr 25, 2012
 what do i do
by: Wray

Hi there I know having a miscarriage is discouraging, I had five, but it is very common. Something we are not taught in school. We do have a page on Pregnancy you could look through which explains the role progesterone plays and how much to use, plus this one here. Often a drop in progesterone is a cause, a lack of vitamin D too, see here, here and here. Please have a test done. For more info on vitamin D levels, test kits etc see the Vitamin D Council, GrassrootsHealth, Birmingham Hospital and Vitamin D Links websites. Blood levels should be 70-100ng/ml or 175-250nmol/L and not the 30ng/ml or 75nmol/L most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although the latest research indicates it should be 10,000iu's per day, see here.
Jun 26, 2012
 Please Help is progesterone good to get pregnant??
by: anxious!!

Hi there WRAY I hope you can answer my question I am 23 years old 5 4 weighing 133lbs with 2 healthy kids i had no complications getting pregnant or keeping them they were both full term my daughter 5 year old i had c-section cause she was getting strapped with thee omblilical cord i only got to dialte 4cm my 2nd child is a 3 year old boy and he was a repeated c-section. Now i've been trying to go for my 3rd child for the past 2 years and i've had 2 miscarriges... I've been diagnosed with 2 ovarian bilateral cysts 2.5cm and 2.8cm ever since i had my 2nd child, i have a 28 day period cycle i bleed for 5 days on a heavy flow for the 1st 2 days other than that i have no other complications... now my question is I went to my dr.'s and she wants to put me on the progestrone shot will this increse my chances in getting pregnancy how much time it will take? and will i stop taking progesterone as soon as i come out poistive? Please advice me what other steps can be taken for pregnancy thank you
Jun 28, 2012
 Please Help is progesterone good to get pregnant??
by: Wray

Hi there If the miscarriages are caused by a drop in progesterone it will help having the shots. It also depends on what 'progesterone' is used. If the shot contains natural progesterone that's fine. But there are two other forms… 17-OHP and 17-OHP-C. 17-hydroxyprogesterone (17-OHP) is a naturally occurring metabolite of progesterone. Whereas 17-hydroxyprogesterone caproate (17-OHP-C), is a synthetic progestin also used to prevent miscarriages and pre-term births. Often the same term is used for both compounds. No adverse side affects have been reported with the use of 17-OHP, which is produced primarily by the adrenal glands, and increases in the third trimester. But 17-OHP-C I would not recommend, as there are safety concerns about it's use. It doesn't appear to reduce preterm contractions either. I would always favour the use of progesterone though, and let the body metabolise it naturally into 17-OHP. There is no evidence to date of any adverse side effects to the foetus while using progesterone during pregnancy, and it's more potent that 17-OHP-C, see here, here, here, here, here and here. One of the critical factors for me, one which is overlooked completely by prescribers of 17-OHP-C, is because it's a progestin, it's not metabolised into the all important natural metabolites of progesterone. One in particular is allopregnanolone, possibly even more important than progesterone itself. See the side effects of 17-hydroxyprogesterone caproate here and here. Continued below.
Jun 28, 2012
 Please Help is progesterone good to get pregnant?? Part 2
by: Wray

Hi there I always advise starting the progesterone before Pregnancy. Please read through this page for more info. A lack of vitamin D is also implicated in miscarriages, please have a test done. For more info on vitamin D levels, test kits etc see the Vitamin D Council, GrassrootsHealth, Birmingham Hospital and Vitamin D Links websites. Blood levels should be 70-100ng/ml (175-250nmol/L) and not the 30ng/ml (75nmol/L) most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although the latest research indicates it should be 10,000iu's per day, see here.
Jul 05, 2012
 Trying to make the right decision..
by: Celina

Aloha! In 2009 I was pregnant with my dtr. Throughout the entire pregnancy I had bleeding and cramping but was repeatedly told I was fine. My dtr was delivered by c-section at 29wks as I was 4cm dilated and fully effaced. My dtr stayed in the NICU for 6wks, continues to be on therapy, but is otherwise healthy and developmentally on track.

I'm currently 13wks pregnant and the perinatologist wants to start me on
Hydroxyprogesterone caproate 250mg injections at 15wks. I'm a bit hesistant as I am having no bleeding or cramps with this pregnancy and have read that there is an increase miscarriage and stillborn.

Any thoughts???
Jul 06, 2012
 Trying to make the right decision..
by: Wray

Hi Celina Yes plenty! Please don't get the OHP-C injections. There are two forms… 17-OHP and 17-OHP-C. 17-hydroxyprogesterone (17-OHP) is a naturally occurring metabolite of progesterone. Whereas 17-hydroxyprogesterone caproate (17-OHP-C), is a synthetic progestin also used to prevent miscarriages and pre-term births. Often the same term is used for both compounds. No adverse side affects have been reported with the use of 17-OHP, which is produced primarily by the adrenal glands, and increases in the third trimester. But 17-OHP-C I would not recommend, as there are safety concerns about it's use. It doesn't appear to reduce preterm contractions either. I would always favour the use of progesterone though, and let the body metabolise it naturally into 17-OHP. There is no evidence to date of any adverse side effects to the foetus while using progesterone during Pregnancy, and it's more potent that 17-OHP-C, see here, here, here, here, here and here. One of the critical factors for me, one which is overlooked completely by prescribers of 17-OHP-C, is because it's a progestin, it's not metabolised into the all important natural metabolites of progesterone. One in particular is allopregnanolone, possibly even more important than progesterone itself. See the side effects of 17-hydroxyprogesterone caproate here and here. As everything seems to be going naturally I wouldn't use anything. But if at any time you get bleeding, cramping or high blood pressure, please use progesterone instead. I've given you the link to our pregnancy page above, please look through it. Take care Wray
Jul 13, 2012
 Stop progesterone?
by: Jill

I am hoping someone could help me. I am 9 1/2 weeks pregnant and I have been taking the Profesterone in Oil since before I was even confirmed I was pregnant. The reason I am doing the PIO is because I had 2 prior miscarriages on the Crinone and my progesterone was extremely low. I decided to get aggressive and try the PIO, and my progesterone has been great. I have been closely monitored because I have been seeing fertility doctors. I was just told by the nurse to stop the injections at 10 weeks, but I REALLY dont feel comfortable doing so. My body just doesnt naturally make progesterone and I am nervous they are just looking at me like a normal case, but I think I am different. Has anyone been in my shoes?? If so, how did it work out? Thanks!
Jul 14, 2012
 Stop progesterone?
by: Wray

Hi Jill If you were using the Crinone only once a day as suggested, it would not be sufficient. The normal application only contains 90mg progesterone. Miscarriages normally require anything from 200-600mg/day. You say you are taking the progesterone in oil, oral progesterone is the least effective Delivery system so I'm surprised it's helped you. But then you go on to say you don't want to stop the injections, what are they? Are they possibly the progesterone in oil you say you are 'taking'? If any miscarriage has occurred it's always advisable to continue using progesterone until at least the 3rd month, if not the fourth, before considering stopping. It should never be stopped cold turkey either, this can cause a miscarriage. It should always be reduced slowly. It is safe to continue using it till term. We have more info about this on our Pregnancy page. If the doctor won't continue prescribing the progesterone in oil, you can safely switch to a cream. Take care Wray
Jul 14, 2012
 Trying to make the right decision
by: Celina

Aloha Wray! Just wanted to say much mahalo for replying to my inquiry. Your input has been valuable in my decision...but all 3 of my doctors and hubby really wants me to take the injections. If it was soley up to me, I wouldn't. Please keep me in your thoughts for a safe and healthy full term pregnancy!
Jul 16, 2012
 Trying to make the right decision..
by: Wray

Hi Celina I can only say I'm hugely dismayed! Progesterone injections are fine, but not the 17-OHP-C. But the decision is yours, and I can only hope all will be fine. Take care Wray
Jul 24, 2012
 Time to stop progesterone
by: Anonymous

Hi Wray, i have been taking progesterone since i was pregnant, i am 14 weeks gone and the doc says it is time to stop. do you know why?
Jul 25, 2012
 Time to stop progesteron
by: Wray

Hi there Yes, it's because by the 3rd month placental production of progesterone is generally regarded as sufficient. Even if it is I would never advise stopping cold turkey, it's far better to reduce slowly. A sharp drop in progesterone can cause a miscarriage, particularly if they've been previously experienced. We do have more info on our Pregnancy page. Take care Wray
Jul 31, 2012
 Hydroprogesterone Caproate Injections
by: Grieving Mom

I regret not finding this site sooner. I had a still born baby 07/28.I was 19weeks and 5 days. This was my 7th pregnancy and I am 37 years old. I have 2 girls had 3 miscarriages 1 preterm (24weeks old) and now 1 still birth.I went to the Dr. week 17 and was told I was having a healthy little girl. Week 18 I had received 2 injections of hydroprogesterone caproate. Week 19 I was told my baby was dead. The Dr. shruggs his shoulder and says, "I dont know what happened?" I have an incompentent cervic. So I was advised to receive a stitch (cerclage) which I had with both of my daughters. Although this go around the "High Risk Specialist" wants to also add injections of HPC. He says "The data says it's harmless and will prevent preterm labor". I should of stuck to what I had known to work best. I trusted my doctor. He is a chief of the obgyn dept of the hospital a 40year vet. My heart is broken in pieces. Please be advised injections of hydroprogesterone caproate is lethal. I cant bring back my baby girl although if I can help someone else....thats a blessing in itself. Great site!
Jul 31, 2012
 Hydroprogesterone Caproate Injections
by: Wray

Hi there I'm so sorry to hear about this. I don't believe HPC should be used, but more to the point if there is a risk of miscarriage or pre-term birth, use progesterone. After all that's what the body makes naturally to ensure the child is not aborted. It has so many other effects, that no synthetic could possibly do, as they are not metabolised in the same way. Impossible to go into here, but one important fact it affects gene transcription and hence development of the child. Thanks for the kind words. Take care Wray
Oct 10, 2012
 Possible after effects of 17P?
by: Anonymous

I recieved 17-hydroxyprogesterone caproate injections to prevent pre-term labor at the suggestion of my dr. Didn't experience any noticible symptoms during pregnancy that I can recall but about 8-10 months after delivering my son I started to notice some unusual symptoms (anxiety, heart palpatations, vision problems,memory problems,etc.) I had hormone test performed and have a severe hormonal imbalance. I don't see much information on effects after pregnancy when hormones are rebalancing or long term effects of these injections. Has anyone else experienced a similar issue?
Oct 13, 2012
 Possible after effects of 17P?
by: Wray

Hi there 17-hydroxyprogesterone (17-OHP) is a naturally occurring metabolite of progesterone. Whereas 17-hydroxyprogesterone caproate (17-OHP-C), is a synthetic progestin also used to prevent miscarriages and pre-term births. I can find no evidence of complications following birth, but there are some risks involved while taking it, see 17-hydroxyprogesterone caproate here and here. One of the critical factors for me, one which is overlooked completely by prescribers of 17-OHP-C, is because it's a progestin, it's not metabolised into the all important natural metabolites of progesterone. One in particular is allopregnanolone, possibly even more important than progesterone itself. I feel therefore your symptoms are post natal depression, they certainly fit. We do have more info on our Pregnancy page. Large amounts of progesterone can help, see here. We also have a page on Anxiety which gives a list of nutrients which can help too. After birth progesterone drops sharply, sending about 25% of women into depression, from the baby blues to post natal psychosis. This drop in progesterone is not accompanied by an equivalent drop in oestrogen, which leaves the woman with Oestrogen Dominance. Oestrogen causes, amongst many other things, water retention, memory problems and heart palpitations. The oedema causes the focus of the eyes to change, progesterone can help, it's an excellent diuretic, see our page on Traumatic Brain Injury. Oestrogen also increases the risk for dementia, see here.
Continued below.
Oct 13, 2012
 Possible after effects of 17P? Part 2
by: Wray

Hi there Finally oestrogen causes prolongation of the QT interval, which results in palpitations, arrhythmia and Torsades de Pointes. Whereas progesterone shortens the QT interval, see here, here, here, here, here, here and here. If you should wish to try progesterone, I recommend 100-200mg/day, any less I've found often exacerbates symptoms. We have more info on our page How to use progesterone cream. Take care Wray
Oct 26, 2012
 Is benzyl alcohol progesterone shots bad for my pregnancy??
by: Desire to be a Mom

Hi...

Been through many miscarriages in the past. I understand how you guys feel. It does HURT! We share our feelings together which is a good thing.

I am going through IVF really soon in November 2012. I am so scared to try those medicines that my doctor gave me. I researched everything online. As far as I know that Preservative free heparin or Preservative free Enoxaparin Sodium Injection is more safe for the pregnancy or even fetus. BUT...is progesterone shot with benzyl alcohol bad also??? I mean I have to take progesterone to maintain my pregnancy in November. What is the best alternative ? Any idea that I could try new method of getting natural progesterone (orally or vaginally or shot) Whats more? my progesterone cream has parabens! I know it is very bad! I wouldn't use it at all.. I need to know which progesterone cream (vaginally) is safest (of course without parabens and sodium laureth salfate...

Please help me with the right information and the right medicines I really need for my IVF.


Thank you so much!
Oct 26, 2012
 Is benzyl alcohol progesterone shots bad for my pregnancy??
by: Wray

Hi there I don't understand why you need the heparin, do you form clots easily? I can also never understand why any doctor would give progesterone shots after IVF. Why not suppositories as so many clinics use. The cream is just as effective too. Shots only contain 50mg progesterone, plus they have preservatives I wouldn't use on or in my body. Some use peanut oil to which many have allergies, some sesame oil. We do have a page on Delivery systems with more info. Amounts varying from 200-600mg/day are normally given for recurrent miscarriages, why such a little dose for IVF. Suppositories and creams are painless, injections are not. If interested in a safe cream, please look at our page here. It gives a list of ingredients. We also have a page on Pregnancy you might like to look through. Why do you need IVF? Are you not ovulating? Or if you are, are you not retaining the embryo? Please let me know, as often progesterone and vitamin D can help. I'm currently helping a girl who's been trying to fall pregnant for 2 years, with some help from progesterone and vitamin D, she's now 7 weeks pregnant, and has just heard the heart beat. Both these are vital for ovulation, conception and the growth of the foetus, in particular it's brain, leading to a successful pregnancy. Vitamin D is vital for breast feeding too, please have a test done. It could be your level is too low. And please watch the videos on vitamin D at the end of the pregnancy page. Another nutrient vital for the foetus is taurine, see here, here, here, here, here and here. Continued below.
Oct 26, 2012
 Is benzyl alcohol progesterone shots bad for my pregnancy?? Part 2
by: Wray

Hi there For more info on vitamin D levels, test kits etc see the Vitamin D Council, GrassrootsHealth and Birmingham Hospital. Blood levels should be 70-100ng/ml (175-250nmol/L) and not the 30ng/ml (75nmol/L) most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although recent research indicates it should be 10,000iu's per day, see here. Take care Wray
May 22, 2013
 2nd Pregnancy
by: Anonymous

My wife is pregnant with our second child and our new OB has highly suggested that we think about getting progesterone injections for this pregnancy. Our first baby girl was delivered at 35.5 weeks, so she was only a half week from being full term. But we think it's because of all the activities that my wife was doing that day prior to her water breaking. We had gone with the summer school kids biking in the morning for about 2 hours, and she was mostly on a 3 wheel bike where you're laying back similar to the position of giving birth. Then we had taken the kids from church to a VBS camp that same day in the afternoon. After setting up the tents, preparing & having dinner, hanging out, and getting everybody ready for bed, her water broke in the tent after using the restroom. It wasn't leaking too much as we had time to drive back 45 minutes to the hospital and deliver our baby girl the next morning at 10:00am. She was small at 3 pounds and 14 ounches, so she had to stay in the NICU for 9 days. They allowed us to take her home even though she was still 3 pounds and 14 ounches. We're not sure about taking the prgesterone injections for this 2nd pregnancy. Do you think we need it?
May 25, 2013
 2nd Pregnancy
by: Wray

Hi there You say your wife delivered at 35.5 weeks, or half a week off full term. But full term from the date of conception is 38 weeks. Any date before 37 weeks is regarded as pre-term, did the doctors not mention this? I believe your wife's hectic activities were undoubtedly the cause of labour starting. Any stress, good or bad, can cause a miscarriage or pre-term birth. She presumably had no problems during the Pregnancy? Stress drops progesterone levels, and a number of other nutrients too, although they would not affect labour. One of the many roles progesterone plays in pregnancy is to keep the uterus quiet. It prevents the rise of the inflammatory cytokines, chemokines, prostaglandins and oestrogen which all play a part in labour which is an inflammatory process, see here, here and here. It could be your doctors thought the pregnancy pre-term which is why they are suggesting progesterone injections. Please be aware there are natural and synthetic injections, they are also painful I believe and only deliver 50mg progesterone. Many women with miscarriages and pre-term births are treated with amounts ranging from 200-600mg/day. They are papers about this on our pregnancy page above. There are two forms of injections… 17-OHP and 17-OHP-C. 17-hydroxyprogesterone (17-OHP) is a naturally occurring metabolite of progesterone. Whereas 17-hydroxyprogesterone caproate (17-OHP-C), is a synthetic progestin also used to prevent miscarriages and pre-term births. Often the same term is used for both compounds. No adverse side affects have been reported with the use of 17-OHP, which is produced primarily by the adrenal glands, and increases in the third trimester. But 17-OHP-C I would not recommend, as there are safety concerns about it's use. It doesn't appear to reduce preterm contractions either. Continued below
May 25, 2013
 2nd Pregnancy Part 2
by: Wray

Hi there I would always favour the use of progesterone though, and let the body metabolise it naturally into 17-OHP. There is no evidence to date of any adverse side effects to the foetus while using progesterone during pregnancy and it's more potent that 17-OHP-C, see here, here, here, here, here and here. One of the critical factors for me, one which is overlooked completely by prescribers of 17-OHP-C, is because it's a progestin, it's not metabolised into the all important natural metabolites of progesterone. One in particular is allopregnanolone, possibly even more important than progesterone itself. See the side effects of 17-hydroxyprogesterone caproate here and here. Take care Wray
Feb 18, 2014
 p17
by: cassie

In 2010 I had a miscarrage at 12 weeks in 2011 I had a full term baby I have a bicornat uterus so I needed a c section she was breech in 2012 I had a stillbirth at 23weeks I am currently 8 weeks 4days pg and my first apt is tomorrow and my dr only does the p17 suppositories but the dr who did my c section is a high risk dr and does the shots so im thinking of switching drs but isn't 15 weeks a little late to start the shots???
Oct 01, 2014
 response to Wray
by: Linda Newgent RN

17P injections are for women with a history of spontaneous preterm birth of one baby (not multiples) and progestogen vaginal gel has found utility in women without this history who have a shortening cervix. They are NOT interchangable!!(ACOG/SMFM guidance). Though the manufactured version of 17P may have a preservative(in a 5 dose vial, by the way, not unit dose),compounded versions may be preservative free and available as unit dose. The recommend weekly dose is 250 mg 17P in 1ml caster oil (sesame oil was not used in the groundbreaking Meis trial and has NOT been tested.) Other doses are being looked at but no conclusions have been published that recommend higher doses for reducing the risk of preterm birth.
Oct 01, 2014
 is 17P dangerous?
by: Linda Newgent RN

Without knowing exactly the medications your mom was given I cant be difinitive, but from 1938-1971 there were a large contingent of women receiving DES (Diethylstilbestrol)thought to prevent miscarriage and preterm birth. Some of the daughters of these women had problems with their reproductive anatomy, including mischaped uteri. This was addressed in 71 by the FDA. 17P, on the other hand has maternal/fetal safety documented going back to 1936 (Mayo study) and studies continue to reflect that safety profile including the NIH.(National Institute of Health). Though caution is good in assessing ANY medicines for ANYONE, it would be a shame to dismiss the benefit of 17P reducing the risk of preterm birth by 34% in women with a history of preterm birth because of misunderstanding the safety profile.
Oct 08, 2014
 P17 shots
by: Rochi

Hi I had my second p17 shot last Monday and I had a reaction I felt my chest thigh and shortness of breath I could also hear wheezes when taking a deep breath I talk to the doctor and she doesn't think is due to the progesterone. I went to the ER and they couldn't find anything wrong. After a few days it went away but I am scare of getting my third shot and have the same feeling again! Please help
Oct 12, 2014
 Injections
by: Anonymous

I didn't understand the reasoning behind waiting till 16wks to start my injections.So, I got a second opinion and discussed it with the consultant my health insurance provides. 90% if miscarriages before 15wks are due from nonstoppable conditions. I do have breathing problems with these injections.
Apr 01, 2015
 is it to late
by: Tasha

I am 37 and I've had 4 still births and 3 miscarriages and my 17 r.old was born at 5 in a half months but my 3yr.old was born full term with the shot and I had my 1st shot 6yrs ago I had a miscarriage with her, I'm now 21 weeks pregnant and my doctor said I should get the shot but I haven't yet is is to late to get it?
May 26, 2015
 Is it too late?
by: Mommarue

I am 42, and am 7 was pregnant. Three days ago my progesterone level was 5.45. Down from 13 at prepregnancy. I started bleeding, light a light period two days ago. I upped my progesterone cream. The bleeding is off and on, only when I wipe. I can't get suppositories here in Ukraine, but I can get shots, and I can get something called Lutein, which is a progesterone tablet that can be inserted vaginally. Is it too late for this to help? I'm flat on my back, feet up. Drinking vitamin C, and freaking out. Any help?
May 26, 2015
 Is it too late?
by: Wray

Hi Mommarue We do have a page on Pregnancy you could look through, and another here. I would suggest increasing your progesterone to 400mg/day, divided into two or three applications. I can't find any info about Lutein progesterone, so can't advise on it. The shots, if progesterone, can help. But they are generally only 50mg which is not great. Take care Wray
Aug 30, 2015
 Miscarriage/irregular circle
by: Anonymous

I am a 28 year old lady,who had miscarriages twice in October2013 and March 2014 respectively after which I haven't been able to conceive and my period irregular.I was told to take progesterone 100mg in may and I saw my period and it ceased again.I repeated the same progesterone last week and nothing yet.My HCG is 3.59.I just wish to know wats going on as I have never had a baby of my own.
Dec 10, 2015
 Progesterone enlarge buttock
by: Javid

If some girls has small breast and buttocks, in this regard can we use injection progesterone for enlargement of breast and buttocks? Here I want your respected opinion in this regard.

Thanks
Jan 31, 2016
 Progesterone injections n the '70's
by: Anonymous

Hi there Wray, I have been diagnosed with Endometriosis and Adenomyosis and am 43. I had to have Uterine Ablation ladt year because I was flooding so much I needed IV Feritin every year for the last 5 years. My Gyni knowing that the pharmaceutical drugs cause me to have severe depression told me he was happy for me to try your cream which I did. 6 months later I am in a lot of pain with fluid behind my uterus, bleeding again and facing hysterectomy. I was using about 5 ml twice a day. Maybe this dose was too low?

Also my mother had several miscarriages due to no progesterone. She kept me by agreeing to 7 months in hospital and progesterone injections. I wonder if this could have caused all my problems. I'm so distressed right now and worried about cancer risk with this 70's drug. 😪😪. Also if this may have an affect down the line on my two boys.

Thanks for taking the time to read this.
Feb 05, 2016
 17-Hydroxyprogesterone
by: Doug and Leslie

My wife's doctor has recommended 17-Hydroxyprogesterone beginning the 16th week of her pregnancy. She is at 12 weeks now.

Her background. She has a bicornuate uterus and at first difficulty becoming pregnant. After several years of different treatments we gave up and try some home remedies. Her first pregnancy she miscarried at 16 weeks. The second one our bad was born, 2 lbs at 30 weeks and spent 3 months in 2 different NICU's but is healthy 3 year old now. Third pregnancy another miscarriage at 16 weeks.

This is her forth pregnancy. My thoughts are the bicornuate uterus may be her problem. Do you think 17-hydroxyprogesterone is something we should consider?
Feb 05, 2016
 Progesterone shots after late miscarriage
by: Anonymous

I went into labor, my water broke, and I miscarried at 15.5 weeks. Doctors felt it was likely some kind of infection because placenta showed inflammation and the baby was otherwise healthy and had a heartbeat up until the end. Possibly had food poisoning a month prior. I am now 15 weeks pregnant again. This pregnancy has been much easier than last time as last time I had extreme pelvic and back pain from the start, as well as gallbladder attacks. Had my gallbladder removed since then. They want to put me on synthetic progesterone shots starting at 16 weeks. Is it necessary or is there an alternate treatment that would help? I recently felt some aching in my uterus which I experienced last time before the miscarriage. Not sure if it's normal at this stage or mild contractions. Thanks
Feb 18, 2016
 progesterone injections
by: Anonymous

I had my son at 32 weeks in 2008. He had to spend 4 weeks in hospital before he could come home but the doctors could find no reason that I should have had him early except maybe high stress. Since then I found out pretrem labor has affected the last three (myself included) generations on my father's side. I have had three more children now and been put on progesterone for all three. All three had been delivered after 37 weeks healthy and able to come home from the hospital with me. My injections were started at 16 weeks. Also the doctor says its a coinsedince but I delivered all three exactly three weeks after stopping the injections.
Mar 31, 2016
 projesterone and fibroid
by: Patience

Hi, I have been married for 2 years and suffered 2 miscarriages due to hormonal imballance weak cervix according to doctors. Now I am about 9weeks pregnant and after the scan they discovered a 66mm fibroid coexisting with the foetus, the gyno placed me on weekly projesterone injection which I started on 28 march but to my surprise after my first shot I could not sleep that night, so much pain in my pelvic region and lower abdomen to by back, I was in tears all night, returned to the doctor the following morning and he stopped the shot saying it was the fibroid and then administered pain killers.
I have made research and articles like this and would like to know what to do.... Will my pregnancy sustain? Is this pain going to subside soon cos for 2 nights I cannot sleep due to internal pain.
Please advice me because I'm worried I had 2 miscarriages in the first trimester.

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