Progesterone cream or trouche

Hello, I was just wondering what was better progesterone cream or trouches. I have both 20 mg trouch told to take once a day and I also have natural cream told to take one squirt a day = 25 mg. I am not sure which one to do?


Comments for Progesterone cream or trouche

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Dec 29, 2007
Cream or troche
by: Wray

Hi there I'm not in favour of taking progesterone orally, as 90% is destroyed as it passes through the gut and liver. So if you swallowed your troche, the 20mg/day would translate into 2mg/day.

The body is not designed to absorb hormones via the digestive track, after all they are made endogenously. The best methods of absorption are via intra-muscular injections (painful!), transdermal creams, via the buccal cavity and vaginal or rectal pessaries/suppositories.

If though you treat the troche as it should be used and hold it in your mouth until it has dissolved, you would then absorb the progesterone affectively, but it's so bitter, I wish you luck!

Finally the dose you've been given is to my mind far too low. All the successful studies done using progesterone have used between 100-200mg/day, some going as high as 400-600mg/day. Hope this helps. Take care Wray

Mar 05, 2009
Troches - some still passes through the liver
by: Elizabeth

I take an estrogen and a progesterone troche each day (separately). Troches are convenient, but I've found there's a residual amount of each one left in my mouth after they're supposedly "dissolved." When I asked the compounding pharmacist what to do, he said to swish any remainder of the troches with water and swallow. Obviously, whatever is swallowed gets routed through the liver. And I couldn't help but wonder the following:

1- Was the residual material the progesterone, or the inactive ingredients used to make the troche?
2- What are the inactive ingredients - are they healthy to ingest? (The compounding pharmacist said they're similar to, but not the same as, parabens, and parabens are known to cause cancer)
3- What is the impact on your teeth and gums over time?
4- Since progesterone can supposedly convert to estrogen as needed in the body, could dissolving progesterone (or estrogen) in a troche form in the mouth put you at greater risk of oral cancer (since excess estrogen has been linked to cancer?
5- When I use an estrogen troche, my mouth and throat burn. Why?
If anyone knows the answers to these questions, I'd love to know. Thanks . . . Elizabeth

Apr 04, 2009
Troches - some still passes through the liver
by: Wray

Hi Elizabeth
1- If the progesterone was not fully dissolved before the troche hardened, then it could well be progesterone you are feeling.
2- A troche should not need preservatives, as there is no water in the compound, but it could have been phenoxyethanol. Troches can be made from gelatine or a PEG (polyethylene glycol) based wax.
3- I don't know
4- As you are already taking an oestrogen troche, the risk is there.
5- I have not heard of oestrogen burning either the skin or mouth lining, so it's probably the inactive ingredients, most probably the PEG wax, which in itself can contain dioxane, a known carcinogen. Also occasionally known to cause inflammation of the gums.
6- No study has been done on the absorption of troches, but some authorities put this at about 30-50%. The remaining progesterone being swallowed, subsequently becoming inactivated by the liver.
7- The best delivery systems are injections (painful), vaginal suppositories or gels and transdermal creams. Although the cream is to my mind the far better route, as it can be used where needed. On painful areas, in the vagina for dryness and inflammation, burns (excellent), on the face where it helps with wrinkles and more. Take care, Wray.

Sep 12, 2013
by: Anonymous

I have progesterone that is made of gelaton, I was assure by my pharmacy that this was safe and that it was better than cream, You have to trust and believe what your doctor tells you. I take hormone pellets in my hip that lasts 3 months and the progestone isn't included.... This is new to me.. I will find out how Sussanne Somers takes hers.....Lauren

Oct 07, 2015
by: Dawn

I use the troche am and pm total of 150mg. I let it totally dissolve in between cheek and gums. It takes at least 45 minutes for that to happen. I feel like I'm getting enough of the progesterone but I don't know for sure.
We keep getting mixed messages on whats the best method. It's kind of frustrating. what about using both?

Aug 24, 2016
by: Lisa

I am on Progesterone 150mg Troche which I take 2 hours before bed and yes it dissolves in the corner cheek within 5 mins which I have no problem with however I am also having to rub E21.5MG Oestrogen top click cream on the soft parts of my body like wrist, buttocks after a shower every morning and yes it is helping a lot with the sweats and loss of sleep however the moods are still there with a vengen

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