by Molly
(New York)

Hi there,

I’m hoping you can be of assistance.

I am 6 weeks pregnant and was prescribed oral prometrium 200mg a few days ago, when my progesterone started dropping. I had a recent miscarriage (two months before this pregnancy) and was worried about losing this one.

Since I started taking the oral progesterone I am feeling super nauseas and weak, I’m afraid I’m heading towards hyperemesis gravidarum, like I had in the past. As per my doctor’s recommendation, I started taking the prometrium vaginally. (Interestingly, my serum progesterone levels haven’t gone up since, and I’m on prometrium for over a week now.)

Any suggestions?

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Nov 09, 2022
by: Joy

Hi Molly

As you have most probably read on this website that all forms of oral progesterone is not the best delivery method as around 96% gets destroyed by the gut and liver, see here. Vaginally is far better. A week of use is not really enough time to really notice a difference. What is your Vitamin D3 level? A deficiency reduces the benefits of progesterone, it is also vital for you and your unborn baby.

This usually helps with severe nausea. If the nausea has already started and is severe enough to cause vomiting, then I've found it can take 2 or more months before it's under control using 400mg per day. Or a higher amount such as 800mg per day can shorten the time. But it is trial and error, I wish there was an exact amount and time, but progesterone doesn't work like that. It's entirely dependent on the person using it, their symptoms and how severe they are, their age etc. Give the 400mg per day a week before increasing if it hasn't helped. Please read the Pregnancy page. You might want to discuss this with your doctor.

The page on Miscarriages my also interest you if you have't read this already.

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