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Many health problems and endometriosis

by Veronika
(Czech Republic)

Dear Wray,

please, excuse my English, I´m from the Czech Republic :)

I´m 30 years old.
I´d like to ask you for an advise. 2 years ago I found (by laparoscopy) that I have endometriosis (3. grade, my fallopian tubes are OK, I´d love to have a baby as soon as possible).
Before the laparoscopy I spent 3 years taking antibiotics because of pelvic pain (doctors thought that it was inflammation due to infection - Chlamydia Trachomatis).
But my problems with pelvic pain started when I went off birth-control pills (when I was 25 years old).
Before I started taking birth-control pills, I had problems with my menstruation – at the age of 14 spotting occured and lasted many months. Doctors gave me birth-control pills and for me it was big relief. I was always very, very skinny (173 cm, 46 kg) and I was not able to gain weight (which is strange). In order to increase weight and beat acne I took very strong pills (for example Diane-35). I was really happy, because I finally put on weight a little and I had beautiful skin and hair, I was feeling healthy.
At the age of 25 I decided to have a baby so I went off the pills. Next month I started feeling pain in my abdomen. My period was irregular again. I also found that I have Chlamydia, chronic Lyme disease, cervix precancerosis and PCO. I became very tired and sick.
I also have a lot of problems due to long term use of antibiotics - chronic fatigue syndrom, candida, intersticial cystitis, chronic bacterial vaginosis (E.coli, Enterococcus and chronic Chlamydia). My problems are getting gradually worse. I feel strong pain (endometriosis) every day. I also have autoimmune disease (positive Antinuclear Antibodies – ANA).

Doctors urge me to take birth-control pills or Visanne, but I don´t want syntetic hormones any more (although I was feeling really well on them).
A year ago I ordered Awaking Woman restore balance progesterone cream and I´ve used it from day 16 to day 26 of my cycle. I used only about 10 mg/day and I was feeling better (maybe placebo effect), my periods became regular, I was often ovulating, but I still felt the pain.
A few days ago I found your website and was shocked how much progesterone cream I actually should take daily! I ordered 2 Natpro creams and in the meantime I increased the dose of Awaking Woman progesterone cream to 40 mg daily. Next day something terrible has happend! My lower abdomen is swollen and I feel unbearable pain all day, my breasts are very sore and swollen, I started to have hot flashes, I became very tired and sleepy, I´m depressed, I feel like I have horrible PMS and I feel sudden pain in my thyroid gland. Because of the unbearable pain, I went completely off the cream. Now my pain and other problems still remain, I´m absolutelly scared and I'm afraid that it will stay this way.

I know that you will probably advise me to take much more cream daily (because endometriosis needs 500mg/day), but I´m not sure about that. Before I started taking progesterone cream, my test results from saliva test (ZRT Laboratory) showed that my estradiol is lower than expected range for premenopausal woman (1.0L). That makes sence because I´m very skinny and I always felt vaginal dryness, painful intercourse, memory problems and so on. I only know that I was exposed to xenoestrogens many years (I used vaginal suppositories with parabens daily because of vaginal dryness). My progesterone is within expected range for premenopausal woman (83). Testosterone is within normal range (32) but my symptoms indicate androgen excess (I have acne, PCOS, excessive hair on face, thinning hair on the head and very oily hair and skin). My DHEAS is low.

Can you please advice me something that could help me in my situation? Is it appropriate to use high doses of progesterone cream when I have such low levels of estrogen and I´m so skinny? I reacted so badly on 40 mg/day – I´m scared to death to take more, I feel terrible abdomen pain now. I´d also like to have a baby – I´m finally ovulating and don´t want to disturb my menstruation cycle. I also have a serious problem with chronic bacterial vaginosis – I tried all of the available vaginal suppositories with only temporary relief. The only thing that still helps me are garlic suppositories – unfortunately I read that garlic has estrogenic activity! Is it true? And would you advise me to use the cream in the vagina when I have bacterial vaginosis?

I greatly appreciate your feedback. Thank you in advance.

Veronika

Comments for Many health problems and endometriosis

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Jun 26, 2013
 Many health problems and endometriosis
by: Wray

Hi Veronika Well your English is amazing! The Contraceptives would have helped you, as it suppresses the ovaries. So lower amounts of testosterone and oestrogen would be produced, but of course they stop ovulation, so no progesterone is secreted. I can understand your reluctance to start them again. And you are right, I have found 500mg/day progesterone is needed if pain is felt with Endometriosis. I see you must have read the page. We also have one on PCOS too. By the way, memory problems are caused by oestrogen, it increases dementia, progesterone prevents this, see our page on HRT for more info. Unfortunately increasing to 40mg/day progesterone would have made you worse, as it will stimulate oestrogen. The symptoms you describe are all Oestrogen Dominance symptoms. Which you do have anyway, your ratio is only 83:1, in spite of low oestrogen levels. You might like to see our page on Saliva Tests, you'll notice the ratios are 600:1 and over. Your testosterone is within range, but the total testosterone is meaningless. It's the free testosterone which tells the story, and it appears yours must be high. It's only the free which is active. If bound to SHBG (sex hormone binding globulin) testosterone becomes inactive, progesterone raises levels of SHBG, see here, so preventing it's rise. High testosterone initiates Acne, see here. SHBG drops if sugars are eaten, even those found in all grains, legumes, processed milk and sweet starchy fruits and vegetables. Fructose, sucrose and glucose, reduce SHBG by 80, 50 and 40% respectively, see here. Thereby allowing testosterone to rise. It's best to avoid all the foods and sugars mentioned. Wine and beers contain carbs, so it's best to avoid those too. Plus alcohol affects hormone levels in women, see here and here. Continued below
Jun 26, 2013
 Many health problems and endometriosis Part 2
by: Wray

Hi Veronika It decreases progesterone levels and increases androgen levels, both the total testosterone and free testosterone become higher. Sugars and large meals also drop progesterone levels, see here. Plus insulin drops levels too, see here. This means SHBG also drops, testosterone rises, another vicious cycle. Chronic bacterial vaginosis is usually found in premenopausal women or women on oestrogen replacement therapy. It's associated with a number of symptoms, one is peripheral neuropathy. Progesterone is known to regenerate nerves, see here. Another is Candida, progesterone reverses the inflammatory oestrogen response, see here. Mast cells are also implicated, progesterone has an inhibitory affect, see here. Whereas oestrogen stimulates mast cell secretions. Significantly higher levels of TNF-alpha are found in women with chronic bacterial vaginosis, progesterone inhibits TNF-alpha, see here and here. I do advise using the cream in the vagina, I do every night. Many women use it for dryness, it's also an anti-inflammatory too. In the USA 61% of chronic pain patients are women, starting at menarche and decreasing at menopause. In some cases symptoms of chronic bacterial vaginosis increase at mid-cycle and at menses, when the oestrogen to progesterone ratio is high. Interestingly complaints of vulval pain are becoming more common. Could this be due to the increasingly prevalent low vitamin D levels most of us have? This is a potent anti-inflammatory. Continued below
Jun 26, 2013
 Many health problems and endometriosis Part 3
by: Wray

Hi Veronika Please have a vitamin D test done, I suspect yours is low. You have so many infections, which is often a sign. And all 'autoimmune' diseases have low vitamin D levels. Many have high oestrogen and low progesterone too. Please consider taking high doses of antioxidants, you need to reverse the oxidative stress you have, the PCOS and endo are both caused by it. Plus the host of other pathogens you have. There is a list of antioxidants on the PCOS page, please don't get capsules from a health shop, powders are better, not only cheaper but you can adjust the dose to far higher. You do need progesterone, but I'll have to leave that to you to decide if you use it or not. Take care Wray
Jun 26, 2013
 recommended dose of progesterone cream
by: Veronika

Hi Wray, thank you very much for your response. I´ve decided to try high doses of progesterone. I´ll use it every day for 6 months or more… Then I´ll try to restart a cycle by using the cream on a cyclic basis (I´d like to conceive).
Please, what would you recommend in my case - should I gradually increase the dosage or start using 500mg/day from the beginning? Will I stop bleeding with this high dose? I think that a few months without menstruation could help me with my problems.
I´ll also try to take many antioxidants and have a vitamin D test done. I have allergic reaction to the sun (rash), so I've unfortunately always avoided the sun. Now it makes much more sense to me.
Thank you very much for your help.
Jun 27, 2013
 recommended dose of progesterone cream - part 2
by: Veronika

Hi Wray,
I have a few more questions for you and I´d be very grateful if you could tell me your opinion on these.
1) I´ve done some „research“ and found that natural progesterone can be converted into estrogen if our estrogen is low as the body senses that it needs more estrogen. Apparently, the progestins, since they aren't recognized by the body as progesterone, don't do this. This worries me as I certainly don't want to feel more pain (I feel unbearable pain since I increased dose of progesterone cream). Many women taking Visanne reported pain relief, although they experience some side effects of the drug. I think they don´t feel as much oestrogen dominance symptoms as women on natural progesterone cream. I know that you advise women with endometriosis to use higher dose (500 mg or even more), but what if it will cause another problems? I also found that progesterone has a sedative effect, and at high doses, it can act as a strong tranquilizer... and that taking that high of a dose for an extended period of time would cause "progesterone dominance". Is it true? I´m asking because I´m so scared that my pain will be even much worse on higher doses of progesterone cream (or I´ll have to suffer many months on high doses of Natpro with the hope that maybe it will be better in future in case I´ll keep waiting)... I´m considering taking Visanne for the first months (which should theoretically help manage the pain) and then move to Natpro (I´ve ordered many Napro creams) - maybe I would better tolerate Natpro then? What do you think about that?
From your experience with Natpro and women with endometriosis - was Natpro helpful for all of them (in high doses)? Or Visanne could be more effective in case of acute pain?
2) How would you recommend to support thyroid function (I have hypofunction of thyroid gland)? Do you recommend for example Iodoral or Lugol's Solution?
3) Can I take progesterone together with Indole-3-carbinol or DIM?
Thank you very much for your response! I really appreciate your work and your information.
Veronika
Jun 28, 2013
 recommended dose of progesterone cream
by: Wray

Hi Veronika I'm pleased about your decision, it's one only the individual can make. I can't force anyone too, or wouldn't even want to. I am always aware of the cost of high amounts too. I've found gradually increasing the amount will only make Oestrogen Dominance worse, as each small rise in progesterone will stimulate oestrogen. It's best to go high all at once. You should stop bleeding with 500mg/day, but only using it will tell. Some have found 400mg/day does, some need much higher. I'm so interested you get a rash in the sun, the lower the vitamin D the less protection you have from the sun. So it's a catch 22 situation, you need the sun for vitamin D production, but can't tolerate it to make it! So supplements are the answer, you'll find once your level is high you will be able to go in the sun again. And you'll find the progesterone more effective too. Let me know how you get on. Take care Wray
Jun 29, 2013
 recommended dose of progesterone cream
by: Wray

Hi Veronika There are three main groups of steroids.... mineralocorticoids, glucocorticoids and androgens. The three oestrogens are all converted from testosterone by the enzyme aromatase.

Mineralocorticoids…..
Cholesterol → Pregnenolone → Progesterone → Corticosterone → Aldosterone

Glucocorticoids…
Cholesterol → Pregnenolone → Progesterone → 17-OH-Progesterone → 11-Deoxycortisol → Cortisol → Cortisone

Androgens…..
Cholesterol → Pregnenolone → Progesterone → 17-OH-Progesterone → Androstenedione → Adrenosterone → two further hormones
Cholesterol → Pregnenolone → Progesterone → 17-OH-Progesterone → Androstenedione → Testosterone → DHT
Cholesterol → Pregnenolone → 17-OH-Pregnenolone → DHEA → Androstenediol → Testosterone → DHT
Cholesterol → Pregnenolone → Progesterone → 17-OH-Progesterone → Androstenedione → Testosterone → Oestrone ⇄ Oestradiol → Oestriol (also Oestrone → Oestriol)

Cholesterol → Pregnenolone → Progesterone → 17-OH-Progesterone → Androstenedione → Testosterone → Oestrone ⇄ Oestradiol → Oestriol (also Oestrone → Oestriol)

Genova Diagnostics has a very comprehensive chart. There's a feedback loop between them all. So if the body senses any one of the above falling it will produce more. Which also means the opposing hormone will drop, it's an endless cycle. Or should be, but there are certain points in a woman's life when things can go awry. Puberty, PMS, after giving birth, Peri-menopause and Menopause. Continued below
Jun 29, 2013
 recommended dose of progesterone cream Part 2
by: Wray

Hi Veronika During each of these excess oestrogen can be produced, or low progesterone can be experienced. Some women also experience a defective luteal phase, when the corpus luteum produces too little progesterone, so symptoms of Oestrogen Dominance can be felt. Stress causes ovulation to fail, which means no progesterone is produced. Stress makes endo worse. It's an inflammatory disorder so high amounts of antioxidants are needed to reverse it, not only progesterone. Progesterone does have a sedative affect, hence it's benefit when anxious, it's a potent anxiolytic. It can be used as an anaesthetic too. None of the women using high amounts have ever complained about this, and some have gone well over 1000mg/day for a year or more, see here, here here and here. Progesterone levels should always be higher than oestrogen, all over this site I tell women to use enough to make progesterone dominant. Labs give a range of ratios of P:E2 from 100:1 to 500:1, I have yet to see a well women with a ratio of 100:1. If you look at the results of our Saliva Tests they are all over 600:1. Progesterone must be dominant. I have no experience of Visane and endo so can't advise you on that. But it is a progestin, or synthetic progesterone, which does stop ovulation, and therefore all ovarian progesterone production. We have more info on our Contraceptives page. Continued below
Jun 29, 2013
 recommended dose of progesterone cream Part 3
by: Wray

Hi Veronika Vitamin D is essential for the thyroid, see here, here, here, here, here and here. So too are tyrosine, iodine and selenium, all three of these make up the two thyroid hormones, T3 and T4. I believe nascent iodine is meant to be better then the ones you've mentioned. Although this comment came through from someone who did use Iodoral, see here. I have often suggested DIM and calcium D-glucarate to reduce oestrogen or make it less potent, milk thistle helps too. But you need to take very high doses of antioxidants, you'll be rattling if you take those too. Take care Wray
Aug 08, 2013
 problems with Natpro
by: Veronika

Dear Wray,
again - I´m sorry for my English...

I have a terrible time with Natpro. I´m using about 1500 Natpro/day for 3 weeks and my endo-pain is absolutely unbearable, I´m so tired that I must sleep all day, I´m sweating all the time and I have all the symptoms of estrogen dominance. I have had blood hormone test done and I´m shocked! My Estradiol is 3565 pmol - before Natpro it was only about 100. Progestrone is only 1,1 ! I´m absolutely disappointed and I´m afraid to use Natpro further. Can you please advise me what to do? Should I use Natpro, wait and hope that it will be better in the next weeks/months? I´m afraid (because of the pain and blood test) that my endometriosis got much worse that it was before Natpro. And I´m afraid of cancer because I have a precancerosis on my cervix. I can´t go to work because of the endo-pain and fatigue... and the high doses of Napro are very costly for me. I will continue to use Natpro when you tell me that this reaction is normal and that I must wait and see. But I´m very sad about the results so far.

P.S. I´m taking all the antioxidants you mentioned, in high doses (in fact, I use them for several years), vitamin D in high dose (and I´m sunbathing every day), I also take Calcium D-Glucarate, DIM and so on. But nothing has helped...

I greatly appreciate your advise. Thank you in advance.

Veronika
Aug 09, 2013
 problems with Natpro
by: Wray

Hi Veronika I'm so sorry this has occurred, and I'm sad too. It can stimulate oestrogen and evidently with you it has gone very high. You might like to see this page here. They did a study on cancer and found progesterone reduces the tumour because it inhibits mitosis. But they also found if too little was used it caused the reverse, because oestrogen increased. I know you are using a very high amount, but not as high as the study above. I'm reluctant for you to go higher because of cost, it's such a drawback this. Have you had a vitamin D test done, do you know your level? It could be it's still low in spite of the high dose you take. You have huge Inflammation in your body, and I've found this uses up the vitamin D and the level does not rise. You say you're taking high doses of the antioxidants I mentioned, but I see I gave you none. Unless you read about them on the endo page? NAC is one of the most important, from 2000 to 5000mg/day, at least 2000mg/day taurine which is vital for the health of the uterus, and 10,000iu vitamin D or more. It's so essential to know your level, you did say you were having a test done, did you get the results? I feel you will have to begin to reduce the progesterone slowly, as you can't afford more. But please continue with the vitamin D and the antioxidants. And are you avoiding all the sweet starchy foods? It's so important this, as excess glucose causes oxidative stress which leads to inflammation. I was so hoping the progesterone would have helped you, as you have so very many problems, but it seems to overcome them all very very high amounts would be needed. No one can afford that. Do let me know how you get on. Take care Wray
Aug 12, 2013
 laparoscopic surgery
by: Veronika

Dear Wray,

I´m so desperate and devastated. I have extreme pain and I can´t find anything that could help me (even pain medications do not work). I was at the gynecologists today and she found a large cyst on my right ovary (I´ve never had anything like that before) and PCOS on the left ovary (I had no cysts there for the last few months - before progesterone cream). That means I'll probably have to go for laparoscopic surgery next week. This is a tragedy for me, because I´m in very bad condition and every surgery makes my health problems worse.
I don´t know what to do and I regret using progesterone cream, I didn´t expect that it could cause such severe problems even in high dose (I ended on 2000 mg/day NATPRO). I have unbearable pain even in places where I've never had pain before, so it´s clear that endometriosis has expanded strongly.
I´d be very grateful if you could advise me something that could help me reduce oestrogen and get rid of the cyst (I know that you usually recommend Natpro, but I'm so scared of it now).

I was so desperate that I accepted recommendation of my gynecologist and I started taking Visanne (dienogest 2 mg) yesterday. I know that it won´t help me to solve the problem but I hope that it could help to reduce oestrogen (after the use of NATPRO) somehow. My gynecologist is not a big fan of Lupron or Zoladex depot.
I'd appreciate any of your idea how save the situation.

From your experience - is there a chance that everything (now after discontinuation of NATPRO) will return to its original state and how long can it take? Or will the high oestrogen persist and I have no other chance to save myself besides very high (no one knows how high) doses of NATPRO?

I use NAC (5000 mg/day) and vitamin C. I use NAC for 5 years now. I also use 20,000iu vitamin D. My vitamin D level is 70.8 nmol/l. And I use many other supplements and antioxidants (superfoods aso.). I don´t use taurine, because I read that it feeds candida quite strongly. I´m avoiding all the sweet foods, dairy, red meat, gluten,...
Before the use of progesterone cream, my pain was manageable, I only wanted to help myself to get pregnant. And I´ll end up in hospital with the cyst and severe flare up of endometriosis. I´m absolutely depressed...

Veronika
Aug 13, 2013
 laparoscopic surgery
by: Wray

Hi Veronika The cysts have been caused by the excessive oestrogen you now have. I can't remember if you are taking DIM and calcium D-glucarate, both these help reduce oestrogen. I did suggest you take them. Oestrogen is metabolised in the liver by glucuronic acid, the process is known as glucuronidation. Glucuronidation is one of the major detoxification pathways of the liver. It removes carcinogens, toxins, tumour promoters, the sex hormones ie, the androgens and oestrogens, mineralocorticoids and glucocorticoids, aromatic and heterocyclic amines, polycyclic aromatic hydrocarbons, various nitrosamines, drugs, fungi etc. It's then excreted in the bile, but an enzyme in the intestine called beta-glucuronidase reverses the glucuronidation process. It breaks the glucoronide bond between a toxin and glucuronic acid, and releases carcinogens, toxins and excess steroid hormones back into circulation. There's evidence beta-glucuronidase activity is increased in breast and prostate cancer. Calcium D-glucarate inhibits beta-glucuronidase, see here, here, here and here. Incidentally this enzyme is produced by undesirable gut bacteria, supplementing with probiotics suppresses the bacteria, and subsequently the beta-glucuronidase. Silymarin from milk thistle also inhibits beta-glucuronidase, plus it helps the liver detox. Oestrogen is broken down into 2 principle metabolites, 2-hydroxyestrone (2-OHE1) and 16-alpha hydroxyestrone (16alpha-OHE1). 16alpha-OHE1 is regarded as a potent oestrogen, whereas 2-OHE1 is a weak oestrogen. DIM increases levels of 2-OHE1, by doing so it also increases the ratio of 2-OHE1:16alpha-OHE1. This increased ratio is associated with a lower risk for breast cancer, see here. Other studies have found a protective role too. I also asked you to take iodine and selenium for your thyroid, but iodine also prevents breast and ovarian cysts, are you taking it? See here. Selenium is a potent antioxidant. You originally said you had PCOS but now you say you have no cysts for months, apart from the latest. Continued below
Aug 13, 2013
 laparoscopic surgery Part 2
by: Wray

Hi Veronika Please consider going on a Ketogenic Diet to reduce all glucose to the barest minimum. It's the most toxic substance known. There's nothing wrong with red meat, provided it's organic. Please consider doing the diet, it's even helped people with cancer, see here, here, here, here, here and here. Your vitamin D is very low, three times lower than it should be. You need to get it up to between 175nmo/L to 250nmol/L, although I feel you should aim for the 250nmol/L. It's evident the 20,000iu you're taking is doing little to help. You have so much inflammation all the vitamin D is being used up fighting it. I did ask you in June to have a test done, please consider taking 40,000iu per day to get it up high quickly, then have another test. If it's still low, take that amount for another month, and have another test. It's perfectly safe, see here. The paper concludes "Universal intake of up to 40,000 IU vitamin D per day is unlikely to result in vitamin D toxicity". It certainly won't with you, as you are so desperately in need of it. A lack of it reduces the benefits of progesterone, which is why that's not helping you. It's essential you get it up high quickly. I don't know where you found that info about taurine as it's rubbish. Taurine is a potent antioxidant, needed for so many things. If you fall pregnant, it's needed by the growing foetus, and after birth for breastfeeding. The newborn baby is not able to convert it from cysteine and has to get it from the mother's milk, see here, here, here, here, here and here. Continued below
Aug 13, 2013
 laparoscopic surgery Part 3
by: Wray

Hi Veronika Taurine is needed for a healthy uterus, a lack is found in endometrial cancer, cystic endometrial hyperplasia (which you say you have), fibromyoma (fibroids), and dysfunctional uterine bleeding, see here. In the body granulocytes and monocytes form N-chlorotaurine (NCT), an oxidant with known broad-spectrum anti-microbicidal activity. N-chlorotaurine is also an anti-inflammatory. It seems to be affective against methicillin-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans, see here. This study found that cholic acid and derivatives, one being taurocholic acid, had antimicrobial activity against C. albicans, see here. Another that N-chlorotaurine "demonstrated fungicidal activity against Candida spp.", see here. Without taurine the body cannot make N-chlorotaurine. Fish has the highest level of taurine. I'm sorry the progesterone hasn't helped you, although I'm sure in time it would. But you are in too much pain to wait for that. Please try those other supps I suggested, increase your vitamin D substantially, take the taurine and I'm sure with time the inflammation will reduce. I do hope things come right for you. Take care Wray
Mar 19, 2014
 how to eliminate NATPRO from my body
by: Veronika

Dear Wray,

I have serious problems since I started NATPRO. I described the problems in my last comment. After using very high doses of NATPRO for my endometriosis, I developed serious inflammation, extreme pain and large cyst on my ovary. I tried to add more and more cream but it was worse and worse. I ended with absolutely unbearable pain. After that I quit using NATPRO (I was on 2000 mg/day NATPRO). After all of that I don´t believe that NATPRO could ever help me. It actually ruined my life. Maybe it´s good for other people...
I had to start taking Visanne (dienogest 2 mg) which finally gave me pain relief. I still felt pain, but it was bearable. Last week I stopped taking Visanne after 7 months and I´m going to have laparoscopy next week. Today I visited my gynecologist and he was shocked to find very high uterine lining and again - cyst on my left ovary. I´ve never had any cyst before using NATPRO. I feel unbearable pain again (the same I had on NATPRO). Normally the lining should be low now with no pain, no cyst.
I´ve been taking DIM, IC3, calcium-d-glucarate, NAC, vitamin D (vitamin D level is normal now, I take very high doses), magnesium and many other supplements to reduce oestrogen all the months and there´s no change in my endometriosis and pain.
Than I found this information "It may involve going off the cream for as long as two years to wash the progesterone out of your system." Is it possible that I still experience those horrible symptoms because NATPRO is still in my body?! How long it will take to wash it out of my body? Several years?!! Can you please advise me how to remove NATPRO from my body faster?? I will go for a surgery to remove my endometrial lesions and I´m scared that it will immediately grow back again because of NATPRO being still in my body. I hope that there´s some chance to wash it out of my body earlier than after many years...! Because I can´t bear this enormous pain anymore.

I greatly appreciate your feedback. Thank you in advance.

Veronika (from the Czech Republic)
Mar 19, 2014
 NATPRO alternatives
by: Veronika

Dear Wray,

I have one additional question for you. As you know, I´m afraid to use NATPRO anymore... but with all that "progesterone cream" in my fat cells I need to try something else that could help me to get rid of it and help me with extreme oestrogen dominance and pain.
Could you please suggest me something else that may increase progesterone in my body somehow? Or should I try synthetic progesterone and wait until NATPRO disappers from my body (maybe years)...?
After this disaster with progesterone cream, I had to give up any hopes for having a baby and I´m depressed all the time. I´d really appreciate if you could honestly advice me something else than NATPRO (I understand that this web is about NATPRO, so you can optionally respond me on my email).
I´ve read about Maca that should balance hormones in a body - would you recommend trying it or is it the same risk as with natural progesterone cream (oestrogen could rise)?
Or Curcumin? - I heard that it could block the effects of natural progesterone cream...
Can anything else help to flush NATPRO out of the body? Sweating, baths, ... I don´t know... something... maybe some herbs... ?

Please help...

Veronika
Mar 22, 2014
 Many health problems and endometriosis
by: Joy

Hi Veronika

As Wray’s website states, she is on sabbatical and will not be responding to any posts until she returns.

Progesterone does not cause inflammation, excess estrogen does, Wray has provided all the backup research on this for you to read. Did you increase your vitamin D as she suggested and do you know what your vitamin D level is? Have you tried the Ketogenic Diet as suggested? When you say you quit using Natpro, did you stop just like that, with no gradual reduction? If you did this would also cause adverse symptoms. The uterine lining build up is caused by excess estrogen and NOT progesterone.

Having the endometrial lesions removed will not help you as you have not dealt with the oxidative stress that is causing it, they will simply grow back again in time. You will never rid yourself of progesterone, our body makes it all the time, both in men and women. You could try Maca but it is high in carbs.

Progesterone does not cause fat in our cells estrogen does. Estrogen is a mitogen, causing cells to proliferate. It is also an inflammatory, excitatory hormone. Progesterone is an anti-inflammatory hormone.

Other than what Wray has already suggested, I can’t add much else except to stress that it is not progesterone causing your problems, but excess estrogen.

Hope this helps you.
May 08, 2015
 L-arginine/L-Ornithine and endometriosis
by: Veronica

Dear Wray,

I´ve found your recommendation to take L-arginine (because studies have shown it restores gonadal function).
As you know I have endometriosis and I also have neuroborreliosis and ammonia accumulating in my brain and tissues. I read that in this case it´s good to take L-Ornithine/L-Aspertate which is used to reduce the ammonia and that ornithine is a precursor of arginine. But I´ve also found that Ornithine is growth hormone-releasing supplement and that Slater’s study (2003) indicates that Growth hormone releasing hormone (GHRH) and GH promotes endometrial proliferation and endometrial carciroma and GH may play a role in the progression of both endometriosis and endometrial canciroma.
So I´d like to ask you - is it possible that L-Ornithine or L-arginine supplementation could worsen my endometriosis? Or it has nothing to do with it?

I greatly appreciate your feedback. Thank you in advance.

Veronika
Jun 21, 2015
 hello
by: louna

Hello,
I am Louna 24 years old
My mother discovered that she have breast cancer stage 0 she is 54 years old , should I stop taking visanne ?
Jun 21, 2015
 hello
by: louna

Hello,
I am Louna 24 years old
My mother discovered that she have breast cancer stage 0 she is 54 years old , should I stop taking visanne ?
Jun 30, 2015
 Visanne
by: Joy

Hi Louna

All drug based contraceptives have a potential to cause harm, and cancer is a great concern. If your mother has just discovered that she has breast cancer, this should be enough for you to realise that it's dangerous. I suggest that you stop and either have the Copper T inserted which does not interfere with the body's cycle, or you could look at progesterone cream which can be used most successfully as a contraceptive. Please read How to use Progesterone Cream.

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