Is Progesterone a life sentence for people with estrogen dominance?

by Nataliya T.
(Massapequa, NY, USA)


A week ago, I have begun using Natpro with 100 mg daily. Almost immediately, the side effects became very pronounced: acne outbreaks, insomnia got worse, but what was even more frightening - my blood pressure readings went out of control - in spite of the BP meds I'm taking. I'm 61 y. o. with a life-long history of hypertension, recently diagnosed with subclinical Hashimoto's.

Of course, I contacted your company (the same way I'm using it now, having followed the link that was emailed to me), but for some reason, I didn't receive a reply. Perhaps, I haven't sent it correctly.

Being limited financially, I cannot afford the integrative doctor to consult one on one and my endocrinologist is against any supplementation, to begin with. She is just waiting for me to get worse in order to put me on synthetic thyroid hormones. But I'm, quite contrary, trying all I can to get better, counteracting inflammation with supplements, doing a mild detox with fulvic acid and other supplements of that kind, digging for the root causes.

So without knowing how to proceed with Natpro, having concluded by symptoms only (and your questionary) that I apparently struggle with estrogen dominance, I have decided to take a leap of faith and to increase the dosage - since your general guidelines suggest just that. Besides, reading your site's posts, I realized that stopping Natpro abruptly is not a good idea, and it takes up to six (!) months for progesterone to counteract estrogen.

I didn't know how much more progesterone my body can tolerate (my weight is 110 pounds), so I increased just a bit - morning and evening dosages of approximately 75 mg, so it's 150 mg daily.

The side effects subsided just a tiny bit, but not quite. Besides, on top of that, I'm having new trouble now with my eyes. I visited an ophthalmologist and he said there is a threat of retina detachment.

It's quite scary to take a plunge with higher doses if your BP readings jump to 180/110 at times! All my maternal relatives died of a stroke at a young age. Clean diet, yoga, breathwork helped me that far.

To tell you the truth, I'm not thrilled with a perspective to get stuck with progesterone replacement for the rest of my days. My insurance doesn't cover detailed lab work (hardly - thyroid panel), and the Natpro is not cheap. I'd sacrifice the other supplements I'm currently taking - only if I'm sure that progesterone can reverse my autoimmune condition for good. Or if by using it for a long time (gosh, not forever!), my TSH and TPO antibodies would drop... But I am confused and scared to experiment at this point.

And really, do I have to use progesterone forever now? Could the withdrawal be just as bad as the initial introduction of Natpro?

So, would you suggest for me to continue with Natpro (meaning - increasing doses) or I'd better stop using it?

Really hoping to receive your reply,


Comments for Is Progesterone a life sentence for people with estrogen dominance?

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Oct 20, 2021
Is Progesterone a life sentence for people with estrogen dominance?
by: Joy

Hi Nataliya T

One will always experience strange things happening when progesterone is first used, this includes acne.  The body needs to adjust to progesterone therapy which can take between 2-6 months.  

Progesterone probably aggravated your BP. However, if the high BP is caused by vasoconstriction, progesterone can help as it's a vasodilator. Sharp declines have been observed in the early and late luteal phase of women when progesterone peaks.  I realise that you are 61 and in Menopause but thought to add this about the luteal phase. If the high BP is caused by excess aldosterone it can help. The hormone aldosterone causes sodium and water retention, which increases blood volume and pressure. Progesterone inhibits aldosterone, by occupying the same receptor sites, see here and here.  BP also increases if the renin-angiotensin system is activated, it's sometimes called the renin-angiotensin-aldosterone system. If blood volume drops the system kicks in. Renin is made by the kidneys, this stimulates the production of angiotensin, which is a potent vasoconstrictor, which increases BP. Angiotensin also stimulates the release of aldosterone, which of course causes sodium and water to be retained, so BP goes up. Essential hypertension accounts for 95% of all cases of hypertension, i.e. it's idiopathic or not known. Although a number of factors are known, obesity, insulin resistance, high alcohol intake, high salt intake, ageing, stress, low potassium and calcium intake. They are even suggesting our genes are responsible! But one thing which is always overlooked, a lack of Vitamin D3 causes the renin-angiotensin-aldosterone system to come into play. I believe this is the primary cause of high BP, which is increasing the world over. Due to the misguided advice of governments to avoid the sun, by covering up or using Sunscreens.  People who live in a 'sunny' country think that they are getting enough sun, they aren't.  Studies of people living on the equator have found a lack of vitamin D3 in the participants. Please have a test done, for more info please see the Vitamin D Society website. Please look at these papers on the effect low vitamin D has on BP here,  here  and here.  A lack of vitamin D3 reduces the benefits of progesterone.  As you have a long history of hypertension, please take note of what has been mentioned.  
Acne could be that your testosterone level is high for one thing.

Run that by me again!  Your endocrinologist is 'waiting for you to get worse" really?  That is unbelievable.  By the way, a lack of vitamin D3 also affects the thyroid.

Progesterone therapy can take between 2-6 months before benefits are felt.  Some need a longer time and some are lucky enough to experience it's benefits much sooner.  I keep stating here that what suits one may not suit another.  We are all different.  The amount of Natpro that you are using is very little in comparison to others.  Some use as much as 400mg and others 800mg until their symptoms improve then they reduce the amount used.  

Progesterone therapy is a lifelong commitment, the moment you stop, all adverse symptoms will return sadly.  Progesterone needs to be the dominant hormone at all times.  Only you can decide if you wish to use progesterone indefinitely.  I will never stop using it, I have been using it for 17 years now.  

Should you wish to wean off progesterone, please do that gradually, it's kinder on your body.  Just be aware that your adverse symptoms will return.

Oct 21, 2021
Seems like Progesterone IS the companion for the rest of the life journey
by: Nataliya T.

Hi Joy,

Thank you so much for your thorough reply!

Most of all, I appreciate what you said about the relation between progesterone and the renin-angiotensin-aldosterone system. It rings the bell because the only BP medications that work for me belong to angiotensin receptor blockers. If progesterone will help to lower blood pressure, it would be a major breakthrough for me!

As for vitamin D3, since the pandemic started, I take 5,000 IU daily. The ocean beach is my favorite place to be and - living on Long Island - I do yoga in the swimsuit in my backyard until November - without sunscreen. But I thank you for pointing out the antihypertensive effects of vitamin D.

Hypertension runs in our family. I hope it will help me to persuade finally my hypertensive cousins who are still concerned about vitamin D overdose - in spite of my suggestion to take the D3/K2 combo in high doses. They live in Siberia and both came down with covid.

In our healing journey, sometimes we have to be "the scientists of our own laboratory" which involves risk. If progesterone will be that missing magic piece of the puzzle in my quite solid (so I thought) pack of supplements, I would stick with your company for as long as it takes. And now I'm going to order a three-pack bundle of Natpro.

Thanks again!

Oct 22, 2021
Seems like Progesterone IS the companion for the rest of the life journey
by: Joy

Hi Nataliya

Thanks for your kind words.  If only people would realise that many of the so called ‘modern’ diseases can be prevented or cured by progesterone therapy.

Please don't forget to add those co-factors when taking D3, they are extremely important.  The thing about getting enough D3 from the sun confuses people.  Unless one can enjoy the sunshine with absolutely no clothing on at the hottest time of the day for about 20 to 30 minutes with NO sunscreen, every day, then yes one would be getting enough D3.  None of us can do that. Supplementation is vital.  You would be getting more than most.  As for D3 toxicity.  It really is impossible.  To get my level up where it should be, bearing in mind that I live in a sunny country, South Africa, I thought that my level would be optimal, how wrong was I!  I took 10 000iu's for 8 months, then dropped down to 5 000iu's per day EVERY day.  Perhaps your family could read the Vitamin D Society link given to you and also Grassrootshealth, link on the D3 page given to you.  You might also like to read this.  

Please keep us posted on your progesterone journey.  Just a little reminder, if not used correctly it will not work.  We are here to help you through this.

Go well.

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