I was on and off the depo shot for 8 years total. I am 46 years old now and went off of it January of 2011. Since i have been off i have lost 30 pounds,dont want to eat,depression,acne real bad,insomnia,tired all the time, and have pains down there every once in a while. No period as of yet. I just dont feel the same. I know that the depo has a progesterone in it. Could i need progesterone therapy now and never knew it because of being on the shot.Please someone help me on this. I have had no tests because my doctor says there is nothing wrong except i may need a antidepressant. I am not going to get on pills if i dont need them. As of 1 1/2 years ago my Dr. saw no signs of menapause thru my check up.