Aldosterone resistance and progesterone


I just started using progesterone and I've read that using amounts such as 100-2000 mg actually inhibits aldosterone and I'm really scared because I have low cortisol all throughout the day (I have adrenal fatigue. Which means I most likely have low aldosterone anyways.. so I'm not sure what to do.. do I continue using progesterone???

I'm also taking some sea salt and potassium for my adrenals....please if anyone could answer if really appreciate it....

Thank you.

Comments for Aldosterone resistance and progesterone

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May 28, 2017
Aldosterone resistance and progesterone
by: Joy

Perhaps these pages will help you:

Effects of progesterone

Ray Peat article

May 31, 2017
Still not sure
by: Rnaxand

Okay I read it but I'm still a bit confused and scared....Joy what do you think of the information on this site?

It suggests that progesterone may cause cortisol and aldosterone resistance and I have been feeling weak lately. I feel numbness in my arms, legs, hands and I'm currently taking 200mg progesterone cream....sorry for asking so many questions, I'm just not sure what to do anymore :(

Jun 01, 2017
Still not sure
by: Joy

Hi Rnaxand

If I remember correctly you are not using Natpro progesterone cream, that could be your problem. If I am correct you need to adjust the cream that you are using to equate to that of Natpro. You can find the info on Natpro on the order page.

Have you given the cream a chance to work? Many people expect overnight fixes which will never happen, it takes 2-6 months of the correct use of progesterone. The body goes through ups and down during this adjustment.

Sep 05, 2017
same here
by: marta

I have exactly the same problem and doubt. I use 200mg Natpro, been doing for last too weeks. I'll give it time but for now feeling much worse, potassium and cortisol is very low. I'm hoping it helps but I'm very scared at this point and confused.

Did you find any answer regarding this? having continued did it get better? If I increase more i'm so weak it's scary so I'm going slow as I've been in bed for the last two years, legs get numb and eyes hurt alot, I also have fibroids and low progst.

Sep 06, 2017
Same here
by: Joy

Hi Marta

As mentioned further up, it takes 2-6 months before positive signs are achieved. A standard rule is that if the amount used does not help, to increase the amount used. You will have to experiment with this to see what suits you and your symptoms. We are all different requiring different amounts and different things. I can tell you though, if you have fibriods you need to use between 400-500mg per day.

Please read the Fibroid page below. It should be used every day with no breaks for 2-6 months, longer if symptoms are severe. Fibroids are caused from oxidative stress and unless the Inflammation is dealt with you will battle. Some women are lucky enough to get away with using 200mg Natpro per day, others not. I suggest using this protocol which is also excellent for heavy bleeding if you still have a monthly cycle.

* 400-500mg Natpro Progesterone Cream per day
* 2000mg N-Acetyl-Cysteine (NAC) per day
* 2000mg Taurine per day
* 5000iu's Vitamin D per day, more if deficient
* 1000mg Bioflavanoids per day

If you have low progesterone then you need to supplement correctly. Supplementing with progesterone is very helpful for adrenal exhaustion. The adrenals first make progesterone before converting it into cortisol, one of the stress hormones. If stressed they rob other sources.

Vitamin D3 is very important, it must be at optimal range at all times as per the page below. Often doctors say that levels are 'normal' or 'fine' when in fact they are not. A deficiency reduces the benefits and is vital for fibroids. Co-Factors are needed when take Vitamin D3, Magnesium being considered the most important. Vitamin K2, Zinc and Boron are also important.

Please read these pages and the references as they will help you. If progesterone is not used correctly you will battle.

Oestrogen dominance

How to use progesterone cream



Vitamin D3


Sep 07, 2017
by: Rnaxand


I'm now using 375 of onas progesterone and every time I increase I do feel slightly better but for some reason I am just sooo exhausted and fatigued and still bed ridden.

I'm thinking maybe the progesterone is trying to fix my adrenal exhaustion before fixing my estrogen dominance?? I don't know anymore I'm just so sad all the time now....I'm going to increasen to 600mg and see if anything happens, I feel like there's a lot of stress in my life plus I got a cold so I'm going to increase and pray that it works and hopefully it works for you too!!

Good luck!!

Sep 07, 2017
by: Rnaxand

Hi joy,

I have a question. Is it possible that since my adrenals and thyroid are extremely fatigued that maybe progesterone is trying to fix them first before fixing estrogen dominance?? If I increase to 600mg will it work faster do you think?

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