Urgent help needed. Progesterone receptors downregulated... how long a break to upregulate??


I wonder if you can help me? I've been using natural progesterone cream at min 250mg for 4 months continuously, it stopped working a month ago. I assume this is because I didn't take a break. I do not think that dermal fatigue is the problem as I have been using it vaginally at the same dose for the past few weeks and it has still not worked. From my reading the receptors on the cells around your body that the progesterone flows to via the blood can downregulate (cellular decrease in the number of receptors to a molecule, which thereby decreases its sensitivity to progesterone)... do you know anything about reversing this? If I took a break, how long a break would I need for my receptors to start to respond again?

Many thanks for your help!

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Mar 27, 2018
Urgent help needed. Progesterone receptors downregulated... how long a break to upregulate??
by: Joy

There are a number of reasons that causes progesterone levels to drop, when it drops more progesterone is needed.

* lack of or drop in Vitamin D3 levels
* high estrogen
* high testosterone
* high LH
* high FSH sugars of any kind
* large meals
* alcohol
* stress
* insulin resistance
* high level of phytoestrogens in the diet

Diet is so very important. Wheat is particularly bad as is sugar, in fact all carbs should be avoided as much as possible.

I have been using Natpro Progesterone Cream for 14 years now with no breaks at all, I am now 62. Progesterone should be used no less than twice a day, more and again at night. Insert your night time dose in your vagina.

You could try taking a break to see if that will help you, but I really do not think that it will. If you do decide to take a break please use progesterone cream by following your cycle as explained on the, How to use progesterone cream page, given below.

A vitamin D3 deficiency reduces the benefits of progesterone. Optimal levels is between 70-100ng/mL.

Please read these pages on the website:

How to use Progesterone Cream - https://www.progesteronetherapy.com/how-to-use-progesterone-cream.html

Estrogen Dominance - https://www.progesteronetherapy.com/estrogen-dominance.html

Stress - https://www.progesteronetherapy.com/definition-of-stress.html

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