Urgent help needed. Progesterone receptors downregulated... how long a break to upregulate??
I wonder if you can help me? I've been using natural progesterone cream at min 250mg for 4 months continuously, it stopped working a month ago. I assume this is because I didn't take a break. I do not think that dermal fatigue is the problem as I have been using it vaginally at the same dose for the past few weeks and it has still not worked. From my reading the receptors on the cells around your body that the progesterone flows to via the blood can downregulate (cellular decrease in the number of receptors to a molecule, which thereby decreases its sensitivity to progesterone)... do you know anything about reversing this? If I took a break, how long a break would I need for my receptors to start to respond again?
Many thanks for your help!