I'm 57 and I've been on bioidentical hormone replacement for 14 years or so. Originally, the doctor put me on progesterone to alleviate the terrible menstrual cramps I had due to my 'mild' adenomyosis. I was also diagnosed with a small fibroid (in 2010).
The unopposed progesterone gave me migraines and trouble sleeping so I stopped it. Soon after that, at 43, I went into early menopause (which was the idea). However, I had terrible mood swings, hot flashes etc. I went to a bioidentical hormone specialist, had a saliva test and blood analysis and was put on a combination of Triest and Progesterone creams. The dosage changed many times over the years, but I rarely felt balanced. I seemed to flip-flop back and forth between several sets of unpleasant symptoms, but I lived with them. I am currently on BiEst and Progesterone cream. My dosage was Bi-Est 80:20/0.02 ML cream twice daily and Progesterone 75MG/.02ML cream twice daily for the last year or so.
I recently started to get terrible heart palpitations, severe anxiety, and depression. My levels were 114 pmol/L for Estradiol and 12 nmol/L for Progesterone. The doctor switched me to a 50:50 ratio of BiEst 1.6MG/).2ML cream twice daily and dropped my Progesterone from 75 to 25. The palpitations stopped and the anxiety improved. However, after a few weeks I started to get menstrual-type stomach pain and cramps, and migraines. Then I started bleeding - for the first time in all these years. In a little over a month, my Estradiol had gone to 97 and Progesterone to 3. The spotting lasted a week or so. I had an ultrasound and my endometrium had thickened by 2mm.
Last week, I went to the gynecologist, who removed a small polyp from my cervix. He also told me go back to the 75MG dosage of Progesterone. In two weeks my Estradiol dropped further - to 47 and the Progesterone rebounded to 5. I don't understand why my estrogen is continuing to drop, despite the stronger prescription.
I am on constant painkillers for the cramps and pain, and I am bleeding again. Now I don't know if the bleeding is a result of the hormones or the procedure to remove the polyp. Incidentally, my FSH fluctuates between 23 and 27, but I had not bled in 14 years, so this is pretty frightening.
I want to understand what is going on with me, but my doctor is not giving me enough information. I see him again in a month.
I would welcome any information any of you might have.