Hi. I am just beginning to digest all this information. My health has been declining for the past 4 years. Not that it was great before that. I underwent fertility treatments for a good 4 years. Had 2 beautiful children. Shortly after the birth of my second child my mom was diagnosed with colon cancer and died within a year. On the one year anniversary of her death my husband was diagnosed with terminal cancer and died approx a year later. I was left with a 4 and 5 year old. Needless to say I experienced a great deal of stress. I went along the best I could. I began to experience extreme lethargy, cold, extremities, periorbital swelling, dry eyes. I felt like I was slowly dying. I am a registered nurse. I felt like I might be experiencing hypothyroism. This is where my trouble really began. I made time to see a doctor. My thyroid studies came back within normal limits. So needless to say I was placed on antidepressants which never really corrected my problems. The last antidepressant I was placed on was Wellbutrin . As the dose was increased my symptoms became worse. Crushing fatigue, total apathy. There were days I was so cold all I could do was wrap up in a blanket. I began to put on weight which was never a problem for me. When I updated the Dr. She had me keep increasing the dose. I began to break out with cystic type acne, constant vaginal bleeding. Against her advice I stopped the Wellbutrin. Shortly there after I stumbled upon Ray Peats site. He has extensive information on serotonin. Which, after educating myself,may be a very dangerous hormone to be stimulating. Looking back now, I feel I am estrogen dominant. I feel my thyroid is not functioning correctly, but I'm not sure which came first. I've done a lot of research and started using progesteron cream and I plan on following Dr. Peat's recommendations. I have been using the cream somewhat liberally over the past 7 days. I feel awful. Puffy, swollen eyes, headache,terrible fatigue low body temp 96 to 97.4, swollen tongue. I had to miss a day of work I felt so bad. I rarely miss work. I'm a pretty strong person. Could my progesteron be too high. I am still having vaginal bleeding. Is it possible to feel worse before I feel better. I would appreciate any input you could offer.