by Christine
(Woodland, WA)

Hi, Every time I use progesterone cream I get so thirsty. This also happens to me the first 3 months of being pregnant. Is the thirst the result of estrogen or progesterone?

Comments for Thirsty

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Oct 07, 2014
by: Anonymous

I have the same question with the thirst. But, I see you got no answer either. I am sorry. I don't know the answer to that, but I have the same question. But, no response to it either.

Oct 08, 2014
by: Christine

So I did a little digging and progesterone blocks the mineralocorticoid receptors which alters aldosterone. Aldosterone regulates salt homeostasis. Long story short...I added more potassium to my diet and that helped. I also pee like crazy on progesterone so I assume it working and doing the correct things in my body.

Oct 11, 2014
Thirsty and peeing
by: Anonymous


I see you did some research, but you may need to so some more. I am not an expert by any means. I do have some experience with the adrenal glands and their function. The alderesterone you mentioned is very vital for regulating he sodium and potassium levels in our bodies. If progesterone blocks the receptors, and alters the alderesterone, I would think that is not a good thing for our bodies, especially if you are having to add potassium. Please, do some more digging. I am glad you reported this. I should not be taking progesterone if it blocks the receptors in the adrenal glands. Thank you for letting me know.


Jan 18, 2015
Extreme thirst!
by: Autumn

I get thirsty on only 10 mg of cream. At 20 mg I get a constant headache due to dehydration. I would like to up my dose of cream (I only do 10 mg a day). Curious to know if anyone following this thread has any new experiences or information. It's so frustrating. It took a while to figure out what is wrong with me, and now that I know and want to correct it - a road block!

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