Spotting at mid-cycle (2 weeks) on 166mg prog / day

by Gulnar
(New Jersey (US))

Hello Wray,

I've been taking 1 tsp of progesterone per day for the past 6 weeks. (My Pg / E2 ratio was 17 in August. Progesterone was very low at 24 pg/ ml while estradiol was within range at 1.4 pg/ ml). For the 1st month it really helped my migraines. However, this month I have begun spotting on the 14th day of my cycle (this never happens - I have always had very regular periods). And I have had a migraine for the past 2 days.

I have been taking the progesterone every day as I think this was your advice to someone else on the forum whose lab tests were was extremely low. I was planning to begin the 2 weeks on / 2 weeks off cycle in another month or two.

Could you provide any advice re why I am spotting / having migraines again?

BTW - my skin has greatly improved after taking the progesterone.

Thanks very much for your help in advance,


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Nov 04, 2013
Spotting at mid-cycle (2 weeks) on 166mg prog / day
by: Wray

Hi Gulnar Progesterone can upset the cycle when first using it, making it earlier or later than normal. It does settle with time. The first month is often good, but Oestrogen Dominance can kick in, which it seems to have done with you. We do have a page on Migraines, often 400mg/day is needed, plus high dose vitamin D. It is best to use the progesterone daily for a few months, to ensure it becomes dominant. Your ratio is very low at 17:1. Please have a look at the Saliva Tests we run on the Natpro, you’ll see it’s absorbed very well, as levels of progesterone shoot up to over 600:1. If your cycle is 28 days, the 14 on, 14 off is correct. But if it’s longer or shorter it’s not, see our page on How to use progesterone cream and our Menstruation page. I’m delighted your skin has improved, it often does help it as it suppresses any excess testosterone responsible for the skin issues, see here. If bound to SHBG (sex hormone binding globulin) testosterone becomes inactive, progesterone raises levels of SHBG, see here, so preventing the rise of free testosterone, and often severe PMS. Take care Wray

Nov 10, 2013
Break through blleedng a few days before...
by: Anonymous


I'm writing for my girlfriend, who wishes not to be on here.
She was applying +/-400mgs/day and did this for 45 days - until she ran out.
Last month, 5 days before her period would normally start, she experienced b.t.b., which then morphed into the period.
And this month, the same thing happened again.
At 400mgs/day I wouldn't think this was estrogen dominance rearing its head.
For reasons of her own, she is hoping to stop the monthly bleed all together.
Any ideas; any input would be greatly appreciated.
Thank you

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