Question on when to start progesterone when trying to get pregnant with luteal phase defect

by Caroline


My husband and I have just begun trying to conceive, but I have been tracking my cycles for years and have discovered that I have a luteal phase defect and low progesterone. I read that you should start taking the progesterone in the 50 hours prior to ovulation, but wanted some clarity on that.

I usually use LH test strips to determine when I'm ovulating. I typically get 1 or 2 "high" strips before my peak. Should I start the progesterone when I first see the "high" days or when I see my peak day? I usually ovulate quite quickly after my peak day. How much should I take before ovulation? 200/mg?

Since I have a short luteal phase (longest has been 11 days, but normally 8-9), should I bump up to 300/mg a day? Or stay at 200mg?

Thanks so much in advance! So glad I found this resource!

Comments for Question on when to start progesterone when trying to get pregnant with luteal phase defect

Click here to add your own comments

Jul 03, 2019
Question on when to start progesterone when trying to get pregnant with luteal phase defect
by: Joy

Hi Caroline

There is a Pregnancy page which explains this in detail. A low dose of progesterone will not help. 100-200mg/day or more progesterone should be used, depending on symptoms. In some cases up to 400mg/day will be needed. It should be used from ovulation, or during the 50 hour pre-ovulatory surge. You will have to experiment to see what suits you but I suggest that you use 200mg and see how you get on. Use a good organic cream such as Natpro which is a 3% cream. If used too early i.e. 7 to 8 days before ovulation, which is when many women are told to start it, progesterone can act as a contraceptive, but usually 200mg/day or more is needed. So starting too early can prevent the chance of falling pregnant. Progesterone therapy does take time, so patience is needed.

No progesterone should be used before ovulation which is called the folliculr phase. If trying to conceived, progesterone should only be used at luteal phase. Please read the How to use progesterone Cream page.

Jul 04, 2019
Thanks!—progesterone for luteal phase defect
by: Caroline

Thanks Joy! I have the Natpro cream and will try using the 200mg/day.

I still have some confusion around when exactly to start the cream. I know that it can be used 50 hours before the surge, but what is the best way to determine that? If using LH test strips, when should I start using the cream? At the "peak" day or when the test line starts to get darker.


Mar 04, 2022
Trying to conceive
by: Stacy

I also would like to know what she asked above. If trying. To conceive should we start progesterone when we see our peak on an LH strip or when the line starts to get darker right before the peak, like the day before we get the peak LH strip?

Mar 06, 2022
Trying to conceive
by: Joy

Hi Stacy

The pregnancy page explain this in detail but to recap ....

Progesterone must only be used at ovulation, or during the 50 hour preovulatory surge if pregnancy is the aim.

Take temperature readings or use a mini microscope to help check for ovulation.

On no account must the progesterone be stopped if conception is suspected, otherwise it could cause a miscarriage.

It is essential to continue the progesterone over the first 2-3 month critical phase, particularly the first 2 months.

It is also essential to bear in mind that stress can cause a miscarriage
The nearer intercourse takes place to ovulation, the greater the chances of conception.

Use at least 100-200mg/day progesterone, possibly more. It should always be used a minimum of twice a day by dividing the amount.

Make sure sufficient nutrients are taken to support the pregnancy, particularly vitamin D and taurine.

Avoid all skin care, foods and drinks which contain endocrine disruptors and other toxins, these can cause epigenetic changes in the foetus.

Click here to add your own comments

Join in and write your own page! It's easy to do. How? Simply click here to return to Blog contributions.

Share this page:
Find this page helpful? Please tell others. Here's how...

Would you prefer to share this page with others by linking to it?

  1. Click on the HTML link code below.
  2. Copy and paste it, adding a note of your own, into your blog, a Web page, forums, a blog comment, your Facebook account, or anywhere that someone would find this page valuable.

Search over 8,400 pages on this site...