Progesterone/Oestrogen ratio ?

by Alison

I would like to determine my Estrogen/Progesterone ratio according to my lab test results and what action should I take. I'm not sure if I am oestrogen dominant? and what I should be taking/doing.

I am 48 years old suffering with anxiety, mostly mental symptoms (obsessional intrusive thoughts/worry) but some physical, head fuzz, churning tummy, same thoughts every day, which are always 'there'.

Still having periods but they have been all over the place for the past few years.

Here the lab test results, these were taken on day 7 of my period.

Oestradiol level - 214 pmol/L
( I think this equates to 58.2893 pg/ml but maybe you could check the conversion?)

Progesterone <1 nmol/L
(I think this equates to 0.3145 ng/ml but again maybe you could check the conversion)

Thanks so much.

Comments for Progesterone/Oestrogen ratio ?

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Sep 06, 2017
Prog/oest ratio
by: Rachel

Hi Alison!

Where did you get your tests done if you don't mind me asking? Where they blood tests of saliva/urine?

I'm in the UK too and I have suffered exactly the same symptoms as you, and we're the same age. I can only ever get blood tests done by my GP, as i can't afford private saliva tests.


Sep 06, 2017
Progesterone/Oestrogen ratio?
by: Joy

Hi Alison

Your progesterone:estradiol ratio is 5:1, this is very low, it should be around 600:1 before one feels good. Please refer to the Hormone Testing page given below for more information and the correct way to work out ratios. In order for this to improve you need to use a good natural progesterone cream such as Natpro.

Your symptoms are all crying out Estrogen Dominance. You are also in Peri-Menopause which starts at around 35 when progesterone levels start to drop. It can be a torrid time for most women but it need not be with the correct use of progesterone which will also prepare you for Menopause. This explains your erratic periods.

On top of that, a vitamin D3 deficiency reduces the benefits of progesterone. Do you know what your level is? Unless supplementing you will be deficient. Co-factors are needed.

Please read the following pages and the references as they will help you to understand exactly how to use progesterone correctly should you decide to use it.

How to use Progesterone Cream -

Estrogen Dominance -

Peri-Menopause - Peri-Menopause -

Menopause -

Vitamin D3 -

Magnesium -

Hormone Testing -

Sep 07, 2017
prog/oestrogen ratio
by: Alison

Thank you Joy and Rachel.

Rachel - my doctor did the blood tests for me but I did have to push for them. Just check what day of cycle you need to have them, I think around day 21 is best I have been told.

Joy - Thank you so much for this information - I REALLY appreciate it! Did you use my original readings to get to the 5:1 ratio? I thought it was about 5:1 but not sure I had carried out the calculations correctly. So maybe you could verify this for me. Also, would it have made any difference that I had the blood tests on day 7 of my period?

Thanks again. x

Sep 08, 2017
prog/oestrogen ratio
by: Joy

Hi Alison

The test results that you provided were used. It does make a difference for accurate results. The test should be done approximately 7 days after ovulation or before bleeding.

Sep 11, 2017
Blood Tests accurate ?
by: Anonymous

Thank you Joy, so I may not be progesterone deficient then ? How much difference does it usually make? I'm annoyed that the doctor didn't tell me this. I am just wondering if my ratio is actually low if it makes such a difference as to when the blood tests were done? What's your opinion on this? I don't think doctor will repeat my blood tests.

Thank you again.

Sep 12, 2017
Blood tests accurate?
by: Joy

Hi Alison

Incorrect. You are very low in progesterone. The aim is to make progesterone the dominant hormone at all times. Your progesterone:estrogen ratio needs addressing. Progesterone should be in the range of 600, yours is very low at 5. Did you manage to read the links and study papers given to you as this is all explained in those pages?

Your doctor should have advised you when the correct time is to take the tests. You can always order them online if you decided to test again. ZRT Labs in the USA and Birmingham Hospital in the UK do them.

Take care.

Sep 13, 2017
Thank you!
by: Anonymous

Thank you Joy for replying, I so appreciate it, I cannot tell you how grateful I am xx

I'm looking forward to trying Natpro and will report back.

Rachel, how are you now ?

Alison x

Oct 02, 2017
How much
by: Alison

Hi Joy, I have been using Natpro for a couple of weeks. How much should I be using please? And how much is in one pump?

Thanks so much.

Oct 03, 2017
How much?
by: Joy

Hi Alison

It does state on the website and the order page that one full pump delivers 50mg/1.5ml of cream. I suggest you try 200mg per day as your ratio is very low. You may need to use more if you experience severe estrogen dominance symptoms. Nothing less than 100mg Natpro should be used. It must be used no less than twice a day, so whatever amount you decide to use, split that - morning and again at night.

Please do not forget Vitamin D3 and the co-factors in order for progesterone to work optimally.

Oct 03, 2017
thank you
by: Alison

Thank you Joy.

I have been using this amount and will continue to do so. I am also taking vitamin D. How long do you think it will take to get my levels back to normal? xx

Oct 04, 2017
Thank you
by: Joy

Hi Alison

That is difficult for me to say as we are all different. What suits one, may not suit another. Time and patience is needed.

Apr 17, 2018
New ratio
by: Anonymous

Hi, my new results are :
Serium Oestradiol level (4465) - 508 pmol/L
Serum Progesterone level (XE2dq) - 42 nmol/L

What does this mean?

I'm struggling to afford Natpro as it's £48.00/bottle and 1 bottle lasted me about a month.
Do I need HRT and can I insist that my doctor prescribe it?
I'm in the UK.


Apr 19, 2018
New Ratio
by: Joy

New Ratio

Your ratio is 83:1, it should be around 600:1 as mentioned in the Hormone Testing page above. You need to use more progesterone.

I am sure that your doctor will prescribe progesterone for you if you can't afford Natpro.

Take care.

Apr 19, 2018
Help ?
by: Alison

Hi Joy, could you advise on my last comment please. I really could do with some advice, thank you.

I will be purchasing Natpro if I have too and will just have to find the money somehow, willing to try anything. My doctor is no use.

Thank you.

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