Progesterone saved my sanity

by Kassi
(Irondale, MO)

For years, doctors thought I was depressed even though I kept telling them my problem was somehow hormone related. I only knew that because my PMS was so bad. PMS caused severe mood swings, anxiety, weird food cravings -- peanut butter, mayonaise and pickle sandwiches!! It tastes great, but who would eat that unless their hormones were out of whack?

Over the years, my PMS continued to get worse and lasted longer and longer -- when I finally got help from people who understood what was going on. My PMS was lasting two weeks and with the period lasting five days, I had about one good week a month. I was at my wits end. I was fortunate enough to get in touch with doctors that use conventional medicine and homeopathic medicine to treat patients.

I already knew from past experience that I wanted nothing to do with synthetic hormones - they made me absolutely psychotic. Basically, the synthetic hormones made my symptoms even worse.

Luckily I was put on natural progesterone and have felt much better; I have been taking progesterone since I was 38 - will be 40 in June.

It is important to stay on the progesterone and communicate with your doctor if things don't seem to be working as well as you think - the dosage may need to be adjusted. I have to take the progesterone as if I were in menopause - that is how bad my PMS is. I take the hormone for three weeks out of the month. It has made a world of difference. I am still crabby but I am not like Norman Bates if you know what I mean. The depression and anxiety are almost nonexistent. I still have moments, but I think most of us do.

Hope this helps someone. Don't give up hope until you try progesterone.

Comments for Progesterone saved my sanity

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May 31, 2008
Progesterone saved my sanity
by: Wray

Hi Kassi Progesterone also saved my sanity! Thanks for your comment and encouragement! Take care Wray

Nov 13, 2008
by: ann

Can I ask how much you take and if you take the same dosage every day for those 3 weeks? I am trying to figure out my dosage. All I get from health care providers is "it's different for everyone", well thanks! Do you think progesterone builds up in the body? Then what?!

Nov 17, 2008
by: Wray

Hi Ann. When to use the progesterone and how much is dependant on the severity of symptoms and what stage a woman is in. If it's used during the reproductive years it should only be used for the last 14 days of the cycle. If used before then it stops ovulation.

During menopause it can be used every day. If symptoms are severe it will be necessary to use a high dose initially, then reduce till the optimum is found. It won't build up if used in this manner. We do have a web page on how to use it and another on oestrogen dominance which you should also read. I'll give the links below:

How to use progesterone cream:

Estrogen dominance

Hope this helps, take care Wray

Jan 06, 2009
Dosage and what days of the month
by: Diane

I too have been on progesterone for 3 years now. I'm STILL trying to figure out what dosage to take and when? Just when I think I found a good dosage amount and the amount of days to take it, the next month changes. My doctor changed me from 2,150mg of SR to 300mg of TR. What's the difference between SR & TR?

Jan 07, 2009
Dosage and what days of the month
by: Wray

Hi Diane. The dose will change all the time. Unlike a drug it's up to the individual to use more or less as required. For instance stress drops progesterone levels sharply, so use more if stressed or if you know you're going into a stressful time. It doesn't matter if the stress is good or bad either, it has the same affect.

Large meals drop progesterone levels, dark days or lack of light drop levels too. Eating meat which originated from animals fed oestrogen would upset the balance. Our food, water, air and all the skin care we use all contains oestrogen, this would upset the balance too. So if you feel you need to use more, then do so. There are now so many abbreviations, you will have to explain what you mean by SR and TR. Take care Wray

Jan 07, 2009
form of delivery?
by: Ann

I would like to know what form of delivery is thought to be best by the "industry" and also what forms have worked the best for anyone. Right now I am on a compounded skin cream, which I am questioning the actual amount absorbed because I am still experiencing estrogen dominant symptoms such as extremely dry (and I mean hard to open and painful!) eyes, only at night. I am also having some water retention/swelling, most noticibly in the extremities, where I hadn't had any before. I take 100mgs. days 7 through 23.

Still trying to figure it all out...

Jan 08, 2009
Form of delivery?
by: Wray

Hi Ann. It does take time to work. You don't mention how long you've been using it, but I've found it can take from 3-6 months to settle symptoms. The worse the symptoms and the longer their duration the longer it will take.

You are using a good dose, but you might consider using 150-200mg for the next month, this will help. Initially progesterone activates the oestrogen receptor sites, so making oestrogen the dominant hormone, hence the water retention as oestrogen causes it. Progesterone is such a good diuretic it is now being given via IV transfusion to brain trauma victims to prevent the oedema that forms.

I suggest you take 5ml omega 3 fish oil, plus 15-60ml flax oil as a salad dressing, this will help your eyes. As for which is the best form, the cream is the most user friendly of all the ways progesterone can be given. Oral is generally a waste of time as 80-90% is destroyed as it passes through the gut and the liver and the dose has to be high which causes drowsiness. Injections are very painful, buccal/sublingual drops or troches are very bitter and suppositories are not much fun. The other advantage to the cream is it can be applied anywhere, in the vagina or nose for dryness, on piles, painful or achy areas, the best thing for burns and wounds, wonderful on the face, anti ageing too.

Please see the following papers:

Paper 1

Paper 2

Paper 3

Take care Wray

Jan 23, 2009
How Did You Do It?
by: claudine

Hi Wray

I just placed my first order and can't wait to start on the road to relief. If this works, I will be eternally grateful!

I am curious that it's impossible to find this type of product in OTC. Every pharmacy advised me that it's by prescription only yet a few clicks online and some dogged research and I have what I was looking for.

What is the reason for this? Just curious whether it's the pharmacuetical companies and the FDA bringing down the hammer again....

Share your thoughts?

Warm Regards,


Dec 09, 2016
by: Anonymous

How long did it take before it started to work and you felt better?

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