by Noelle

Hi there,

I will be using progesterone cream (2%)for the first time this month. I have endometriosis and have been struggling to fall pregnant for the past 5 years. I also suffer on and off from pretty shitty anxiety.

I have been told to use the cream in the morning an evening from roughly day 12-14. I have had anxiety around using the cream after readying many stories of peoples experiences/side effects etc.

How will I know if the 2% dosage morning and night is enough for me to keep estrogen dominance symptoms at bay? is it a case of trial and error? are there any other things I can be doing to eliminate the side effects? I am particular concerned with the weight gain. What will be the initial symptoms (if any) which will indicate I have estrogen dominance and in turn will require me to increase my dose?

Any help would be appreciated.

Thank you!


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Mar 12, 2021
Progesterone Newbie
by: Joy

Hi Noelle

Please consider using a 3% organic cream such as Natpro. You will have to use a lot more cream if using a 2% one and benefits will take longer. Usually between 100-200mg is needed using a 3% cream, more if symptoms are severe. Use half the amount in the morning and the other at night. The How to use Progesterone Cream page will explain in more detail. It will also explain when to use the cream i.e. on which days.

If you have a regular cycle with no problems, then use the cream by following your cycle, your luteal phase. If you do have problems with your cycle, then use the cream every day with no breaks until your cycle returns to normal and you feel stable. Then use by following your cycle. Things often get worse before they get better when first using progesterone, so time and patience is needed. Some gain weight, others don't. If not enough progesterone is used it will make matters worse. Every women is different, they will experience different things when first using it. You will have to experiment with progesterone therapy. If we do not supplement with progesterone, then we are more than likely suffer from Estrogen Dominance.

You might also like to read the Pregnancy page.

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