Progesterone for ADHD

by Mary

Hello, I have a friend that has a 14 year old boy with ADHD. Do you have any information on the use of progesterone cream for this condition?
Thank you

Comments for Progesterone for ADHD

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Jan 03, 2008
by: Anonymous

I too have a boy who has so called "adhd". We have been down the road of many medications and then come back to none, using only now natural remedies like fish oil, magnesium, zinc and a very natural diet.

Would love to know if Progesterone can be used to help with behaviour issues etc. I noticed that your webpage covers aggressive behaviour but what about concentration issues. Look forward to hearing from you. Kind regards. Maz.

Jan 06, 2008
by: Wray

There has been no definitive study on the possible affect progesterone might have on someone with ADHD. But there are plenty of research papers showing it's interaction between the serotonin, dopamine and GABA pathways. These are three of our most important neurotransmitters.

Amongst other things serotonin raises mood and lowers anxiety, dopamine helps memory and attention, helping us to focus, GABA is our major calming neurotransmitter, a low level causing anxiety and panic. Progesterone raises levels of all three, it also activates the GABA receptor sites, so using the two together is even more affective for calming.

Using a gonadotrophin-releasing hormone agonist (GnRHa) in early pregnancy has been found to cause ADHD in the child. A low level of omega 3 fatty acids during pregnancy is also implicated. Children with ADHD have been found to have low levels of the omega three essential fatty acids. In fact studies have found that animals and humans deprived of omega 3 have similar symptoms. If a new born comes in contact with the endocrine disruptor, bisphenol A, it disrupts the dopamine pathway resulting in hyperactivity.

Although the jury is still out, many papers are suggesting that the disruption of the dopamine pathway results in ADHD. Others that a low level of pregnenolone (the precursor to progesterone and DHEA) and DHEA and DHEAS results in ADHD.

I would suggest he tries 1ml/day (33.3mg progesterone) of the cream, plus 500mg/day L-tyrosine (the precursor to dopamine), increasing this gradually if no effect is found, 100mg/day DHEA, Omega 3 fish oil giving 1500mg EPA and 1000mg DHA per day, a good vitamin B and antioxidant complex.
Hope this helps Take care Wray

Physiology & Behavior
Motor inhibitory role of dopamine D1 receptors: Implications for ADHD

Nutritional Neuroscience
Increased Levels of Ethane, A Non-invasive Marker of n-3 Fatty Acid Oxidation, in Breath of Children with Attention Deficit Hyperactivity Disorder

American Journal of Clinical Nutrition
Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder

The International Journal of Neuropsychopharmacology
Analysis of neurosteroid levels in attention deficit hyperactivity disorder

LE Magazine February
A New Therapeutic Option for Behavioral Disorders

Jan 07, 2008
ADHD and progesterone
by: Wray

Hi Maz, Do hope the info I gave Mary is of help too. Take care Wray

Jan 13, 2010
by: Anonymous

I used progesterone cream in small doses on both my 16 year old son and 13 year old daughter after reading Dr Platt's book. All I can say is that teachers who had no idea I was trying it asked my daughter if she was being paid to be good! Even her school report mentioned that her behaviour had improved. Dr Platt says to use higher doses in his book but I'm a little nervous to. I guess you can only try it for yourself and see what happens.

Jan 22, 2015
ADHDi in teenage daughter
by: Rebecca

My 17-yr-old daughter suffers from severe symptoms of ADHDi (inattentive). She is basically failing in school. She is more than a year behind in some subjects. This has been her worst year yet. I am in the process of getting her tested and I presume it will result in her being prescribed medication. I just got to wondering about the possibility of there being a connection between hormones and ADHD. My daughter is very sluggish, overweight, extremely irregular with her periods, and at times very irritable. The problems with her periods make me think that her hormones are out of kilter, and hence, I started wondering if there is a connection between her other problems and her ADHDi. Would it be advisable to start giving her some Progesterone Cream? And how much should I give her and how would we follow her cycle, being she is so irregular?

Jan 23, 2015
ADHDi in teenage daughter
by: Wray

Hi Rebecca You could well be right. In fact it sounds as if your daughter could have PCOS. Please look through this page, in particular the list of possible symptoms. It does give amounts of progesterone to use, and how to use it. To begin with use it daily, ignoring any bleeding. Do this for at least 3 months or more, then the progesterone can be used to start a cycle going again. I would also suggest giving her tyrosine too, this is the precursor to dopamine, our get up and go neurotransmitter. Start off low on say 250mg/day and increase slowly till you find the optimum level. Please have her Vitamin D levels checked too, all too often this is low and it can have an effect on how our brain functions. Plus a low level adversely affects progesterone. Take care Wray

Aug 27, 2015
progesterne in pregnancy
by: Anonymous


I am pregnant and because I had an abortion last year my doctor prescribed about 10 progesterone injection for me. And I am feeling his movements since 18 weeks. I wonder if they may cause hyperactivity in my child. please inform me if you have any experience.

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