I am currently using prog./test./0.15 mg/0.1 ml cream twice daily prescribed by my Dr. and comes from a compounding pharm. I read your articles which states that we probably need 100/200mg daily to be effective. I mentioned this to my Dr. and she said you were probably quoting the dosage used in pill form (which my body won't tolerate), that the cream was much more condensed (for lack of a better word) and all of it gets into my system much quicker as opposed to the pill which has to go thru quite a process to be absorbed in the body and in which case we loose a lot of the effectiveness of the meds. Can you let me know if this is the case, I have been using this for about 6 months and feel no difference in my symptoms except some weight gain (which is impossible to loose). I took the Saliva test and was told my estrogen was extremely high. I am almost 68 yrs. old and definitly thru menopause. I am also using Estriol,1mg daily for vaginal dryness and something called Vulvodinia. Nothing seems to help. Your advise please.