Progesterone cream has been curing chronic fatigue... now suddenly stopped working
I have been bed/housebound with severe chronic fatigue for 15 months, Jan 17 to present.
It started in Jan 2017, I had been taking progesterone only pill for 16 months since the birth of my first child, this had also been a period of intense stress and only 3 hrs sleep a night. 2 weeks after stopping the pill in Jan 17, I suddenly could not walk, barely talk, watch TV, etc.
I first tried Natpro cream last summer for 2 months, Jul & Aug 17, 50-200mg daily, my condition improved steadily each day. I continued to have periods during this time, and kept a note of how I felt depending on time of month. I improved more when estrogen would be low and not much (or slight regression) during the two times of month when estrogen peaks. Overall I experienced a dramatic improvement in my condition. Then I stopped using the cream as my husband wasn't happy me using it without doctor supervision and within 2-3 weeks of discontinuation I was bedbound again.
I have been using Natpro progesterone cream again since Nov 17, generally 250mg per day, from being bedbound in dark room 23/24 hrs a day unable to speak, I got a tiny bit better each day, never worse. The more I took, the better I got. On the odd days that I took 400mg cream I improved twice as fast. From Nov '17 I have not had monthly bleeds so have no idea what my 'cycle' is doing. I still feel I have times when estrogen rises, as significantly less daily improvement is observable.
Now suddenly for the past month the progesterone cream has stopped working completely, absolutely no daily improvement, and in the past month I have had two times when my condition has worsened (each time a step change from which I have not recovered), I presume due to estrogen rising. I've also noticed my hair is greasier.
I have read that after several months of use the cream can stop working, due to downregulated receptors (I've taken no breaks), or your body thinking it has enough and converting to estrogen/testosterone, or dermal fatigue (I've been trying inserting to vagina with syringe for past couple of weeks, but it's not made any difference).
Any ideas? I'm desperate. I know if I go off the cream I will go back to being bedbound, this has happened to me before as I also took cream last summer for 2 months, improved each day, stoppped using it and within weeks was bedbound again. It has taken me so long to get this far with tiny daily improvements, I cannot lose all that ground.
However, I don't want to increase again and mess up all my other hormones. My husband and mother are dead set against me taking more so it's really not an option.
I cut out all estrogens, phyto estrogens, xeno estrogens, etc. in the autumn, could it be that these were actually protecting me against estradiol? See the summary of this research indicating that estradiol inhibits the production of ATP (cellular energy) which is obviously what CFS sufferers lack: https://www.ncbi.nlm.nih.gov/pubmed/12587531