Progesterone and Psoriasis

by Pam

I have psoriasis and just read on a web site that progesterone can cause the psoriasis to get worse.

I am a bit confused because I read on your web site that progesterone cream may help psoriasis. I just ordered more progesterone cream and now I am wondering. I don't want to use something that will make the psoriasis worse. What is your opinion on this?

Comments for Progesterone and Psoriasis

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Jun 09, 2011
Progesterone and Psoriasis
by: Wray

Hi Pam I've not heard that progesterone can cause a worsening of psoriasis. Most probably the amount used was too low. This almost always has an adverse effect, as progesterone initially stimulates oestrogen. This is an inflammatory hormone, plus it stimulates mitosis and cell proliferation. Psoriasis is often induced by stress and as progesterone is excellent at calming us, it seems unlikely progesterone would make it worse. Plus progesterone inhibits mitosis, and induces apoptosis. I have helped people who've used progesterone and had success too. But I believe you are short of vitamin D, see here, here, here, here, here,here and here.

Interestingly, progesterone and vitamin D work together, a lack of vitamin D reducing the benefits of progesterone. The skin comprises 95% kerotinocytes, these have ample receptors for both progesterone and vitamin D. In all the studies above, calcitriol was used, this is the hormone that D3 is converted to. But calcitriol also needs D3 to work effectively, so to my mind a combo would be of more benefit. Please have a vitamin D test done, for more info on testing see the Vitamin D council and Grassroots Health websites. If you should continue using the progesterone, please use sufficient. I recommend 100-200mg/day, dependant on symptoms. I don't know how much you've been using, but if it's the typical 20-40mg/day, please read our page on Oestrogen Dominance before increasing it.
Take care

Jul 05, 2017
Progesterone Dosage
by: Kim

What dosage of Progesterone would you recommend for someone like me who is post menopausal and struggling with the discomforts of psoriasis?

I have tried micronized progesterone in the capsule form, but am unable to tolerate it well since I end up making a vast number of trips to the bathroom at night. In addition, the 200 mg capsules didn't relieve my psoriasis. I have tried the 50 mg vaginal suppositories and they don't send me to the bathroom, but are not of a high enough dosage to fully correct the itchy rash across my back, though I did notice some relief. My doctor has informed me that I don't have enough receptors to use the cream form of progesterone since it stopped working a while back. Please advise...

Thanks, Kim

Jul 06, 2017
Progesterone Dosage
by: Joy

Hi Kim

I suggest starting with 200mg Natpro Progesterone cream per day and see how you get on with that. You may need more, you will have to experiment with this amount. You would be wasting your time and money with the capsules or any form of oral progesterone as 96% gets destroyed by the gut and liver. It doesn't surprise me that you didn't find relief.

Rubbing Natpro on the affect areas may also help. Suppositories are good but rather messy, should be used at night only and get into bed. But 50mg is not nearly enough. Progesterone should be used no less that twice a day.

What utter nonsense is your doctor telling you? How bizarre! This is not the case at all, you clearly have not been advised on the correct use, dose or delivery method.

Please take note on what Wray advised Pam in the above post. Vitamin D3 is vital, read up on the info given.

Please read the following pages and the references:

How to use Progesterone Cream

Estrogen Dominance

Vitamin D3


Delivery Methods

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