Progesterone and Graves Disease/Hyperthyroid

by Deb
(Charlotte, NC)

Hello-I was wondering if you could give me some information about how progesterone would affect my condition of Graves Disease, which is hyperthyroid. I started taking a natural progesterone cream about 4 days ago and it is making my hyperthyroid symptoms worse. I have read that this is because progesterone wakes up they thyroid receptors, making thyroid hormone work better. Well, already having too much because of the autoimmune disease, I think that it is making my condition worse. Have you heard of anyone who has this condition successfully taking progesterone? Is this side effect only temporary or permanent? I am 43 years old and have had horrible PMS since the Graves disease and I am fairly certain that my progesterone is low. I have started having night sweats and feeling hot, as well as hair falling out, facial hair on chin and heart palpitations. Please let me know if the higher thyroid function is temporary and if it will make my autoimmune thyroid condition better or worse?

Comments for Progesterone and Graves Disease/Hyperthyroid

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Oct 08, 2013
Could be me too.
by: Jo

Am interested in this query and response. Please keep me in the loop. Thanks.

Oct 10, 2013
Progesterone and Graves Disease/Hyperthyroid
by: Wray

HI Deb I would ask you to have a vitamin D test done, all autoimmune diseases have a low level. I feel one day they will realise they are nothing more than a vitamin D deficiency disease, see here, here, here, here, here, here and here. Progesterone won't make it worse, but it seems you are probably using a small amount. This stimulates oestrogen leading to an Oestrogen Dominant state. The night sweats and Hot Flushes are explained on this page. Excess testosterone causes hair loss and facial hair. Oestrogen causes prolongation of the QT interval, which results in palpitations, arrhythmia, Torsades de Pointes and sudden death. Whereas progesterone shortens the QT interval, see here, here, here, here, here, here, here, here, here and here. Continued below

Oct 10, 2013
Progesterone and Graves Disease/Hyperthyroid Part 2
by: Wray

Hi Deb These symptoms occur far more frequently in women who naturally have a long QT interval, rather than men who naturally have a short QT interval. A lack of vitamin D reduces the benefits of progesterone, please have a test done. Once you know your level you will know how much to take to get it high. We do have two pages you could look through, How to use progesterone cream and Peri-menopause. Take care Wray

Nov 25, 2014
also wondering
by: Anonymous

My first bout of graves disease was triggered by pregnancy and I am pretty sure my second bout (I was back to normal) was triggered from using natural progesterone cream.

I don't know the logistics of why but it coincided timings wise. I have a very healthy vitamin D level as I had that and my iron both tested. So it's not that.

Jan 01, 2018
High Progesterone Hyperthyroid Link
by: Anonymous

Thanks for the experiences shared on this thread. I know it’s about 4 years old, but it’s relevant to me today as I’ve developed hyperthyroid. Thankfully I made the link that I’ve been using OTC progesterone cream over the last 6 years- unnecessarily I now realize as my levels were never tested.
Current blood tests show high progesterone levels and hyperthyroid. Coincidence? I think not.
Anybody know of good ways to detox from progesterone? It stores heavily in fat, so it may just be a time factor. It makes sense that hyperthyroid develops to rev up the metabolism.
Anyone have experience with this?

Feb 21, 2018
Hyperthyroid and low pg
by: Phoebe

I had mild hyperthyroid and almost nonexistent progesterone. I think progesterone and a lack of it affects each woman differently.

For me progesterone cream was the answer to almost everything.

Feb 22, 2018
Hyperthyroid and low pg
by: Joy

Hi Phoebe

I am so pleased that progesterone helped you. If used correctly it can help with so many adverse symptoms. A Vitamin D3 deficiency also affects the thyroid.

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