Prempro prescribed/have questions

by Anita

I have recently been prescribed Prempro 0.625MG/2.5MG. My symptoms are the typical listed for progesterone deficiency. I had a complete hysterectomy at age 37, am now 54. My main concern is weight gain around the middle. After researching Prempro I'm not sure it is right for me. Is it typically prescribed to someone without a uterus? Will it help to alleviate the progesterone deficiency symptoms I am experiencing? Would I be better off using a progesterone cream?

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Aug 06, 2012
Prempro prescribed/have questions
by: Wray

Hi Anita Prempro is normally given to women with a uterus, evidently your doctor thought the progestin it contains would increase your progesterone level. So strange how they think it will, even stranger is the ignorance behind progesterone and the progestins. One all important fact which is never taken into account, the progestins are not metabolised into the progesterone metabolites. Some of which are more important than progesterone itself. We do have a page on HRT with more info. The weight gain around the middle is caused by excess testosterone, see here and here. If bound to SHBG (sex hormone binding globulin) testosterone becomes inactive, progesterone raises levels of SHBG, see here, so preventing the rise of free testosterone. SHBG drops if sugars are eaten, even those found in all grains, legumes, dairy and sweet starchy fruits and vegetables. Fructose, sucrose and glucose, reduce SHBG by 80, 50 and 40% respectively, see here. It's best to avoid all the foods and sugars mentioned. I feel you would be better off using progesterone. We have more info about it on our Menopause page. But before considering it please see our page on Oestrogen Dominance first. Take care Wray

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