POF- premature ovarian failure, premature menospause

by dubravka
(prague, czech republic)

Hi, I am 40 years old, at age 33 I was diagnosed with POF, premature ovarian failure. Last 4 year I was on HRT 1mg estrofem E2 (from day 5-till 26) and utrogestan 100mg (from day 14-til 26). I do not feel ok, It helps me to not have intense hot flashes but I was dealing with frequent insomnia and other bad symptoms. So now I decide to take natural progest cream instead of utrogestan and low the dose of E2 to half. I take around 80g per day from day 7 progest cream and I can already see improving in sleeping but I got erlier menstruation and headache and burning leg at night and very cold during the day and I feel a lot of frustration and irritation in lower belly, together with weakness, and I am craving food all the time.

I would like ask for advice. What would u do in my position, increase progest cream and continue with same dose of E2? What is your suggestions?

Thank you for your advice or expirence sharing.

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Jul 07, 2018
POF- premature ovarian failure, premature menopause
by: Joy

Hi dubravka

If you read this website you will see that taking extra estrogen is not advised. It adds to Estrogen Dominance symptoms. There are well over 100 estrogen mimics in our Environment as it is, why take more? You are not using enough progesterone, 100-200mg is needed. It can take 2-6 months for the body to adjust. Please read How to use Progesterone Cream. I suggest that you use progesterone only and see if that will help you. Use every day until a regular cycle returns. Once it does, then use the cream at your luteal phase as explained on the How to use Progesterone Cream page.

Food cravings could be an Insulin Resistance problem, have you been tested? This usually occurs around Peri-Menopause and Menopause, it does not affect all women though.

Vitamin D3 is very important as a deficiency reduces the benefits of progesterone, optimal range is between 70-100ng/mL. Nothing less than 5,000iu's is needed daily. Co-factors are needed when taking D3, magnesium and vitamin K2 with no soy are the important ones.

Jul 08, 2018
by: dubravka

Joy, thank you very much for your answer. You cannot imagine how intense struggle I have with my hormone last 20 years. Doc. put me on BC pill when I was 19 years, because I bleed a lot. I was 5 years on that pill, then have enough and stop to take it because I have big headache. Very short time after that start long "rock and roll".

I had menstruation very often every 18-23 days, very heavy bleeding couple years and then I start to have high FSH, more than 50 an LH also more than 50 at age 34. I got diagnose POF. I try everything, herbs and acupuncture and nothing helps. Here in Europe, in Czech Republic you do not have progesterone cream.
So I was literally exhausted on any level. I do have insomnia, hot flashes and lost 25kg because I losing a lot of water, I had pee all the time. So I finished on HRT, estradiol and Utorgestan, and that helps me with hot flashes and with loosing huge amount of water trough peeing. But insomnia and frustration irritation in body continue, mood change, sadness and all that weakness packing, big hole. My life become prison.

Before couple month friends bring me from US Progest cream Emerita , 5 tubes.
So here I am now, I stop using utrogestan vaginally and take progest cream every day with estradiol, very low dose. First month I start using Emerita instead of utregestan, 14day of cycle and I got premature bleeding after 10 days. Than second month I start using progest cream from day 3 after bleeding, little bite calm down but with it I take half dose of estradiol and I use it vaginally, because I have vaginal dryness. I start to have bleeding very intense day 23. Now what?

You suggest to stop with eastradiol completely and use cream every day 100-200mg? Should I gradually take off estradiol or just finish with it? I am just afraid of vaginal atrophy and hot flash will arise after bleeding stop.

I do take D3 but I will rise dose, I was taking less than you recommend and I will take vitamin K, I do take magnesium. My insulin's is fine for now, I am craving food couple days before bleeding start and in the same time a I have headache.

Is it possible that women who have been diagnosed with POF premature ovarian failure can use only progesterone without eastradiol at least bio-eastradil?
Do you have any example, some story that some woman with POF manage her symptom only with progest cream. And I also would like to have children when I regulate cycle and my health, that desire is still strong in me. I do not have any.

I am just looking for support and guidance.
And I am so grateful that I find your website and such a valuable information. Thank from the bottom of my heart for guidance.

Jul 08, 2018
by: Anonymous

The second month on progesterone cream it is create such intense bleeding that I can not generaly stand up from bed, I am losing so much blood. The first month is was also strong, so scary, I feel very weak and faint. Today is second day and because is so intense I take cream again already cca 100mg in the mornng, will use again at night.

I hope so I am doing right step? First plan was to use cream after menstruation 8 day, Any advice?

Jul 10, 2018
by: Joy

Hi dubravka and Anonymous

The cream that you are using is not strong enough, it has 900mg of progesterone, whereas Natpro has 3,333mg per 100grams of cream which is a concentration of 3.33%. You will need to double the amount that you use. Progesterone cream is excellent when inserted in the vagina at night, it will help with the dryness.

This protocol does help with heavy/continual bleeding.

* 400-500mg Natpro Progesterone Cream per day
* 2000mg N-Acetyl-Cysteine (NAC) per day
* 2000mg Taurine per day
* 5000iu's Vitamin D per day - more if deficient
* 1000mg Bioflavanoids per day

This is the best way to wean off Estrogen/HRT

Anonymous, please read advice given to dubravka.

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