by Denise

I’ve not been on this site for few years but have been using progesterone cream for 16 years 300 to 500 mg a day with very few breaks along with 5000 to 10,000 vit d transdermal magnesium magnesium glycinate. Recently I started using NAC for sinus issues but started to feel not so good I thought maybe it was detox but after googling NAC and estrogen I found some info on pubmed that states NAC increases estrogen I know Wray referred to pubmed a lot and I’m hoping this is not the case any bodies thoughts on this appreciated thankyou

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Jun 11, 2024
by: Joy

Hi Denise

Welcome back to the website.

I am pleased that you are taking vitamin D3 and magnesium. Any reason why you are not taking the other cofactors which should be taken when taking D? Magnesium and vitamin K2 being the most important. Vitamin D3 helps the body absorb calcium from the diet. Vitamin K2 directs the body to deposit the calcium in the places where it is needed, such as bones and teeth and NOT in organs, arteries, muscles and soft tissue where it can cause health issues. It is Magnesium's job to keep it where it belongs.

How much NAC did you start with? Sometimes one needs to start on a low amount and work up. NAC as you probably know burns fat and builds muscle. A powerful antioxidant and free radical scavenger, it boosts the immune system, energy and metabolism. A precursor to glutathione, itself a powerful detoxifier of the liver. Selenium, zinc and cysteine deficiency result in reduced levels of glutathione. An anti-aging amino, reduces age spots, also used in the treatment of rheumatoid arthritis, cancer, burns and wounds. Lowers homocysteine, strengthens skin, nails and hair, chelates heavy metals including mercury and lead, a hangover remedy. Breaks down mucus so used in bronchitis, emphysema, tuberculosis and cystic fibrosis. It has been used as a mucolytic agent in chronic respiratory illnesses as well as an antidote for hepatotoxicity due to acetaminophen overdose. More recently, animal and human studies of NAC have shown it to be a powerful antioxidant as mentioned and a potential therapeutic agent in the treatment of cancer, heart disease, HIV infection, heavy metal toxicity, and other diseases characterized by free radical, oxidant damage. NAC has also been shown to be of some value in treating Sjogren's syndrome, smoking cessation, influenza, hepatitis C, and myoclonus epilepsy.

It is for these reasons that Wray recommended it highly. She took high doses, I take 500mg per day. Our food has so many estrogenic properties as well. I feel more than likely you were detoxing. Please read these pages, Wray explains a little more about NAC see here and here.

Regarding NAC increasing estrogen, see this PubMed article but I am not altogether convinced about the test. This article seems to conflict.

May I suggest that you stop taking NAC, wait for a week and start again a small amount and take it from there.

Best wishes.

Jun 11, 2024
by: Anonymous

Thankyou for getting back to me so quickly and yes I do take k2 and magnesium oral and transdermal along with the 10,000 transdermal vit d3 thankyou. The link on pubmed you sent was the one that I was reading before I contacted you which concerned me because I worked so hard to balance my hormones I’m now 61 post menopause 11 years but what I will do is stop the NAC for a week and start again with one 600mg capsule by the way it has added selenium in it Thankyou for your kind advice

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