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Miss

by Callie
(Athens )

Hi everyone.
I just needed some thoughts or ideas so I decided to post here.
First of all this website has so much information and I am grateful for that.

I started applying a progesterone cream on thin skin areas since Feb 2025 such as behind knees, top of my feet, inner arms, top of my chest. I hadn't had a period for nearly 12 months (I started using it as I'm very estrogen dominant).
Then I saw on the website that we can use it anywhere pretty much as it will get absorbed.
I started using it on my thighs, calves, inner arms etc and it feels like some of my symptoms came back. Initially I said to give it time cause it might be recalibrating. Then I just got my period.

The reason I stopped using thin skin areas is that my joints were becoming way to loose in sensation since I also suffer with hypermobility in my joints.
It's been 7 days of bleeding and then spotting so I am not sure if I should up the dose or wait it out.
I am worried of applying it back to thin skin areas as it caused me issues.

Has this happened to any of you?

Comments for Miss

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Jan 29, 2026
 Miss
by: Joy

Hi Callie

Thank you for your kind words about the website.

You don’t state how much progesterone you are currently using. Generally, a dose of 100–200mg per day is recommended, sometimes more if symptoms are severe. Once any adverse symptoms have settled, the amount of cream can usually be reduced.

Using a good-quality organic progesterone cream, such as Natpro (a 3% cream), should be very helpful. Please also read the How to Use Progesterone Cream page, as this is important for best results.

A missed period for 12 consecutive months places you in Menopause. Given that you mentioned you’ve been using progesterone for almost 12 months, I suspect you are now at the end of Peri-Menopause.

There are many Misconceptions about progesterone use. Applying it only to thin or layered skin is one of them. The cream can be used all over the body, and inserting a small amount vaginally at night can be very helpful for dryness or any irritation that may be present. Progesterone is also absorbed through hair follicles. You can also apply it to your face. There are many suitable application sites.

Your body is still adjusting to hormonal changes. Knowing the exact amount of cream you’re using would help, but I suggest increasing the amount for now and observing how you feel. I also recommend using the cream daily, without breaks.

What your Vitamin D3 level is? A deficiency can significantly reduce the benefits of progesterone. Vitamin D3 is involved in nearly every cellular function in the body, making it vital — including for hypermobility, where it can help support the condition. Please note that co-factors are important when supplementing with vitamin D3.

Kind regards
Joy

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