I'm a 40 year old woman who was diagnosed with lupus sle 3 years ago. Once the medication I was put on had started to work, I was relatively symptom free for about 2 years, but the past few months the symptoms are starting to return. My mum has strongly recommended that I use progesterone cream as it worked for her with her osteoporosis. I'm very nervous about trying this as I know that the hormone oestrogen can aggravate my symptoms. I wondered if there is any evidence that progesterone cream could help with my symptoms?