by Liz

I am currently using Wellsprings Serenity progesterone cream and would like to switch to yours, mainly due to the fact that I have found so much helpful information on your site. I can't find the percentage of active ingredient anywhere for Wellsprings' cream and would like to know what will happen if I switch. Is yours stronger or weaker? Do I use more or less? Will my endometriotis react to the change?

I'm currently using about twice recommended (I'm using a little finger tip three times a day), in an effort to stop what I think is chronic endometriotis pain.

I can get no answers from the medical profession and just want the pain to stop so am trying everything. Although I am 53 and have gone / going through menopause for the last ten years, I can guess at nothing else. I've been treated for several other things and none of those treatments have worked..


Comments for Liz

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Feb 11, 2013
by: Wray

Hi Liz Thanks for the kind words about the site. Serenity contains 21mg/g of cream. The Natpro contains 33.3mg/g, so it's almost 40% stronger. It's difficult to judge what a 'finger tip' is! I have found for the pain of endo that 500mg/day is needed. We do have a page on Endometriosis you could look through. It's caused by oxidative stress, so large amounts of antioxidants are needed. NAC (N-acetyl cysteine) is an essential one, plus trying to reduce stress, as that exacerbates it. The progesterone will help with this, as it lessens the stress response. Please have a vitamin D test done too, it could be your level is low. For more info on vitamin D levels, test kits etc see the Vitamin D Council, GrassrootsHealth and Birmingham Hospital. Blood levels should be 70-100ng/ml (175-250nmol/L) and not the 30ng/ml (75nmol/L) most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although recent research indicates it should be 10,000iu's per day, see here. Vitamin D is a potent antioxidant, anti-inflammatory and also an analgesic. Unfortunately, Peri-menopause is such a difficult time, with dropping progesterone levels and normal oestrogen. This is an excitatory, inflammatory hormone, so exacerbates endo. It increases free radicals, hence the need for the antioxidants. Oestrogen stimulates glutamate, our most excitatory neurotransmitter, see here. Whereas progesterone protects against glutamate toxicity, it also increases BDNF (brain-derived neuroptrophic factor) in itself protective, see here and here. There's more info on our page How to use progesterone cream. Take care Wray

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