by Kathy

I’ve started using bio identical progesterone pills and worked my way up to 800mg. 200 morning, 200 lunchtime and 400 before bed. I don’t have very high estrogen levels really but no progesterone.

My ratio was under 100.

I’ve found when I take the progesterone which I do vaginally I get a long hot flush or hot sweats about half an hour later. I’ve been using it for 3 weeks now. Is this normal in initial stages?

I’m also waking with a sense of dread in my chest which feels awful. I can also get it after taking a dose in the afternoon at times.

Comments for Kathy

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Jun 15, 2024
by: Joy

Hi Kathy

As you have most probably read on this website, any kind of oral progesterone is not the best Delivery Method as around 96% gets destroyed by the gut and liver see here. However you have used the pills vaginally so that would make a difference. Please consider using a good quality natural cream such as Natpro but see how you get on with the pills.

Progesterone therapy is not an overnight fix, it can take 2-6 months before positive results are felt. What you are experiencing is normal as your body adjusts. If the pills are not strong enough this will aggravate your estrogen receptors and things will take longer. Please read the How to use Progesterone Cream and Estrogen Dominance pages.

It is a pity that you didn't give your rest results as to say that your estrogen level isn't high means nothing to me. It is the ratio between progesterone:estrogen that is important. You say your ratio is 100. It should be 600:1. Please read the Hormone Testing page.

What is your Vitamin D3 level? I am asking because a deficiency will reduce the benefits of progesterone. It is also connected to every single functioning cell in our bodies making it vita. Cofactors, name magnesium and vitamin K2 are equally important.

Jun 16, 2024
by: Kathy

Thankyou joy.

My estrogen result was 27pmol and my progesterone whilst on progesterone therapy was 91 so I’m definitely absorbing it.

If my estrogen receptors are being triggered can this happen very soon after a dose? I can insert my progesterone and about half an hour later can get really irritable and aggressive. Can it happen this soon after a dose?

Generally I’m having a really hard time and can’t see how I can just ride it out for 2-6 months.

Are these normal estrogenic effects:

Hot sweats and flushes
Dread in my chest
Waking up with palpitations and dread
Memory issues
Brain fog
Increased histamine issues

Thanks xx

Jun 17, 2024
by: Joy

Hi Kathy

I take it these of blood tests?  In which case your progesterone:estrogen is 3:1.  It should be 600:1 as per the Hormone Testing page given to you. If saliva tests I get 3370:1 Can you confirm what tests you had.  Or you can work the ratio out yourself. 

As we are all different, we all react differently to progesterone therapy, whether used once or not.  So I am not surprised that you reacted the way you did.  Progesterone therapy is not an overnight fix either.  It takes time as mentioned.
You very clearly are suffering from estrogen dominance.  You can overcome the adverse feelings that you are experiencing quicker by using more progesterone.  For you, I suggest 400mg progesterone cream.  Once you feel stable you can slowly start to reduce the amount to a level that suits you. This is something that you will have to experiment with.

You might want to try taking some of the calming nutrients mentioned on the Anxiety page.

Regarding your histamine issues.  It would appear that you have an Inflammation issue.  Allergies to certain foods. Estrogen increases the response to allergens, progesterone inhibits mast cells, responsible for the increase in histamine.  You might want to read the inflammation page and address your gut issues.  Fermented foods are excellent for this, they are the best probiotics one can get.  Better than the OTC ones.

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