Is it safe to use Duphaston?

by Chinni

Hi Wray
Iam 9th of pregnant now and this is my first pregnancy.From 4th wk my Doc adviced to take Progesterone 200 mg till 8th wk.After 8 wks i went to check up..Baby hear beat is fine.Again my doctor adviced me take Duphaston 10 mg twice daily for 1 month.Is it safe to use ?
Please Advice.

Comments for Is it safe to use Duphaston?

Click here to add your own comments

Apr 17, 2012
Is it safe to use Duphaston?
by: Wray

Hi Chinni Progesterone is excellent, but I would never recommend Duphaston. It contains dydrogesterone, a synthetic progestin. But because it's a progestin, it's not broken down into the normal progesterone metabolites. This is something which is never taken into account by doctors prescribing progestins. The metabolites are as important as progesterone itself. In particular allopregnanolone, a potent analgesic, anti-inflammatory and anxiolytic. For more info on progestins see here.
(Scroll down to the second link on Google to see the full pdf article entitled "Classification and pharmacology of progestins"). There is a section on dydrogesterone. We do have a page on Pregnancy you can look through, plus this one here. Another progestin they might offer is 17 OHP caproate (17-OHP C), often given for pregnancy problems. I would always favour the use of progesterone. There is no evidence to date of any adverse side effects to the foetus while using progesterone during pregnancy, and it's more potent that 17-OHP-C, which also has safety concerns about it's use, see here. I can never understand why they don't just stick with progesterone, it's cheap and readily available. But more importantly there's no risk to the foetus. Take care Wray

Click here to add your own comments

Join in and write your own page! It's easy to do. How? Simply click here to return to Progesterone faq.

Share this page:
Find this page helpful? Please tell others. Here's how...

Would you prefer to share this page with others by linking to it?

  1. Click on the HTML link code below.
  2. Copy and paste it, adding a note of your own, into your blog, a Web page, forums, a blog comment, your Facebook account, or anywhere that someone would find this page valuable.

Search over 8,400 pages on this site...