I'm confused how much progesterone to try, regular cycles but perimeno?

by 45YOWoman

I'm 45 with adnemyosis, thickening of the uterus. I gained weight this year and cannot lose, anxiety, hair loss. I cannot figure out if I do the day 8 to my period of application or if I do "all month long" with no breaks. I have regular periods, every 28 to 30ish days, sometimes they do seem "earlier" than they should. I have very heavy periods with lots of fatigue/sleepiness and (the heavy periods lasts 4 days, my periods lasts a normal 6,7 days), and uterine cramps/back aches.

Am I considered perimenopause and I take it all month long. Try 100 to 200 per day (in two doses) or the higher dose for my condition. I need relief, as I am considering a hysterectomy and I know that will just cause more hormonal imbalance sigh.

Comments for I'm confused how much progesterone to try, regular cycles but perimeno?

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Mar 12, 2021
I'm confused how much progesterone to try, regular cycles but perimeno?
by: Joy

Hi there

You are in Peri-Menopause as you know. It can be a challenging time for most women. The monthly cycle can become rather irregular so it is difficult to use the cream while following a cycle. For this reason I suggest using progesterone every day with no breaks. You say that you have a regular cycle, yet you also state that sometimes they seem to come earlier. This indicates to me that your cycle is not regular.

The thickening of the uterus is caused by estrogen build up. The correct use of progesterone will help to clear out the lining of the uterus, usually clotting will happen when this happens. Don't be alarmed, this is a good thing.

Usually between 100-200mg is needed using a 3% cream such as Natpro, more if symptoms are severe. Use half the amount in the morning and the other at night. The How to use Progesterone Cream page will explain in more detail. You will have to experiment with progesterone therapy to see what suits you best. Please also read the Estrogen Dominance page.

Please give progesterone a chance to work before you consider a hysterectomy, in most cases they really are not needed.

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