How long will a tube last?

by Jackie

I've been looking into buying natural progesterone cream and have noticed that a tube of Natpro lasts 1 month and the same amount of Wellsprings Serenity will last 2-3 months.

Can you tell me why that is as they are both similar prices? Also which one is the best? Thankyou for your help.

Comments for How long will a tube last?

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Jul 23, 2010
How long will a tube last?
by: Wray

Hi Jackie There is so much confusion about how to use progesterone. It should only be used according to symptoms and not by 'dose'. I have some women using 1 tube in 4 days their symptoms are so bad. This is 500mg/day progesterone. And yet others need less than one, and of course men will require only 1 tube in 3-6 months. The price is very different, as it's not a cream you are buying but progesterone. Serenity costs £17.99 or $27.42 and contains 1260mg progesterone, the Natpro is $23.00 and contains 2000mg. To get the equivalent amount of progesterone as Serenity it would cost $43.54. To help you decide which is best I've given the ingredients of each...

Serenity Ingredients: Deionised Water, Aloe Barbadensis Leaf Juice (Aloe Vera), Vegetable Oil, Glycerin, USA Produced USP Natural Progesterone (2.34%) USA, Isopropyl Myristate, Glyceryl Stearate SE, Cetyl Alcohol, PEG-20 Methyl Glucose Sesquistearate, Stearic Acid, Sodium Hyaluronate, Sodium PCA, d-alpha Tocopherol, Methyl Glucose Sesquistearate, Grapefruit Seed Extract, Xanthan Gum, Carbomer, GermabenII, AMP95. (Merest trace of commonly-used preservatives added due to the ineffectiveness of natural preservatives).
(Germaben II is a synthetic preservative and contains propylene glycol, propylparaben, methylparaben, and diazolidinyl urea)

Natpro Ingredients: De-ionised water, macadamia oil*, cetearyl olivate/sorbitan ovilvate*, progesterone 2000 mg, populus tremuloides*, dl-alpha tocopherol *natural or organic
Take care Wray

Jul 25, 2010
how much cream do i use after hysterectomy and one ovary
by: jackie

Hi Wray I have got a tube of Natpro but am unsure when to use it as I have had a hysterectomy and have one ovary. I think I still ovulate but am unsure, but have various pms symptoms but no periods to guide me on when to use the cream. Please could you guide me. Thank you.

Mar 03, 2011
stability of progesterone cream once opened
by: Laura

Hi Wray,
I started progesterone cream about 2.5 months ago for severe PMS and the first two cycles it worked wonderfully to combat fatigue, irritablity and low mood. This month it seems to be less less effective.

I am using the same squeeze tube I started with from Emerita following the same doses - I am wondering if the cream can become less effective if not used within a certain timeframe?

Also I live in a warm climate and am unsure if refrigerating the cream will harm it or assist with keeping it fresh?

Many thanks for your advice,


Mar 12, 2011
how much cream do i use after hysterectomy and one ovary
by: Wray

Hi Jackie I don't know how I missed this query of yours! If it's not too late, please see our page on Menopause. It explains how to use the cream if there's no cycle. Take care Wray

Mar 12, 2011
stability of progesterone cream once opened
by: Wray

Hi Laura I'm so pleased the progesterone helped you, but I'm amazed you didn't suffer Oestrogen Dominance when you first started it. The amount they recommend is far lower than I suggest, which is 100-200mg/day. Progesterone itself doesn't become less effective, even if the cream is past it's expiry date. This date is given as a precaution against the deterioration of the other ingredients. In a cream it's mainly the oil content which could go rancid if the antioxidant has worn out. Or if mould and bacteria have formed due to a loss in efficacy of the preservative. Have you had more stress than normal this month? Stress drops progesterone levels, so more is always needed to prevent symptoms returning. Progesterone should always be used as and when needed, so the amount can vary substantially from one day to the next, from one week to the next. It shouldn't be used as a 'dose'. For more info please see our page on How to use progesterone cream. I'm not sure about the cream you are using, but ours has suffered 40 degree C temps by being left in a letter box for 2 days in a desert in the States! And has been frozen solid, again in a letter box, during winter in Sweden with minus 30 degrees C! It still worked. So if you wish to refrigerate it by all means do so, it certainly won't harm it. Take care Wray

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