How did my Progesterone levels get so HIGH!
I am a 54 y/o postmenopausal female, 5'7", 150lbs with all organs intact.
4 years ago I began missing my period fro 3-4 mo in the fall of the year. I had my Vit D tested and it was 19 so I was treated with 50000units by an endocrinologist and it came up to 55. Since then I was taking 2000u a day, but my vitamin D dropped back down to 25, so now I am taking 5000u and my Vit D now stays around 45. I am taking D3 form.
During the times of missing periods I would have tremendous hot flashes, 30/day, insomnia, night sweats, and most bothersome of all...urogenital pain which was almost constant. When my periods resumed, these symptoms all went away. My Gyn refused giving me any hormones as I was still having occasional periods.
1 1/2 year ago I had my last period and these symptoms came back to stay. At first I was just given vaginal hormones which did not stop the urogenital symptoms but made them a little less intense, but did nothing for the other symptoms. My Gyn died, so I had to get a new one, and this one doesn't believe in systemic hormone therapy. So....I found an internal medicine doctor who works with a compounding pharmacy and PHARM D program through a university health system.
My baseline hormones (serum)
total estrogen 96 (E1+E2+E3) pg/ml
prog less than .5ng/ml
total testosterone 28ng/ml
All of these were in normal range for post menopausal female but I felt terrible.
The pharmacist calculated doses for me and I was put on a SL (sublingual) dosage as follows (splitting dose in am and pm) troche...
BIEST .5mg (70% estriol and 30% estradiol)
Still having urogenital problems 5 months later, although I had more energy and was sleeping better with great decrease in hot flashes. Still using vaginal hormone twice weekly for at least 8 months (supposed to stay local).
Got some more bloodwork:
progesteron 13.7 ng/ml
testosterone 29ng/dl free test 1.9pg/ml bioavail test 4.1ng/dl
dheasulfate 135 mcg/dl
Vit D 45
All of these were in normal range for postmenopausal female except progesterone, but it was an acceptable level for treatment, but I was still having symptoms.
New dosage: Sublingual dose (split am and pm)...
BIEST .75mg (70%estradiol and 30%estrogen)
TEST 0.25mg(same dose)
After 3 months, I began having more hot flashes, night sweats, insomnia, urogenital symptoms were better at first but starting coming back. PLUS....I began to lose weight, had continual headaches, hangover type feeling in am, muscle and joint aches, foggy thinking. The headaches get a little better if I eat a small snack.
Got some more bloodwork (5 mo after dosage change)...
estradiol 22 pg/ml
Progesterone 52 ng/ml********equal to 3rd trimester pregnancy
Vit D 45
I have never taken any dhea. Are my adrenals now starting to pump out hormones themselves, if so, why not more estrogen? If these are my serum levels, I can only imagine that my salivary levels are way high. What is going on? It appears that my adrenals are now making more dhea than they were baseline (dhea has increased 3X over baseline although still in the normal serum range)and this is now being converted to excess progesterone and testosterone????? Why is my estrogen still low in comparison....not making any? The pharm D has no idea and my doctor has no idea. Now the doctor wants to put me on a conventional HRT called Femhrt with synthetic estrogen/progestogen but I am scared to take it.
I have decreased the sublingual troche dosage by 1/2 on my own and feeling a little better. Since all 3 hormones are in it, I have no way to take individual dosages of estrogen or progesterone. I tried to go down to 1/4 dose, but the urogenital symptoms were really bothering me (still taking vaginal estrogen though), so went back up to 1/2 dose. I will try to wean off more slowing, but I don't know what to do next.
Any advice would be helpful!