by Sinead


I am wondering how progesterone therapy works to stop fluctuations as it exerts no actual control over estrogen levels?

I'm on perimenopause and am trying 200mg of progesterone cream as recommended, but I get clear hormonal fluctuatuons, like my mood dips down, then comes back up a few hours later. It's all very exhausting.

How can the progesterone stop these fluctuations???

Comments for Fluctuations

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Sep 06, 2022
by: Joy

Hi Sinead

Progesterone does control estrogen but only once it has become dominant. Progesterone needs to be used correctly to achieve this. You don't say how long you have been using progesterone, it can take between 2-6 months before this is achieved, longer if estrogen is high and severity of symptoms. The How to use Progesterone Cream explains in more detail. Progesterone should be used no less than twice a day, half in the morning and the other half at night.

Peri-Menopause is a challenge and can be a torrid time in a women's life. Progesterone will cause upsets but unless you have regular monthly cycles or TTC then progesterone should be used every day with NO breaks going forward. Your body needs the extra support now, progesterone levels drop sharply while estrogen remains the same.

What is your Vitamin D3 level? A deficiency reduces the benefits of progesterone, so if it is not optimal it will have an effect on progesterone. It is also connected to every single functioning cell in our bodies.

Progesterone therapy is not easy, I wish it was. Time and patience is needed.

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