Factor V

I have Factor V leiden disorder. Having thick lining and am post menopausal. Dr. put me on Prometrium 12 days of each month. Is this safe with having Factor V?

Comments for Factor V

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Nov 20, 2007
Factor V Leiden disorder
by: Wray

Hi there Yes Prometrium is safe, it's a natural progesterone. But are you taking the oral version or suppositories? 90% of oral progesterone is destroyed by the gut and liver as it passes through, so is not very effective. The cream, suppository or injection route is much more effective. I have pasted some comments from research papers for you.

"The studies reviewed suggest bioidentical progesterone does not have a negative effect on blood lipids or vasculature as do many synthetic progestins, and may carry less risk with respect to breast cancer incidence. Studies of both bioidentical estrogens and progesterone suggest a reduced risk of blood clots compared to non-bioidentical preparations. Bioidentical hormone preparations have demonstrated effectiveness in addressing menopausal symptoms."

"Progesterone inhibited cholesterol into cholesteryl ester (CE) and decreased CE cellular levels."

"Coronary hyperreactivity, a putative component of coronary artery disease mediated via increased vascular muscle thromboxane prostanoid receptors, can be prevented by subphysiological levels of P, not only in nonatherosclerotic (previously shown) but also in preatherosclerotic primates."

Hope this helps Take care Wray

Oct 10, 2010
Factor V Leiden and Progesterone
by: Lisa

Wow this is what I have and my doctor suggested I take some progesterone too! I didn't think I would find any answers.

Oct 14, 2010
Factor V Leiden and Progesterone
by: Wray

Hi Lisa Yes we have many asking about it, just another last week in fact. I'm pleased your doctor recommended progesterone. In FVL, factor V remains active, which allows over production of thrombin, leading to excess clotting. Oestrogen in any form is contraindicated as it increases the affect of thrombin, progesterone on the other hand decreases it by 10-15%, please see here. It also protects against lipid peroxidation and atherosclerosis, please see here and here. Please avoid all contraceptives as they increase the risk of clots, see here and here. The only safe contraceptive is the copper T IUD, it doesn't leak a drug into the body, see here. If you should consider using progesterone, please read this page on How to use progesterone. You might like to see the other delivery systems available, please see our page on Progesterone application methods.
Take care Wray

Jul 10, 2012
Can anyone help answer this
by: Anonymous

I have factor v liden, They did a Historctamy in 2005 that is when they found I had it, after I got 2 blood clots after surgery. They will not give me anything to take for the side effects of the historctamy. I have been taking B12 on my own to help with dryness..
I was told by friends maybe yam cream will help.
My doctors have said they have to see that others have taken yam cream or progesterone or shots before they will try. I need some back up from other doctors who have put there patients on this with factor v.. can anyone help???? I had The historctamy at 37 and Iam now 45 my marriage has suffered from this...

Jul 11, 2012
Can anyone help answer this
by: Wray

Hi there Please read the papers I gave to the two women above. You could always print them out for your doctor. The two women also said both their doctors gave them progesterone. Please have a vitamin D test done, you could be low in this, as this also prevents clotting, see here, here, here and here. For more info on vitamin D levels, test kits etc see the Vitamin D Council, GrassrootsHealth, Birmingham Hospital and Vitamin D Links websites. Blood levels should be 70-100ng/ml (175-250nmol/L) and not the 30ng/ml (75nmol/L) most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although the latest research indicates it should be 10,000iu's per day, see here. Take care Wray

Mar 25, 2014
i have as well. i use YL Progessence Plus

I use an all natural form of progesterone. I got it through young living and it is an oil. I have not had any issues and it def helps.

Aug 16, 2014
Re: Young Living Oils
by: Anonymous

I read a report from a Dr. Can Purser, MD. about the Progressive Plus from Young Living oils. It was very informative about how well it worked except when it came to Factor V, He said NEVER use topical or oral hormones. I have had a Pulmonary Embolism which was not only painful but very scary. Please be careful with these "natural" remedies as well. Please don't think I'm against the oils, I use them fro many other things. I wish that there were more specific answers for those of us with Factor V.

Apr 03, 2015
Factor 5 and Bio Identical hormones
by: Anonymous

Hello, if anyone can share information with me I would appreciate it. I am a 55 year old female and found out that I have Factor 5 - through 23 and me. Is it safe to stay on my BIO hormones?? There is not much literature out there on this subject.

Apr 06, 2015
transdermal estrogen is it safe in Leiden V carriers
by: Anonymous

Since the dose of oral estrogen is 20 times greater than the comparable dose in a patch and avoids the first bypass through the liver where most clotting factors are, isn't it much safer for a Leiden V woman.

Aug 26, 2015
Is it safe to take progesterone with factor v?
by: Anonymous

I have factor v. Is it safe to take progesterone with it? It is the 12 day prescription to regulate my periods.

Mar 21, 2016
Factor V and Pregesterone
by: Laura


I am wondering if I can take a progesterone cream (3 ounces) if I have Factor V?
I had a partial hysterectomy 9 months ago and now am experiencing hot/cold flashes and insomnia.

I understand I cannot take hormones but I have been researching and see that maybe progesterone might help? What will I see in changes to my body if I apply this cream?

Thank you for your reply.

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