Extreme high estradiol

by Komal Dubey
(Chandler, AZ, USA)

I’m 52 and started peri-menopause symptoms last year. I had missed period and then 1 month+ of very heavy period. I was recommended 200 mg progesterone tablet which I later switched to this cream - best decision ever and my periods were regular till 3 months ago. I missed one month, the second was sort of regular but lasted 8 days and then I had another one in week which lasted 45 days - so I switched to using 200mg daily instead of the 14 days (I was on 28 day cycle through out my life till last year).

I did a test recently:
estradiol is 2973 pmol/L and
progesterone is 2.0 nmol/L.

The symptoms I have are constant breast tenderness, bloating. I Do have mood swings or irritable at times but manageable relative to bloating and tenderness.

Should I increase dosage to 400mg daily or go higher?

I do take daily 5000iu vitamin D3, 5000mcg vitamin B12 supplement and 65 mg elemental supplemental iron with vitamin C. Since the last year I am still on the lowest avg iron range to be ‘out of deficient range’

Comments for Extreme high estradiol

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Jun 08, 2022
Extreme high estradiol
by: Joy

Hi Komal Dubey

Peri-Menopause can be a torrid time for most women. It's a time when the cycle becomes erratic and blood flow is heavy with clots.   The correct use of progesterone will help to ease these symptoms but bear in mind that nothing will change the natural process of the human body.  I suggest that you use the cream every day with no breaks until your cycle returns to normal if it does. You may need to use more than 200mg per day until you get over these adverse symptoms.  You will have to experiment with the amount used.  If your bleeding becomes extremely heavy with clots try the Heavy Bleeding Protocol.  Type that in the search bar.  It has helped so many women.  

I am pleased that you switched to progesterone cream as all oral progesterone is not the best Delivery Method as about 96% get destroyed by the gut and liver.  

Whilst each hormone test is important, it is the ratio between progesterone:estrogen that is important.  Yours is 0:1 it should be around 600:1 which means that you need to use more progesterone.  Increase to 400mg per day and see how you get on.  As soon as things stabilize you can reduce the amount of cream slowly.  Please read the Hormone Testing, How to use Progesterone Cream and Estrogen Dominance pages.  

Breast tenderness is a result of excess estrogen and a lack of iodine, selenium and tyrosine.  Have you had your thyroid tested and are you taking iodine to support it? Try rubbing some Natpro Progesterone Cream on your tender breasts that should ease the pain slightly as progesterone is an excellent anti-inflammatory.  

It's extremely important to take the Cofactors mentioned when take Vitamin D3.  A D3 deficiency reduces the benefits of progesterone as is connected to every single functioning cell in our bodies.  Magnesium and K2 are vital.

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