extreme fatigue follicular phase
I have a history of Graves Disease (hyperthyroidism) and in the last two years have been diagnosed with Adrenal Fatigue and Hashimoto’s Disease. I struggled with infertility for years and failed many IVF attempts, becoming pregnant the old fashioned way with the help of progesterone cream. My pregnancies were supported with IM progesterone injections throughout. And I felt my best (also lost weight) after baby #1 when the doctor allowed me to continue the Progesterone Injections a few months after delivery.
I have a history of abnormal bleeding, including spotting for 3-5 days before AND after a period. I also had an episode of endometrial hyperplasia. It is not unusual for me to ovulate at the very beginning of a cycle (sometimes while I am still bleeding).
I have long had symptoms intermittent debilitating fatigue and brain fog. My motivation drops to zero. I have low energy, may nap once or twice a day and still feel tired. My creativity disappears and I have trouble finding words, have no interest in social contact and difficulty communicating. I have great difficulty losing weight and must go to ridiculous lengths to avoid gaining weight. I often have a migraine before my period begins. I have intermittent extreme thirst and often My breasts get sensitive and enlarged. My libido and sexual response is low. I feel most interested in sex just at the time my period is ready to begin rather than mid-cycle.
I have very low serotonin and many indications (from an OATS urine analysis) of poor Krebs cycle / mitochondrial function. I also have compound hetero mutation on the mthfr gene. I have been taking many supplements to assist with these issues. This includes:
Vitamins C, D, B, M-B12, iron
Naturally dessicated thyroid
Adrenal cortex supplement, Mitochondrial energy optimizer, broad spectrum amino acids, DHEA, Testosterone, 80 mg Progesterone (luteal phase only), Sam-e, Omega 3, 5-Htp, Magnesium, Chromium, Zinc, Selenium, Lithium, Hcl, and digestive enzymes.
Most recently the doctor dropped my DHEA from 25 mg to 10 mg b/c of a high blood test. At the same time he added the progesterone and testosterone. My libido has declined since this change. (my hunch is to blame the lower dose DHEA, tho it is a shock that the progesterone & testosterone wouldn’t help!)
Since beginning the supplementations I am markedly improved and my good days are better than ever. Also, a pattern has become evident that really points at progesterone – that I start to improve a few days into midcycle (after starting progesterone) and then feel my best as my period draws near.
My periods of tiredness return as soon as spotting begins and progressively worsen. My tired feelings are somewhat unpredictable. Some days I may be tired all day, but perk up at night. Some days I feel horrible upon waking, then improve for two hours, then need a nap at lunch time. Other days I feel fine all morning then feel exhausted and flat for several hours in the afternoon. Other days I take a nap both morning and afternoon. I spend about half of the month with days of some degree of poor function and exhaustion and half the days feeling mostly well. The more I am closer to well, the less patient I am with my bad days, and am really at my wit’s end, ready to reclaim my life and feel well EVERY day!
Two months ago I went from taking no progesterone to taking 80 mg during the luteal phase (which I have a very difficult time finding enough places on my body to smear it), along with the testosterone. I’m wondering whether my body is not appropriately absorbing it and have also been researching about pregnenolone – thinking this precursor hormone may be a good option. I think back to when I felt well taking the progesterone as an injection, but my doctor now won’t consider that.
I am desperate to get better and look forward to your advice.
With many thanks in advance, from a woman suffering in Singapore.