Doesn't Progesterone make fibroids grow?

by Margaret

I have read that both oestrogen and progesterone make fibroids grow, so I am a little concerned that I'm actually making things worse by using progesterone cream.

I was diagnosed with a fibroid in January. I have been using 200 mg each day (split does morning and evening) only for a few weeks, I was using less previously.

It's costing a lot of money using it at this level. Plus it takes a lot of effort to get 100 mg to absorb each time. I will persevere.

I'm in the UK, so the NHS do not prescribe bio-identical hormones, only synthetic ones.

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May 16, 2017
Doesn't Progesterone make fibroids grow?
by: Joy

Hi Margaret

You would be correct in saying that estrogen helps fibroids to grow, but certainly not progesterone. Please can you advise where you read this, many thanks.

Estrogen is a mitogen, causing cells to proliferate. Progesterone inhibits mitosis, but enough has to be used. If too low it will continue to stimulate estrogen. This is something so few doctors understand, and so they blame progesterone. A study on tumour growth found exactly this, too little caused the tumour to grow, see here.

Fibroids are caused by oxidative stress, you need to address the inflammation that is causing them. Removing them by surgery will still leave you with the oxidative stress, it's essential to take large amounts of antioxidants to reduce the Inflammation. One of the most powerful antioxidants is vitamin D3. It appears a low level causes fibroids to grow, taking it certainly reduces them, see here.

Please have a test done. Too little progesterone makes matters worse for so many people, this website is littered with complaints from women. Too little vitamin D3 will also make matters worse, as a low level reduces the benefits of progesterone.

It can take a long time for the smaller fibroids to be absorbed back into the body, larger, problematic ones often require surgery. Time and patience is needed.

Please read these pages and all the references. Hope this helps.

Estrogen Dominance

How to use Progesterone Cream


Vitamin D3


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