Does progesterone help reduce the size of large fibroids >10cm ?
My wife has endometriosis and large fibroids. She had endometriosis excision in 2014 and no longer suffers from endometriosis pain.
She takes a number of natural products, among them being bioidentical progesterone she started in 2014. She has tried creams and troches.
The first cream was prescribed and compounded and used natural progesterone. She used it externally for about a year but it didn't help much. She tried other natural progesterone creams / gels including Karuna pure progesterone cream and Progest-E from Dr Lee but nothing seemed to bring noticeable improvements.
The most benefit came once she started using bioidentical hormone troches which she started May 2016. The troches absorb transbuccally and avoid the liver. The initial prescription was 50mg progesterone/1mg testosterone twice a day. For the past year or so she has been on 62.5mg progesterone/0.75mg testosterone twice a day.
We have seen some research that seems to indicate that progesterone may be more effective for smaller fibroids but for larger ones >10cm they cause them to grow. Apparently the fibroids have progesterone receptors which are stimulated by progesterone supplementation? It's hard to find enough conclusive research on this.
In May 2014 my wife's ultrasound identified two fibroids of 4cm and 3cm respectively. From May 2014 to July 2020 the fibroids grew to 12cm and 7cm respectively while supplementing with progesterone. She hasn't done any further tests since July 2020 but she still looks 3-4 months pregnant.
We have just stopped her progesterone troche tonight until we can conclusively rule out whether or not the progesterone is causing the fibroids to grow.
We have been doing intermittent fasting for over a year and have just started keto this past month.
My wife currently takes EGCG @ 800mg / day, D3, zinc, B12, iron. Up until a few months back she was regularly taking selenium, vitamin E, folate, vitamin A, a range of methylated vitamin Bs, vitamin C, cod liver oil, magnesium, red raspberry leaf and ladies mantle. Over many years she has taken serrapeptidase and myomin for periods of time and also taken MSM and NAC at various times.
She avoids xenoestrogens and we try to eat organic / spray free and free range.
Appreciate your feedback on the use of progesterone for fibroids of this size.