Does progesterone help reduce the size of large fibroids >10cm ?

by Ben
(Queensland Australia)

My wife has endometriosis and large fibroids. She had endometriosis excision in 2014 and no longer suffers from endometriosis pain.

She takes a number of natural products, among them being bioidentical progesterone she started in 2014. She has tried creams and troches.

The first cream was prescribed and compounded and used natural progesterone. She used it externally for about a year but it didn't help much. She tried other natural progesterone creams / gels including Karuna pure progesterone cream and Progest-E from Dr Lee but nothing seemed to bring noticeable improvements.

The most benefit came once she started using bioidentical hormone troches which she started May 2016. The troches absorb transbuccally and avoid the liver. The initial prescription was 50mg progesterone/1mg testosterone twice a day. For the past year or so she has been on 62.5mg progesterone/0.75mg testosterone twice a day.

We have seen some research that seems to indicate that progesterone may be more effective for smaller fibroids but for larger ones >10cm they cause them to grow. Apparently the fibroids have progesterone receptors which are stimulated by progesterone supplementation? It's hard to find enough conclusive research on this.

In May 2014 my wife's ultrasound identified two fibroids of 4cm and 3cm respectively. From May 2014 to July 2020 the fibroids grew to 12cm and 7cm respectively while supplementing with progesterone. She hasn't done any further tests since July 2020 but she still looks 3-4 months pregnant.

We have just stopped her progesterone troche tonight until we can conclusively rule out whether or not the progesterone is causing the fibroids to grow.

We have been doing intermittent fasting for over a year and have just started keto this past month.

My wife currently takes EGCG @ 800mg / day, D3, zinc, B12, iron. Up until a few months back she was regularly taking selenium, vitamin E, folate, vitamin A, a range of methylated vitamin Bs, vitamin C, cod liver oil, magnesium, red raspberry leaf and ladies mantle. Over many years she has taken serrapeptidase and myomin for periods of time and also taken MSM and NAC at various times.

She avoids xenoestrogens and we try to eat organic / spray free and free range.

Appreciate your feedback on the use of progesterone for fibroids of this size.

Thank you.



Comments for Does progesterone help reduce the size of large fibroids >10cm ?

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Feb 21, 2022
Does progesterone help reduce the size of large fibroids >10cm ?
by: Joy

Hi Ben

Endometriosis and Fibroids are both caused by oxidative stress and unless the Inflammation is dealt with, your wife will always experience problems  Even if surgeries are done, they both come back in other areas in the body.  Progesterone will help the body absorb smaller fibroids, larger ones require surgery unfortunately.  Progesterone will not cause fibroids to grow, it helps if used correctly.

It is so important to use a good natural progesterone cream such as Natpro which is a 3.33% cream.  If used correctly it helps a multitude of our modern day ailments.  This applies to men as well.  Please read How to use Progesterone Cream.  She needs to use between 100-200mg per day, more if symptoms are severe  Use half the amount in the morning and the other half at night in order to keep levels stable.

Torches/Lozenges are not very effective as 50% of the progesterone is destroyed by the gut and liver which means that not much progesterone is being absorbed into the body.  Delivery Methods explain in more detail.

I do not believe that any woman needs to take extra estrogen.  There are well over 100 estrogen mimics in our Environment as it it, why take more?  Testosterone has a dark side and I don't recommend that either, see here, here and here. Not to mention oily skin and facial hair.  

I have not used EGCG, I prefer and recommend fermented veg, kefir milk/water, turmeric etc for inflammation.  The gut is very important if it is unhealthy it causes all sorts of health issues including inflammation.  I am concerned about vitamin A.  Not only is she taking it but she is also taking cod liver oil which has a high content, it can become toxic. But I am also confused, why take CLO when she is already taking D3 and vit A?  NAC is an excellent antioxidant.  

Please read the Vitamin D3 page, it explains how to use it and what to avoid.

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