Difference between Natpro and Prescription Progesterone?

by Kimberly
(Cincinnati, Ohio)

After trying to conceive for 2 years, we've finally gotten pregnant and already have a couple tubes of the Natpro but the doctor wants me to use a more concentrated gel that's inserted intra-vaginally. I'm told that Natpro is simply not concentrated enough and I need something stronger, is this true? What has been your experience with women who would like to use a more natural cream instead of a prescription?


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Jan 20, 2012
Difference between Natpro and Prescription Progesterone?
by: Wray

Hi Kimberley I'm delighted to hear you are pregnant. Strange, concentration is a factor, but it's the actual amount of progesterone used which is critical! Undoubtedly you'll be given Crinone. It comes with an applicator for the vagina, and there are two strengths 4% and 8%. Each applicator delivers 1.125 grams of Crinone gel containing either 45 mg (4% gel) or 90 mg (8% gel) of progesterone in a bio-adhesive base containing glycerin, mineral oil, polycarbophil, carbomer 934P, hydrogenated palm oil glyceride, sorbic acid, sodium hydroxide and purified water. It's usually given once a day, whereas I recommend using progesterone twice a day, to prevent levels dropping too fast. I would also recommend using a minimum of 200mg/day to ensure enough progesterone is used. Natpro is a 3.3% cream, so it's not as strong, but the advantage is it can be applied anywhere. I always recommend using it in the vagina too when pregnant. There are a plentiful supply of blood vessels which carry the progesterone to the uterus where it's needed. I have helped many women who've had previous miscarriages or pre-term births, who've only used Natpro. All delivered successfully. We do have more info on our Pregnancy page. If you are already pregnant, please be aware that using progesterone in any form can cause Oestrogen Dominance to occur in the early days of use. You'll notice on the Crinone site that the side effects of using it are all oestrogen dominance ones. It's for this reason I prefer it if women begin using progesterone before falling pregnant, to prevent this occurring while pregnant. The symptoms are the same as one gets when first pregnant. If it should occur please don't reduce the amount, but increase it. This gets rid of the symptoms quickly. I hope this helps you make a decision. Take care Wray

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