Daily dosage-2 or 4 times per day
I am a 46 year old male. I have a question re. daily regimen to apply progesterone transdermally. I have tried to apply it on 2 separate occasions at 50 mg in AM and bedtime (100 mg in total), as well as 4 times per day at 50 mg with at each meal time and bedtime (200 mg in total). Both times I have experienced clear weight gain over short period of time (a week). I now realize that weight gain is due to estrogen dominance. I have read that some recommend taking it in AM and bedtime, while others prefer to take it 3-4 times per day.
Could you clarify what the best way to take it? Is twice per day a preferable option? Should I start with higher amounts (at least 100 mg in AM) as well as 100 mg at bedtime? Is it possible that starting with higher amount in Am would prevent estrogen dominance, and therefore, not lead to weight gain? I had no other side effects on progesterone creme except weight gain but it was quite rapid which prompted me to stop it.
Just for completeness, I would like to mention that I take 20 mg of Cortef in split dosages for adrenal fatigue as well as thyroid hormone for hypothyroidism which is not optimized at the moment. I have insulin resistance, sleep issues and have gained 40 lb over last 4 years.
Thank you very much for your responses.