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Crinone Suppositories vs. Natpro?

by Maureen
(Port Washington, NY)

Hi Wray. I was diagnosed with PCOS 20+ years ago and had all the classic symptoms, irregular periods, acne, facial hair, etc. I never suffered from obesity though.

I thought I was infertile since I have not been on birth control my whole marriage (7+ years) and never got pregnant, but just this past March we surprisingly got pregnant and we weren't even trying. It ended up being a blighted ovum and I had a d&c. Then I ended up pregnant again this past July and it went to 10 weeks and then they couldn't find a heart beat. Everything looked great, but my progesterone levels dropped a bit so they put me on Crinone suppositories to help.

My question is... will Natpro work as effectively as the prescription Crinone? There are side effects to the fetus if used in early pregnancy and I don't like taking that risk if I end up pregnant again and need progesterone supplements. I don't think progesterone deficiency was the reason for the missed miscarriage this past time. I have a feeling it might be that I am insulin resistant and I have been put on Metformin to help with that. Does Natpro help with insulin resistance as well?

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Oct 08, 2010
 Crinone Suppositories vs. Natpro?
by: Wray

Hi Maureen I don't know why they put that info on the Crinone site about possible side effects, they are none! But there are huge risks if a progestin is used in early pregnancy. The progesterone used in all the suppositories and injections preferred by doctors, is progesterone. It is not a progestin. To answer your question, yes the Natpro does work effectively, I've recently helped two more women who used it the entire pregnancy, and have since sent me photos of their sons. I've used suppositories before I found a cream, and must confess to far preferring it. It can be used anywhere and if the amount needs to be adjusted, it's so easy to do so. PCOS and insulin resistance which is implicated in it, can both contribute to ovarian malfunciton. Metformin does not cure the problem, it merely reduces blood glucose levels. Glucose is the most oxidising substance we make, this in turn causes free radicals to damage the ovaries. For more info please see our page on PCOS. If you do suspect IR, it is possible to reverse this naturally, please see our page on Insulin Resistance. A lack of vitamin D can cause PCOS and IR, it also reduces the benefits of progesterone, please see the Vitamin D council website.

Progesterone does help stabilise blood glucose slightly, whereas oestrogen exacerbates it. As it's almost always low in PCOS it is an essential part of the protocol. As progesterone can cause oestrogen dominance when first using it, I always suggest starting well before pregnancy so this doesn't occur while pregnant. For more info please see our page on Oestrogen Dominance. Finally we do have a page on Pregnancy too, please have a read through it. Take care Wray

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