Can progesterone cream help me if I have Premature Ovarian Failure (POF)?

Hi Wray -

I've been diagnosed with POF - how likely is it that progesterone cream will induce a period? I would like to try and get pregnant naturally, but with my diagnosis and age, I'm not feeling very hopeful.

At age 39, I went off birth control pills after 18 years. I assumed my body was adjusting when my periods became irregular. However, after going 4 months without a period, I went to an endocrinologist who ran lab tests and received the following "post-menopausal" results:

FSH: 169
Estradiol = 32
AMH = < 0.03 (undetectable)

I was put on Provera for 10 days to induce a period which never came. 2 weeks later, I had an ultrasound done where 4 follicles at 8mm were found (2 on each side). The endocrinologist was surprised and told me I should expect a period soon.

My period did not come that month, so I began Chinese herbs and acupuncture. 2 months later, I finally got my period (after 200 days) and exactly 28 days later, I got another. I thought I was cured, but 8 months have passed again and no sign of a period.

Since then, I've been taking many supplements in addition to my herbs: multi-vitamin, CoQ10, ProOmega-D, Evening Primrose, Symplex F, Ovex and DHEA (25mg).

I also went to a compounding pharmacy to have saliva testing done. Results showed I was low in progesterone and DHEA. That's when I was prescribed natural progesterone cream to try and kickstart a period - however, it's been 2 months now with no luck.

I should mention that POF does not run in my family - my mom went through menopause at 55 and my sister is getting her period regularly at 47. I also tested negative for multiple antibodies tests, Fragile X, Turner's Syndrome, etc. I have no cysts,, no fibroids and my uterus is apparently very healthy.

Aside from amenorrhea and terrible numbers, I have no POF or menopausal symptoms - i.e. no hot flashes, no night sweats, no vaginal dryness, no brain fog, no insomnia. I eat mostly all organic food, exercise regularly and am not overly stressed.

Your thoughts and advice would be greatly appreciated. Thank you -

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