15 year old grand daughter

by Kay
(Ventura, CA)

Hi Wray,
I have written prior regarding my own post menopausal problems with a thickened uterine lining and polyps but this one is for my grand daughter. She is now 15 but has had problems with nausea and vomiting since puberty. She has nausea in the mornings and it is much worse before and after her period with vomiting. Most days she gets better by late morning but during her cycle is sometimes sick all day. She does have cramping but the nausea seems to be there with or without it.

She recently had blood testing for hormone levels, thyroid, being anemic, celiac disease and more. Everything came back normal. Do you think the progesterone or estrogen levels could be the cause as it is worse before, during, and just after her cycle.

Thanks Wray


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Dec 14, 2012
15 year old grand daughter
by: Wray

Hi Kay The timing is perfect for a hormonally related problem. And 'normal', oh dear I get so frustrated! They look at a range for the hormones, and if it falls within this everything is normal. Very rarely do they look at the ratio, and this is what it's all about. Both progesterone and oestrogen could be within range, but if oestrogen is high 'normal' and progesterone low, all hell can break loose. The nausea is so simple to explain. It's caused by something called substance P, oestrogen tends to ramp it up too, see here, here, here here, here, here here and here. Substance P does suppress progesterone, but if enough is used progesterone suppresses substance P. Oestrogen destabilises blood glucose, progesterone stabilises it, see here. It would appear your granddaughter is not ovulating each month, so her testosterone and oestrogen have nothing to counter it. This is often the case in puberty. We have more info on our Menstruation page. An unstable blood glucose and/or a sharp drop in it, will cause nausea, so the whole ties together nicely. Particularly as it's worse when oestrogen is highest, i.e. prior to bleeding and during her period. I suggest she tries using 100mg/day progesterone, rubbing some over her tummy each time she does, using the rest over other areas. She must avoid all sweet foods at night, by sweet I mean all sugars, and even those found in all grains, legumes, processed milk and sweet starchy fruits and vegetables. Her blood glucose is dropping too low over night, hence the nausea in the morning. I also suggest she takes 4000mg glutamine at night. This is remarkable at stopping nausea. The brain can use it in place of glucose, so it stabilises the blood glucose. Plus it's the only substance the enterocytes lining the gut can use for energy, healing and repair. Please let me know if this helps her. Take care Wray

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