Questions about DIM

by Shari

Hi, Wray. I started taking DIM about a week ago to help with my estrogen dominance because progesterone wasn't quite enough even though I use about 800mg - cycling. I can't afford to buy more. I am having terrible water retention with the DIM. I have read that this is normal for a time, and then I will start to feel better. Do you know how long it takes to feel better with the DIM? It is really hard feeling this way. Thank you.

Comments for Questions about DIM

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Feb 10, 2012
Questions about DIM
by: Wray

Hi Shari Most people are lead to believe DIM reduces oestrogen levels, it doesn't. It changes the ratio of bad oestrone to better. Oestrogen is broken down into 2 principle metabolites, 2-hydroxyestrone (2-OHE1) and 16-alpha hydroxyestrone (16alpha-OHE1). 16alpha-OHE1 is regarded as a potent oestrogen, whereas 2-OHE1 is a weak oestrogen. DIM increases levels of 2-OHE1, by doing so it also increases the ratio of 2-OHE1:16alpha-OHE1. This increased ratio is associated with a lower risk for breast cancer, see here. Other studies have found a protective role too. You could try taking Calcium D-glucarate, this does reduce oestrogen. Oestrogen is metabolised in the liver by glucuronic acid, the process is known as glucuronidation. Glucuronidation is one of the major detoxification pathways of the liver. It removes carcinogens, toxins, tumour promoters, the sex hormones ie, the androgens and oestrogens, mineralocorticoids and glucocorticoids, aromatic and heterocyclic amines, polycyclic aromatic hydrocarbons, various nitrosamines, drugs, fungi etc. It's then excreted in the bile, but an enzyme in the intestine called beta-glucuronidase reverses the glucuronidation process. It breaks the glucoronide bond between a toxin and glucuronic acid, and releases carcinogens, toxins and excess steroid hormones back into circulation. There's evidence beta-glucuronidase activity is increased in breast and prostate cancer. Calcium D-glucarate inhibits beta-glucuronidase, see here, here, here and here. Incidentally this enzyme is produced by undesirable gut bacteria, supplementing with probiotics suppresses the bacteria, and subsequently the beta-glucuronidase. Unfortunately I can't tell you when the water retention will go down. Every time you stop the progesterone it allows oestrogen to rise again. Have you considered using it daily for 2-3 months, but a lesser amount. Daily use will ensure progesterone becomes dominant, and oestrogen can't rise. Please consider this. Take care Wray

Feb 10, 2012
Questions about dim
by: Anonymous

Hi Shari I used dim before for quite a while had the same reaction. I think you have to be careful with this. It works for some but when I used it I felt horrible even women who work in the health store I talk to said the same thing if you look at slot of the labels you will see it contains soy. Maybe that the problem or the fact that from recent research I found that not only does it change estrogen to more favorable ones but it also helps your body make good estrogen. Good or bad who wants to make more estrogen? Anyway it's good in some ways but not everybody tolerates it different body chemistys. I think calcium d glucarate is abetted option for getting rid of estrogen hope this helps

Feb 11, 2012
Questions about dim
by: Wray

Hi there Thanks for your input, as I've not heard of this problem before Shari mentioned it. Take care Wray

Feb 11, 2012
DIM and Taurine
by: Shari

Thank you so much for all of the comments. You had also mentioned taurine before. I would like to know more about it. Is it in a food source, or do we need to supplement it. How would I know if I don't have enough? Thank you so much.

Feb 13, 2012
DIM and Taurine
by: Wray

Hi Shari You can read a short blurb about taurine here. Scroll down till you get to the info. It's an amino acid, a potent antioxidant, and is found in all tissues subjected to high oxidative stress, the heart, eyes and liver. It's not found in any vegetable, fruit, nuts or seeds, only animal protein. It's essential for bile production, insufficient bile allows toxins to back up in the body. There's no way of knowing if you have enough, unless you have a blood test. And I'm not sure if they even do one! If you don't eat much meat or fish, this has the highest level, then you could well be low. It's a very calming amino acid, acting as a neurotransmitter in the brain to calm that down. It also calms the heart if it's beating erratically or too fast. Good if you've drunk too much coffee! These are a few papers, see here and here. And more here, here, here, here, here, here, here, here, here and here. Take care Wray

Mar 10, 2012
Does DIM causes you to be late for you period?
by: Anonymous

I just recently started DIM in mid February and now i'm 2 weeks late for my period. I took a pregnancy test and it showed boarderline HcG levels so I got a blood test done and it showed negative. I have every symptom that i'm going to start my period and still have not. Any insight on this?

Mar 11, 2012
Does DIM causes you to be late for you period?
by: Wray

Hi there I've not heard of DIM causing the cycle to be upset. But as it does change the ratio of the two oestrone metabolites, it could affect it. Take care Wray

May 04, 2012
I believe DIM isn't all positive!
by: Anonymous

Hi there

I have been taking DIM now for approx. 5 months and I started taking it because my skin was breaking out. My skin is better, although this month I have had a little break out on my chin. I have also noticed in the last month or so that my hair is falling out heaps, and the only thing I can put it down to is DIM, so am going to stop taking it and hopefully my skin will be ok, time will tell. Another thing I have experienced is that my breasts are quite sore after ovulation. A friend put me on to DIM as she said it helped her a lot with her moods. It may be good for some, but I believe it is making my hair fall out considerably. Has anyone else experienced this. I wonder if I am mucking my hormones up, and doing damage to my liver? Thanks

Feb 26, 2013
DIM my PMS is better but Im losing my hair!
by: Anonymous

I was so excited to find a DIM supplement Estrobalance BUT i have now found my hair falling out in heaps! I know it is the DIM because i stopped taking it for about 5 days and within a week my hair shedding dropped to a fraction of what it has been!


Mar 03, 2013
DIM my PMS is better but Im losing my hair!
by: Wray

Hi there We do have a page on Hair Loss you could look through. It has a list of nutrients which help hair growth. You could consider using progesterone too, as that stops PMS, see here. It also helps hair growth too. There's more info on our page How to use progesterone cream. Take care Wray

May 20, 2013
Can DIM be used together with progesterone cream?
by: Bubbly

Hi Wray.

Used Nature's Way DIM for 1 mth and found that it really helped with curbing hot flashes, migraines and mood swings. However, it did not regulate my erratic cycles and excessive perimenopausal bleeding. So I started using it with progesterone cream. A quarter tsp of progest cream day and night, from day 14th to 28th helped to stop the bleeding. Now third mth into using the cream, my cycle was stretched to more than 30 days and longer. Although I am relieved that I am no longer battling 2 periods a mth or incessant spotting between periods, I am concerned about the "delay". Is this normal? Currently only using DIM 3 days before and during menses.

May 24, 2013
Can DIM be used together with progesterone cream?
by: Wray

Hi Bubbly I'm pleased the DIM helped you, it's helped many women. Although it won't regulate your period or help the excessive bleeding. I'm surprised the progesterone helped though, as you are using so little, I've normally found 400mg/day is needed, plus a few nutrients too. It can upset the cycle when first using it, making it earlier or later than normal, it's nothing to worry about, it usually settles in time. We do have more info on our Peri-menopause page. Take care Wray

Jul 31, 2013
DIM should be used for short intervals of time
by: Anonymous

I have been taking DIM now for a few weeks to help get rid of ovarian cysts and have noticed an ENORMOUS difference in my pain level, however as I understand it from the websites and research I have done it is to be used periodically as a kind of xenohormone detox if you will and other herbs are to be used after a 4 month regimen of DIM to help maintain healthy hormone function. Maybe some of you that are having side effects after several months of use should try a different herbal regimen now that you have detoxed your system and just continue to avoid xenoestrogen in your meats, shampoos, body washes and drinking from plastics. Hope this is helpful!

Jul 21, 2014
teenage daughter
by: maria

My daughter is 13 and has been getting 2 periods a month since her period started. That's 8 months now. I started her on progesterone cream 1 1/2 months ago. The first time, cycle was lengthed from 21 days to 27. The next period, went down to 23 days, and third period using cream, cycle back to 21 days. For this last cycle, I increased the amount of progesterone . We are not using alot as I wanted to start her off slow. According to the bottle, there are 20 mg in 1/4 teaspoon. We started with two 1/4 teaspoons a day, which means she was only getting 40 mg of progesterone per day. The first month that helped in alot. Had longer cycle. But this last time, I started the cream sooner based on your chart and used more, 80-100 mg per day and her cycle was shorter. I have noticed that her periods are lighter since progesterone cream. Do you think we went backwards again because I increased the amount of progesterone and started it sooner? How do you think we should proceed? I was thinking of adding DIM. I have also started giving her vitamin D. Thanks.

Aug 12, 2014
by: Mindfulstate

I had a stroke in '09 from taking bc pills. I was 49 yrs old. I had no paralyses but couldn't speak or write. At this point you would never know I had a strokeā€¦.Blessed! Stopped the pills and went into perimenopause. That lasted 1 1/2 yrs then total menopause. Started bio-identical hormones however, no doctor was on board with giving me bio-identical estrogen due to the stroke. I did end up on the lowest dosage of Viveldot .0375 and 100 mg of progesterone. I just started taking DIM Plus over a week ago, 1 pill a day, the recommended is 2 a day. A friend told me about it and after doing my research I thought it would be safe. Any thoughts?

Sep 02, 2014
re: Mindfulstate - stroke
by: Cinegurl

Hi Mindful - Similar story here. Stroke 12/02 (that was a merry christmas!) couldn't speak, etc at first, but you wouldn't know it now. I know the differences, tho'. Now 10 cm fibroid pressing against my spine. It's been so long I guess the dr thought recommending a full total abdominal hyster + HRT would be okay. I said, "Hell no!" especially do to the fact my mother got breast cancer that tested estrogen-positive-receptive. Still, my would-be surgeon snapped back, "I'll give you the good drugs..."

HENCE...I searched high and low and in addition to switching to a 99% Organic diet (already was 80%) and started eating bales of kale, broccoli, & cauliflower, etc, (so much that if they were to cut me open I'm sure they'd see some greens sprouting in there) and I started DIM about two weeks ago. 200mg + Vitex, 2x a day.

So, here it is, my period should start any time now. I feel "fine" except for a headache (and lack of sleep thanks to the fibroid).

I will say that this month, since making the above changes, has helped reduce the pressure of the fibroid off my spine (though it still hits my sciatica a little).

As for the stroke, a few months ago my PCP FINALLY took me off coumadin and put me on Xarelto. I was already experiencing inflammation in my hands (tested c-protein receptor above normal) and I'm pretty sure now that all the inflammation I've had has been a direct result of the fibroid. But after switch to Xarelto the back pain really kicked in, 6 - 8 weeks ago. There's no way to tell if the Xarelto has had anything to do with this whole cycle of things - other than if I take myself off of it and see what being off coumadin & its side-effects is GREAT!

I've been looking to see if I should abstain from DIM during my period, or not. I decided to continue taking it to see how or if it impacts my period.

Normally, my periods are like clockwork, albeit every odd month is different than every even month. Every odd month is the "same" and every even month is its own "same".

I believe my headache right now is due to the hormonal change as my period gets ready to begin. This is (sadly) "normal". :::sigh:::

Other protocols in my regimen are 50mg Iodoral + B complex + 3000 Vitamin C + Alaskan Fish Oil + CoQ10 + Cinnamon + Milk Thistle + 5,000 IU Vitamin D (new this week).

Hope that helps! You know your body best. Listen to it.

Feb 15, 2015
Dim acne and hair loss
by: Alex

i took Dim Cause i red it help to get rid of hormonal acne ( chin acne). i took for 3 month dim. and now started to notice a hair loss. i will stop take it. and hope my hair will get back. could someone advise how to take dim safely? will start to take msm. hope it will help hair and skin. fingers crossed.

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